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NIN1/RPN12 binding protein 1 homolog

NOB1, ART4, Nob1p
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010] (from NCBI)
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Top mentioned proteins: IL-1beta, CAN, Nin, Interleukin-2, HAD
Papers using NOB1 antibodies
Crystal structure of the eukaryotic ribosome
Supplier
Schleiff Enrico et al., In Nucleic Acids Research, 2009
... NMR resonance assignments for an archaeal homolog of the endonuclease Nob1 involved in ribosome biogenesisBiomol.
Papers on NOB1
miR-192 suppresses the tumorigenicity of prostate cancer cells by targeting and inhibiting nin one binding protein.
New
Huo et al., Luoyang, China. In Int J Mol Med, Feb 2016
UNASSIGNED: Nin one binding (NOB1) protein has been identified as an oncogene in various human cancers, including prostate cancer.
Systematic investigation of non-Boussinesq effects in variable-density groundwater flow simulations.
New
Graf et al., Hannover, Germany. In J Contam Hydrol, Dec 2015
The validity of three mathematical models describing variable-density groundwater flow is systematically evaluated: (i) a model which invokes the Oberbeck-Boussinesq approximation (OB approximation), (ii) a model of intermediate complexity (NOB1) and (iii) a model which solves the full set of equations (NOB2).
Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma.
New
Liu et al., Beijing, China. In Oncol Rep, Dec 2015
NIN1/RPN12 binding protein 1 homolog (NOB1) facilitates the maturation of the 20S proteasome and is then degraded by 26S proteasome to complete 26S proteasome biogenesis.
Sequencing of the ART4 gene in sub-Saharan cohorts reveals ethnic differences and two new DO alleles: DO*B-Ile5Thr and DO*B-Trp266Arg.
New
Chapel-Fernandes et al., Marseille, France. In Transfusion, Oct 2015
BACKGROUND: Given the high heterogeneity of sub-Saharan populations especially between nonpygmoids and pygmoids, differences are expected during investigation of the DO/ART4 gene.
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
New
Fischer et al., Düsseldorf, Germany. In Leuk Res, Sep 2015
Eleven novel translocations involved the genes ART4, C12orf60, MACROD2, TBL1XR1, LRRN4, KIAA1467, and ELMO1/MIR1200.
Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
New
Liu et al., Jinan, China. In Oncol Rep, Sep 2015
NIN/RPN12 binding protein 1 (NOB1p) encoded by NOB1 has been found to be an essential factor in 26S proteasome biogenesis which participates in protein degradation.
A novel DO null allele with a c.268C>T (p.Gln90Stop) mutation in Japanese.
New
Uchikawa et al., Tokyo, Japan. In Vox Sang, Aug 2015
Do(a) /Do(b) polymorphism is associated with c.793A>G (p.Asn265Asp) in exon 2 of the DO (ART4) gene, and the corresponding alleles are named DO*01 and DO*02.
NOB1 expression predicts early response to Cisplatin-based chemotherapy in patients with advanced non-small cell lung cancer.
New
You et al., In J Chemother, Jun 2015
BACKGROUND: The aim of this study was to investigate the predictive value of Nin one binding (NOB1) expression for response to cisplatin-based chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC).
MicroRNA-326 functions as a tumor suppressor in colorectal cancer by targeting the nin one binding protein.
New
Han et al., Xi'an, China. In Oncol Rep, May 2015
However, the specific function of miR-326 and its target the nin one binding protein (NOB1) in colorectal carcinoma (CRC) remains unclear.
EXPRESSION MECHANISM AND CLINICAL SIGNIFICANCE OF NOB1 IN GASTRIC CANCER TISSUE AND ADJACENT NORMAL TISSUE.
New
Liu et al., Zhengzhou, China. In J Biol Regul Homeost Agents, Apr 2015
This paper studies the effect and relationship of NOB1 in the development of gastric cancer, based on an analysis of NOB1expression in gastric cancer tissue and adjacent tissue.
NOB1 is essential for the survival of RKO colorectal cancer cells.
New
Liu et al., Shaoxing, China. In World J Gastroenterol, Feb 2015
AIM: To determine the role of NOB1, a regulator of cell survival in yeast, in human colorectal cancer cells.
Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells.
Cui et al., Changchun, China. In Int J Clin Exp Pathol, 2014
Our previously study demonstrated that downregulation of NOB1 (NIN1/RPN12 binding protein 1 homolog) expression by a lentiviral short hairpin RNA (shRNA) delivery system (Lv/sh-NOB1) suppressed ovarian cancer growth.
RNAi-mediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells.
GeneRIF
Cui et al., Changchun, China. In Med Oncol, 2012
These results suggested that NOB1 may act as an oncogenic factor in ovarian cancer
Downregulation of NIN/RPN12 binding protein inhibit the growth of human hepatocellular carcinoma cells.
GeneRIF
Lu et al., Shenyang, China. In Mol Biol Rep, 2012
Nob1 is an important regulator of the tumorigenic properties of human hepatocellular carcinoma and could be used as a candidate therapeutic target.
RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1.
GeneRIF
Hurt et al., Heidelberg, Germany. In J Biol Chem, 2010
Data report that cleavage of pre-rRNA at the 3'-end of 18 S rRNA, requires functional interactions between Nob1 and Prp43, and the cofactor Pfa1.
The Dombrock blood group system: a review.
Review
GeneRIF
Reid et al., New York City, United States. In Immunohematology, 2009
The Dombrock blood group system
Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain.
GeneRIF
Karbstein et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2009
Data demonstrate that Nob1's binding site centers around the 3'-end of 18S rRNA and also locate Nob1's suggested active site.
Complexities of the Dombrock blood group system revealed.
Review
Reid, New York City, United States. In Transfusion, 2005
This allowed determination of the molecular basis of the various Do phenotypes and the realization that DO is identical to the gene encoding a mono-ADP-ribosyltransferase, ART4.
Molecular genetics (HLA) of Behçet's disease.
Review
Ohno et al., Yokohama, Japan. In Yonsei Med J, 1997
Recently we sequenced a single contig of 236,822 bp from the MICA gene (58.2 kb centromeric of HLA-B) to 90.8 kb telomeric of HLA-C and identified 8 novel genes designated NOB1-8 (NOB: new organization associated with HLA-B).
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