NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Ann Arbor, United States. In Immunity, 2015
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses.
Macrophages polarization is mediated by the combination of PRR ligands and distinct inflammatory cytokines.
Wuhan, China. In Int J Clin Exp Pathol, 2014
In the present study, we investigated the interplay of nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (NOD1, NOD2) and TLRs (TLR1, 2, 3, 4, 5, 6, 7, 8) in terms of macrophage activation, the expression and production of cytokines.
NOD proteins: regulators of inflammation in health and disease.
Toronto, Canada. In Nat Rev Immunol, 2014
Through peptidoglycan recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 enable detection of intracellular bacteria and promote their clearance through initiation of a pro-inflammatory transcriptional programme and other host defence pathways, including autophagy.