The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (from
Traynelis Stephen F. et al., In Nature neuroscience, 2006
... (IW), (S)-( −)-5-bromowillardiine (BW), (S)-willardiine (HW), (S)-CPW399 (CPW) and Cl-HIBO (CH), as well as DL-AP5 (NMDA receptor antagonist) and cyclothiazide (AMPA receptor desensitization blocker) were obtained from Tocris (Ellisville, MO) ...
NR1 deletion in GLAST/GLT1 DKO mice almost completely rescued multiple brain defects including cortical, hippocampal, and olfactory bulb disorganization and defective corticothalamic and thalamocortical axonal projections.