Innate immunity in diabetes and diabetic nephropathy.
Okayama, Japan. In Nat Rev Nephrol, Jan 2016
The innate immune system includes several classes of pattern recognition receptors (PRRs), including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs).
Microarray and whole-exome sequencing analysis of familial Behçet's disease patients.
Suita, Japan. In Sci Rep, Dec 2015
They include heterozygous SNVs in the genes encoding IL-1 receptor-associated kinase 4 (IRAK4), nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain-containing 14 (NRP14) and melanoma antigen-encoding gene E2 (MAGEE2); IRAK4 harbors a missense mutation, whereas NRP14 and MAGEE2 harbor nonsense mutations.
Does Infection-Induced Immune Activation Contribute to Dementia?
Houston, United States. In Aging Dis, Sep 2015
Examples of PRR include toll-like receptors (TLR), receptors for advanced glycation endproducts (RAGE), nucleotide binding oligomerisation domain (NOD)-like receptors (NLR), c-type lectin receptors (CLR), RIG-I-like receptors (RLR), and intra-cytosolic DNA sensors.
More papers using
Tokyo, Japan. In Handb Clin Neurol, 2011
This sttudy suggested that age-dependent and CAG repeat-dependent intranuclear accumulation of mutant DRPLA leading to nuclear dysfunctions are suggested to be the essential pathophysiologic mechanisms in Dentatorubral-pallidoluysian atrophy.