Neuromedin U: a multifunctional neuropeptide with pleiotropic roles.
Dublin, Ireland. In Clin Chem, Mar 2015
BACKGROUND: Neuromedin U (NmU) belongs to the neuromedin family, comprising a series of neuropeptides involved in the gut-brain axis and including neuromedins B and C (bombesin-like), K (neurokinin B), L (neurokinin A or neurotensin), N, S, and U. CONTENT: Although initially isolated from porcine spinal cord on the basis of their ability to induce uterine smooth muscle contraction, these peptides have now been found to be expressed in several different tissues and have been ascribed numerous functions, from appetite regulation and energy balance control to muscle contraction and tumor progression.
Suppression of insulin production and secretion by a decretin hormone.
Stanford, United States. In Cell Metab, Mar 2015
Targeted knockdown of CG9918, a Drosophila ortholog of Neuromedin U receptors (NMURs), in insulin-producing cells phenocopied limostatin deficiency and attenuated insulin suppression by purified Lst, suggesting CG9918 encodes an Lst receptor.
Adaptive capacity to bacterial diet modulates aging in C. elegans.
Los Angeles, United States. In Cell Metab, 2014
Mechanistically, the alh-6 mutation triggers diet-induced mitochondrial defects and increased generation of ROS, likely due to accumulation of its substrate 1-pyrroline-5-carboxylate. We also identify that neuromedin U receptor signaling is essential for diet-induced mitochondrial changes and premature aging.
[Neuro-skeletal biology and its importance for clinical osteology].
Praha, Czech Republic. In Cesk Fysiol, 2011
This article reviews the neuro-hormonal factors with osteoanabolic (central isoform of serotonin, melatonin, cannabinoids, beta 1 adrenergic system, oxytocin, ACTH and TSH) or osteocatabolic effects (neuropeptide Y, neuromedin U, beta2 adrenergic system).
Orphan GPCRs and methods for identifying their ligands.
Suita, Japan. In Methods Enzymol, 2011
We subsequently identified ghrelin, neuromedin U, and neuromedin S as endogenous ligands of various orphan GPCRs and have proposed various mechanisms through which these peptides regulate physiological functions through their cognate GPCRs.
Bone remodeling, energy metabolism, and the molecular clock.
West Scarborough, United States. In Cell Metab, 2008
Two of the studies add to our knowledge of the complex hypothalamic modulation of bone turnover mediated by NMU and NPY via the sympathetic nervous system, while the other two focus on the peripheral neural target, the osteoblast, and its regulation by neuropeptides and osteocalcin.