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NOBOX oogenesis homeobox

Nobox, OG2
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: GDF9, AGE, CAN, Osteocalcin, l-3
Papers using Nobox antibodies
Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging.
Supplier
Karl Mike O., In PLoS ONE, 2009
... NSCs were derived from OG2/ROSA26 heterozygous double transgenic mice, which were generated ...
Papers on Nobox
Gap junctions are essential for murine primordial follicle assembly immediately before birth.
New
Zhang et al., Beijing, China. In Reproduction, Feb 2016
In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes.
Oct4-GFP expression during transformation of gonocytes into spermatogonial stem cells in the perinatal mouse testis.
New
Hutson et al., Australia. In J Pediatr Surg, Dec 2015
MATERIALS AND METHODS: Testes from OG2 (Oct4-promoter driven eGFP) mice at embryonic day (E) 17 and postnatal day P0-10 underwent immunohistochemistry and immunoblotting.
Genetics of primary ovarian insufficiency: new developments and opportunities.
Review
New
Chen et al., Jinan, China. In Hum Reprod Update, Nov 2015
Based on candidate gene studies, single gene perturbations unequivocally having a deleterious effect in at least one population include Bone morphogenetic protein 15 (BMP15), Progesterone receptor membrane component 1 (PGRMC1), and Fragile X mental retardation 1 (FMR1) premutation on the X chromosome; Growth differentiation factor 9 (GDF9), Folliculogenesis specific bHLH transcription factor (FIGLA), Newborn ovary homeobox gene (NOBOX), Nuclear receptor subfamily 5, group A, member 1 (NR5A1) and Nanos homolog 3 (NANOS3) seem likely as well, but mostly being found in no more than 1-2% of a single population studied.
Testicular oocytes in MRL/MpJ mice possess similar morphological, genetic, and functional characteristics to ovarian oocytes.
New
Kon et al., Sapporo, Japan. In Mech Dev, Aug 2015
Germ cells with positive reactions to oogenesis markers such as NOBOX oogenesis homeobox and synaptonemal complex protein 3 were observed in the MRL/MpJ fetal testes on embryonic day 18.5.
Lats1 Deletion Causes Increased Germ Cell Apoptosis and Follicular Cysts in Mouse Ovaries.
New
Diaz et al., Syracuse, United States. In Biol Reprod, Jul 2015
Surprisingly, there was an increase in Bmp15 but not Gdf9, Figla, Nobox transcripts or the somatic-specific transcripts Amh and Wnt4 in cultured Lats1 mutant ovaries.
Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice.
New
Kon et al., In Jpn J Vet Res, Feb 2015
However, the beginning of folliculogenesis, as evidenced by the expression of NOBOX oogenesis homeobox (Nobox) transcript and protein, was more enhanced in MRL/MpJ mice than in C57BL/6 mice at embryonic day 18.5 and postnatal day 0. In addition, developed follicles were more frequently observed in MRL/MpJ mice than in C57BL/6 mice between postnatal days 0 and 4. In conclusion, the oocyte development during nest breakdown and folliculogenesis was accelerated in MRL/MpJ mice when compared to that observed in C57BL/6 mice.
GDF9 is transiently expressed in oocytes before follicle formation in the human fetal ovary and is regulated by a novel NOBOX transcript.
Anderson et al., Edinburgh, United Kingdom. In Plos One, 2014
In mice, the transcription factor Nobox is essential for follicle formation and oocyte survival, and NOBOX regulates the expression of GDF9 in humans.
Identification and Analysis of Regulatory Elements in Porcine Bone Morphogenetic Protein 15 Gene Promoter.
Wang et al., Xi'an, China. In Int J Mol Sci, 2014
The luciferase assays in combination with a series of deletion of BMP15 promoter sequence show that the -427 to -376 bp region of BMP15 promoter is the primary regulatory element, in which there are a number of transcription factor binding sites, including LIM homeobox 8 (LHX8), newborn ovary homeobox gene (NOBOX), and paired-like homeodomain transcription factor 1 (PITX1).
Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.
Rajkovic et al., Pittsburgh, United States. In Bmc Biol, 2014
Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure.
Adverse Effects of High Concentrations of Fluoride on Characteristics of the Ovary and Mature Oocyte of Mouse.
Zhang et al., China. In Plos One, 2014
The expression of genes, including Dazl, Stra8, Nobox, Sohlh1, and ZP3 gene, associated with oocyte formation were much lower in the experimental group as compared with the control group.
Oogenesis: transcriptional regulators and mouse models.
Review
Rajkovic et al., Pittsburgh, United States. In Mol Cell Endocrinol, 2012
These transcriptional regulators include: Foxo3, Foxl2, Figla, Lhx8, Nobox, Sohlh1 and Sohlh2.
Novel NOBOX loss-of-function mutations account for 6.2% of cases in a large primary ovarian insufficiency cohort.
GeneRIF
Binart et al., Le Kremlin-Bicêtre, France. In Hum Mutat, 2011
The very high 6.2% prevalence of these new mutations in POI patients suggest considering NOBOX as the first autosomal candidate gene involved in this syndrome.
Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown.
GeneRIF
Rajkovic et al., Kraków, Poland. In J Assist Reprod Genet, 2011
These results indicate that premature ovarian failure syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development.
The oocyte-specific transcription factor, Nobox, regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte.
GeneRIF
Choi et al., Seoul, South Korea. In Febs Lett, 2010
identified one Nobox DNA-binding element within the Pad6 promoter. findings indicate that Nobox is a critical regulator that orchestrates oocyte-specific genes such as Pad6 during folliculogenesis.
Determination and stability of gonadal sex.
Review
Pelosi et al., Baltimore, United States. In J Androl, 2010
In the germ line, oocytes apparently form normally even in the absence of Foxl2, dependent on genes that include female-specific factors such as Fig-alpha, Nobox, etc.
Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.
GeneRIF
Redi et al., Pavia, Italy. In Mol Reprod Dev, 2009
RT-PCR data shows an increase in oogenesis specific gene transcripts (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) between the primordial until the preantral stages, with the exception of the Oogenesin1 transcripts under gonadotropin-induction.
Premature ovarian failure and gene polymorphisms.
Review
Oldenburg et al., Rotterdam, Netherlands. In Curr Opin Obstet Gynecol, 2009
RECENT FINDINGS: Candidate gene approach revealed NOBOX, NR5A1, FIGLA and PGRMC1 as POI-genes.
Mutation analysis of NOBOX homeodomain in Chinese women with premature ovarian failure.
GeneRIF
Chen et al., Jinan, China. In Fertil Steril, 2009
Mutations in the homeobox domain of NOBOX are not common explanations for POF in Chinese women.
Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes.
Review
Simpson, Miami, United States. In Ann N Y Acad Sci, 2007
These include DNA binding proteins and transcription factors like NOBOX and LHX8, and RNA binding proteins like NANOS.
NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.
Impact
GeneRIF
Matzuk et al., Houston, United States. In Science, 2004
Nobox is critical for specifying an oocyte-restricted gene expression pattern essential for postnatal follicle development
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