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Zinc finger protein 384

NMP4, CIZ
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: Parathyroid Hormone, COL1A1, V1a, fibrillin-1, HAD
Papers on NMP4
Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
New
Ezura et al., Tokyo, Japan. In J Cell Biochem, Oct 2015
UNASSIGNED: CIZ/NMP4 (Cas interacting zinc finger protein, Nmp4, Zfp384) is a transcription factor that is known to regulate matrix related-proteins.
Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.
New
Bidwell et al., Bălţi, Moldova. In Mol Endocrinol, Sep 2015
Disabling the transcription factor nuclear matrix protein 4 (Nmp4) in healthy, ovary-intact mice enhances bone response to PTH and bone morphogenetic protein 2 and protects from unloading-induced osteopenia.
Activatable organic near-infrared fluorescent probes based on a bacteriochlorin platform: synthesis and multicolor in vivo imaging with a single excitation.
Kobayashi et al., Bethesda, United States. In Bioconjug Chem, 2014
In this study, we developed organic bacteriochlorin derivatives, NMP4 and NMP5, which are excited with a single green light and emit different narrow, well-resolved bands in the NIR (peak of 739 and 770 nm for NMP4 and NMP5, respectively).
Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency.
Yang et al., Indianapolis, United States. In Stem Cells Dev, 2013
We previously showed that disabling the transcription factor Nmp4/CIZ in mice expanded this anabolic window while modestly elevating bone resorption.
Formation and characterization of the nanoparticle-protein corona.
Dawson et al., Dublin, Ireland. In Methods Mol Biol, 2012
The NP corona consists of those proteins (and other biomolecules such as lipids and sugars) residing on the NP surface for a sufficient timescale to influence the NP's properties and interactions with living systems.
NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis.
Martel-Pelletier et al., In Arthritis Res Ther, 2012
rsmiR-140 showed activity and predicted binding sites for nuclear matrix transcription factor 4 (NMP4), myc-associated zinc (MAZ), nuclear factor of activated T-cells (NFAT), and mothers against decapentaplegic homolog 3 (SMAD3).
The core interthreshold zone during exposure to red and blue light.
Katsuura et al., In J Physiol Anthropol, 2012
BACKGROUND: This study tested the hypothesis that the core interthreshold zone (CIZ) changes during exposure to red or blue light via the non-visual pathway, because it is known that light intensity affects the central nervous system.
CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells.
Noda et al., Tokyo, Japan. In J Cell Physiol, 2012
CIZ/NMP4 is a nucleocytoplasmic shuttling protein and its roles in tumor cells have not been known.
Immortalization and characterization of osteoblast cell lines generated from wild-type and Nmp4-null mouse bone marrow stromal cells using murine telomerase reverse transcriptase (mTERT).
Bidwell et al., Indianapolis, United States. In J Cell Physiol, 2012
Intermittent parathyroid hormone (PTH) adds new bone to the osteoporotic skeleton; the transcription factor Nmp4/CIZ represses PTH-induced bone formation in mice and as a consequence is a potential drug target for improving hormone clinical efficacy.
Nmp4/CIZ closes the parathyroid hormone anabolic window.
Review
Yang et al., Indianapolis, United States. In Crit Rev Eukaryot Gene Expr, 2011
We have discovered that disabling the nucleocytoplasmic shuttling transcription factor nuclear matrix protein 4/cas interacting zinc finger protein (Nmp4/CIZ) in mice extends the PTH bone-forming capacity.
Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts.
Bidwell et al., Indianapolis, United States. In Calcif Tissue Int, 2011
Nmp4/CIZ is a nucleocytoplasmic shuttling transcriptional repressor that suppresses PTH-induced osteoblast gene expression and hormone-stimulated gains in murine femoral trabecular bone.
Identification of the TAF15-ZNF384 fusion gene in two new cases of acute lymphoblastic leukemia with a t(12;17)(p13;q12).
GeneRIF
Micci et al., Oslo, Norway. In Cancer Genet, 2011
Rare translocation t(12;17)(p13;q12), This translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases.
Functional characterization and analgesic effects of mixed cannabinoid receptor/T-type channel ligands.
Diaz et al., Calgary, Canada. In Mol Pain, 2010
Compound NMP-7 acted as non-selective CB1/CB2 agonist while NMP4 was found to be a CB1 partial agonist and CB2 inverse agonist.
Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts.
Pavalko et al., Indianapolis, United States. In J Cell Physiol, 2010
In this study we have for the first time examined the relationship between the nucleocytoplasmic shuttling transcription factor nuclear matrix protein-4/cas interacting zinc finger protein (Nmp4/CIZ) and beta-catenin signaling in response to a physiologic mechanical stimulation (oscillatory fluid shear stress, OFSS) in osteoblasts.
TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7.
GeneRIF
Li et al., Los Angeles, United States. In Biochem Biophys Res Commun, 2009
These results suggest that caspase-mediated degradation may represent a novel regulatory mechanism that controls TAF15 and TAF15-CIZ/NMP4 activities.
Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen.
GeneRIF
Noda et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2008
These results revealed that Ciz interacts with C-propeptides of type I collagen and this association takes place in nuclei.
CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients.
GeneRIF
Hagemeijer et al., In Leukemia, 2005
The CIZ protein(also known as ZNF384)was involved and rearrangemented in acute leukemia.
Identifying genes that regulate bone remodeling as potential therapeutic targets.
Review
Krane, Boston, United States. In J Exp Med, 2005
A newly described inhibitor of osteoblast differentiation, Ciz, interferes with bone morphogenic protein signaling.
Nmp4/CIZ regulation of matrix metalloproteinase 13 (MMP-13) response to parathyroid hormone in osteoblasts.
GeneRIF
Bidwell et al., Indianapolis, United States. In Am J Physiol Endocrinol Metab, 2004
Nmp4/CIZ is a component of a multiprotein assemblage or enhanceosome within the MMP-13 parathyroid hormone response region and that, within this context, Nmp4/CIZ promotes both basal expression and hormonal synergy.
Involvement of the nuclear matrix in the control of skeletal genes: the NMP1 (YY1), NMP2 (Cbfa1), and NMP4 (Nmp4/CIZ) transcription factors.
Review
Watt et al., Indianapolis, United States. In Crit Rev Eukaryot Gene Expr, 2000
In addressing how the nuclear matrix regulates skeletal genes, the authors compare Nmp4, Cbfal, and YY1 for the purpose of profiling osteoblast nuclear matrix transcription factors.
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