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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CCR4 carbon catabolite repression 4-like

Noc, Nocturnin, Scutoid
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CLOCK, Neuropeptide, CAN, V1a, HAD
Papers on Noc
AtHESPERIN: A Novel Regulator of Circadian Rhythms with Poly(A)-degrading Activity in Plants.
Papadopoulou et al., Lárisa, Greece. In Rna Biol, Dec 2015
The gene is under circadian clock-gene regulation and has similarity to the mammalian Nocturnin.
Nucleoid occlusion protein Noc recruits DNA to the bacterial cell membrane.
Errington et al., Newcastle upon Tyne, United Kingdom. In Embo J, Mar 2015
In Bacillus subtilis, the nucleoid occlusion protein Noc binds to specific DNA sequences (NBSs) scattered around the chromosome and helps to protect genomic integrity by coupling the initiation of division to the progression of chromosome replication and segregation.
Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: prognostic value and impact on gene expression.
Balatsos et al., Lárisa, Greece. In Mol Cancer, 2014
Quantitative real-time PCR showed that four deadenylases, PARN, CNOT6, CNOT7 and NOC, are differentially expressed in our SCC clinical samples.
Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.
Green et al., Blacksburg, United States. In Sci Rep, 2014
Nocturnin (NOC) is a unique deadenylase with robustly rhythmic expression and loss of Noc in mice (Noc KO) results in resistance to diet-induced obesity.
Association between CLOCK, PER3 and CCRN4L with non‑small cell lung cancer in Brazilian patients.
Bastos-Rodrigues et al., Belo Horizonte, Brazil. In Mol Med Report, 2014
To investigate the association between clock genes and non‑small cell lung cancer (NSCLC), we genotyped three tag SNPs (rs938836, rs17050680, rs3805213) in the Nocturnin gene (CCRN4L), five SNPs (rs228727, rs228644, rs228729, rs707467, rs104620202) in the period 3 (PER3) gene and one SNP (rs6855837) in the CLOCK gene, in 78 Brazilian patients with NSCLC.
Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.
Desplan et al., Zürich, Switzerland. In Plos Genet, 2014
The elbow/no ocelli (elb/noc) complex of Drosophila melanogaster encodes two paralogs of the evolutionarily conserved NET family of zinc finger proteins.
Cell division in Corynebacterineae.
Bramkamp et al., Martinsried, Germany. In Front Microbiol, 2013
In many rod-shaped bacteria, precise midcell assembly of the division machinery relies on inhibitory systems such as Min and Noc.
A double-blind, placebo-controlled, parallel-group pilot study of milnacipran for chronic radicular pain (sciatica) associated with lumbosacral disc disease.
Patkar et al., Seoul, South Korea. In Prim Care Companion Cns Disord, 2013
Secondary outcome measures included nociceptive low back pain by visual analog scale (VAS-Noc), Oswestry Low Back Pain Disability Questionnaire, Neuropathic Pain Questionnaire, Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey, Beck Depression Inventory, and State-Trait Anxiety Inventory.
Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.
Wilusz et al., Fort Collins, United States. In Biochim Biophys Acta, 2013
PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells.
Chronic ethanol consumption disrupts the core molecular clock and diurnal rhythms of metabolic genes in the liver without affecting the suprachiasmatic nucleus.
Bailey et al., Birmingham, United States. In Plos One, 2012
Further, the diurnal oscillations of core clock genes (Bmal1, Clock, Cry1, Cry2, Per1, and Per2) and clock-controlled genes (Dbp, Hlf, Nocturnin, Npas2, Rev-erbα, and Tef) were altered in livers from ethanol-fed mice.
Clock regulation of dietary lipid absorption.
Pan et al., New York City, United States. In Curr Opin Clin Nutr Metab Care, 2012
PURPOSE OF REVIEW: To summarize the new knowledge about the regulation of dietary lipid absorption by circadian locomotor output cycles kaput (Clock) and Nocturnin.
Nocturnin: at the crossroads of clocks and metabolism.
Green et al., Dallas, United States. In Trends Endocrinol Metab, 2012
Nocturnin (Noc) is a robustly rhythmic gene that encodes a deadenylase thought to be involved in the removal of polyA tails from mRNAs.
RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway.
Shang et al., Beijing, China. In J Biol Chem, 2012
Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21-dependent and p53-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis.
An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.
Rosen et al., West Scarborough, United States. In Ann N Y Acad Sci, 2011
Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.
Green et al., Charlottesville, United States. In Curr Biol, 2011
Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Nocturnin expression is induced by fasting in the white adipose tissue of restricted fed mice.
Green et al., Charlottesville, United States. In Plos One, 2010
Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes
The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.
Green et al., Charlottesville, United States. In Plos One, 2010
data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis.
Errington et al., Oxford, United Kingdom. In Cell, 2004
We have identified a specific effector of nucleoid occlusion in Bacillus subtilis, Noc (YyaA), as an inhibitor of division that is also a nonspecific DNA binding protein.
Maturation and intranuclear transport of pre-ribosomes requires Noc proteins.
Tschochner et al., Heidelberg, Germany. In Cell, 2001
Mutation of each Noc protein impairs intranuclear transport of 60S subunits at different stages and inhibits pre-rRNA processing.
Innes et al., Ottawa, Canada. In Unknown Journal, 0001
Bevacizumab (Avastin), also derived from a recombinant humanized monoclonal IgG1 antibody that inhibits VEGF, is used clinically in the treatment of DME, although it does not have a Notice of Compliance (NoC) from Health Canada for this indication.
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