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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Glutamate receptor, ionotropic, N-methyl D-aspartate 1

NMDA receptor, gp130, NR1, NMDAR1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using NMDA receptor antibodies
CASK point mutation regulates protein-protein interactions and NR2b promoter activity
Grabowski Paula J. et al., In Journal of Nucleic Acids, 2008
... Treatment with NMDA receptor antagonists, MK801 and AP5 (Sigma Aldrich), was carried out by ...
A GluR1-cGKII interaction regulates AMPA receptor trafficking
Traynelis Stephen F. et al., In Nature neuroscience, 2006
... (IW), (S)-( −)-5-bromowillardiine (BW), (S)-willardiine (HW), (S)-CPW399 (CPW) and Cl-HIBO (CH), as well as DL-AP5 (NMDA receptor antagonist) and cyclothiazide (AMPA receptor desensitization blocker) were obtained from Tocris (Ellisville, MO) ...
Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
Siegel S J et al., In Translational Psychiatry, 2005
... NR1 transgenic mice were bred and ...
Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism
Rosenbaum Jean et al., In Comparative Hepatology, 2003
... Anti-gp130 mAb B-R3 was from Diaclone (Besançon, France), anti-gp80 mAb ...
The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells.
Abdelhay Eliana Saul Furquim Werneck, In PLoS ONE, 1999
... C57/BL6/J mice carrying loxP sites flanking exon 16 coding for the gp130 transmembrane domain were crossed with transgenic (tg) mice expressing Cre-recombinase ...
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Papers on NMDA receptor
LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria.
Suzuki et al., Tokyo, Japan. In Nucleic Acids Res, 2012
The LRPPRC/SLIRP complex suppressed 3' exonucleolytic mRNA degradation mediated by PNPase and SUV3.
Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.
Sprengel et al., Oxford, United Kingdom. In Nat Neurosci, 2012
Hippocampal Grin1 receptor enables the hippocampus to use spatial knowledge to select between alternative responses that arise from competing or overlapping memories in mice.
Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors.
Horak et al., Praha, Czech Republic. In J Biol Chem, 2012
key amino acid residues within both NR1 and NR2B M3 domains contribute to the regulation of the surface expression of unassembled NR1 and NR2 subunits
Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
Schlüter et al., Magdeburg, Germany. In Am J Pathol, 2012
These findings indicate a crucial protective function of gp130-expressing neurons in a model of chronic encephalitis.
Overstimulation of NMDA receptors impairs early brain development in vivo.
Tanaka et al., Tokyo, Japan. In Plos One, 2011
NR1 deletion in GLAST/GLT1 DKO mice almost completely rescued multiple brain defects including cortical, hippocampal, and olfactory bulb disorganization and defective corticothalamic and thalamocortical axonal projections.
More papers using NMDA receptor antibodies
Synaptic clustering of Fascilin II and Shakeressential targeting sequences and role of Dlg
Bredt David S. et al., In The Journal of Cell Biology, 1996
... ), and NR2B (Zymed) and monoclonal antibodies to PSD-95 (#046; Affinity Bioreagents), NR1 (PharMingen), GFP (Quantum, Clontech), HA epitope tag (BABCO), ...
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