DAMPs, ageing, and cancer: The 'DAMP Hypothesis'.
Changsha, China. In Ageing Res Rev, Nov 2015
They can act as inducers, sensors, and mediators of stress through individual plasma membrane receptors, intracellular recognition receptors (e.g., advanced glycosylation end product-specific receptors, AIM2-like receptors, RIG-I-like receptors, and NOD1-like receptors, and toll-like receptors), or following endocytic uptake.
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Ann Arbor, United States. In Immunity, 2015
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses.
NOD proteins: regulators of inflammation in health and disease.
Toronto, Canada. In Nat Rev Immunol, 2014
Through peptidoglycan recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 enable detection of intracellular bacteria and promote their clearance through initiation of a pro-inflammatory transcriptional programme and other host defence pathways, including autophagy.