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proteins. Page last changed on 19 Dec 2016.
Nucleotide-binding oligomerization domain containing 1
Nod1, CARD4
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009] (from
NCBI)
Top mentioned proteins:
NOD2, NOD, TLR4, TLR2, V1a
Papers using
Nod1
antibodies
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.
Supplier
In PLoS ONE, 2004
... outer membrane proteins (OMPs, rabbit polyclonal, Biomeda, Forster City, CA) and NOD1 (rabbit polyclonal, Abnova, Taipei City, Taiwan), followed ...
Papers on
Nod1
Beyond the Inflammasome: Regulatory NLR Modulation of the Host Immune Response Following Virus Exposure.
Review
New
Moldova. In J Gen Virol, Feb 2016
Regulatory NLRs that augment pro-inflammatory pathways include NOD1 and NOD2, which have been shown to form a multi-protein complex termed the NODosome that significantly modulates interferon and NF-κB signaling following viral infection.
Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses.
New
Kyoto, Japan. In Cancer Res, Feb 2016
Given a role for the bacterial pattern recognition molecule NOD1 in the innate immune response to bacterial infection, we investigated mechanisms used by NOD1 to regulate H. pylori infection and its propensity towards the development of IM.
Novel epidermal growth factor receptor pathway mediates release of human β-defensin 3 from Helicobacter pylori-infected gastric epithelial cells.
New
Toyama, Japan. In Pathog Dis, Feb 2016
However, NOD1 knockdown in gastric epithelial cells did not inhibit hBD3 induction.
Lactobacillus rhamnosus GR-1 Ameliorates Escherichia coli-Induced Inflammation and Cell Damage via Attenuation of ASC-Independent NLRP3 Inflammasome Activation.
New
Beijing, China. In Appl Environ Microbiol, Jan 2016
Increased TLR4, NOD1, and NOD2 mRNA expression was observed following E. coli challenge, but this increase was attenuated by L. rhamnosus GR-1 pretreatment.
Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae.
New
Seoul, South Korea. In Immune Netw, Dec 2015
The mRNA expression of NOD1, NOD2, caspase-1 and ASC was increased in mouse footpads.
Sertoli cells have a functional NALP3 inflammasome that can modulate autophagy and cytokine production.
New
Sofia, Bulgaria. In Sci Rep, Dec 2015
Limited data exist on NOD1 and NOD2 expression in human and mouse Sertoli cells.
The intracellular location, mechanisms and outcomes of NOD1 signaling.
Review
New
Australia. In Cytokine, Aug 2015
The intracellular PRRs nucleotide-binding oligomerization domain protein 1 (NOD1) and NOD2 will be the focus of this review.
X-linked inhibitor of apoptosis protein deficiency: more than an X-linked lymphoproliferative syndrome.
Review
New
Paris, France. In J Clin Immunol, May 2015
XIAP is required for signaling through the Nod-like receptors NOD1 and 2, which are intracellular sensors of bacterial infection.
An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.
New
Impact
Cadiz, Spain. In Nat Nanotechnol, Apr 2015
In wild-type mice, intestinal immune cells containing these naturally formed nanoparticles expressed the immune tolerance-associated molecule 'programmed death-ligand 1', whereas in NOD1/2 double knockout mice, which cannot recognize peptidoglycan, programmed death-ligand 1 was undetected.
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Review
Impact
Ann Arbor, United States. In Immunity, 2015
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses.
Macrophages polarization is mediated by the combination of PRR ligands and distinct inflammatory cytokines.
Wuhan, China. In Int J Clin Exp Pathol, 2014
In the present study, we investigated the interplay of nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (NOD1, NOD2) and TLRs (TLR1, 2, 3, 4, 5, 6, 7, 8) in terms of macrophage activation, the expression and production of cytokines.
Insights into the molecular basis of the NOD2 signalling pathway.
Review
Cambridge, United Kingdom. In Open Biol, 2014
Further, where information exists, such as in relation to the role of RIP2, we have drawn comparison with the closely related, but functionally discrete, pattern recognition receptor NOD1.
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.
Impact
San Francisco, United States. In Nature, 2014
Internalized pathogens also activate sensors in the cytosol such as NOD1 and NOD2 (ref.
NOD proteins: regulators of inflammation in health and disease.
Review
Impact
Toronto, Canada. In Nat Rev Immunol, 2014
Through peptidoglycan recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 enable detection of intracellular bacteria and promote their clearance through initiation of a pro-inflammatory transcriptional programme and other host defence pathways, including autophagy.
Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.
Impact
Davis, United States. In Nature, 2013
Here we show that NOD1 senses cytosolic microbial products by monitoring the activation state of small Rho GTPases.
Activation of Nod1 and Nod2 induces innate immune responses of prostate epithelial cells.
GeneRIF
Taejŏn, South Korea. In Prostate, 2012
Nod1 and Nod2 play important roles in the innate immune response of prostate epithelial cells and the development and progression of prostate cancer.
Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.
Impact
GeneRIF
Kyoto, Japan. In Immunity, 2012
Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.
Association of NOD1 and NOD2 genes polymorphisms with Helicobacter pylori related gastric cancer in a Chinese population.
GeneRIF
Beijing, China. In World J Gastroenterol, 2012
Genetic polymorphisms in NOD1 and NOD2 may interact with H. pylori infection and may play important roles in promoting the development of gastric cancer in the Chinese population.
NOD1 and NOD2 stimulation triggers innate immune responses of human periodontal ligament cells.
GeneRIF
Kwangju, South Korea. In Int J Mol Med, 2012
NOD1 and NOD2 are functionally expressed in human periodontal ligament cells and can trigger innate immune responses.
Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in mice.
GeneRIF
Belo Horizonte, Brazil. In Clin Dev Immunol, 2011
NOD1, NOD2 and Rip2 are dispensable for the control of B. abortus during in vivo infection.
