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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Glutamate receptor, ionotropic, N-methyl D-aspartate 1

NMDA receptor, gp130, NR1, NMDAR1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HAD, NR2B
Papers using NMDA receptor antibodies
CASK point mutation regulates protein-protein interactions and NR2b promoter activity
Grabowski Paula J. et al., In Journal of Nucleic Acids, 2008
... Treatment with NMDA receptor antagonists, MK801 and AP5 (Sigma Aldrich), was carried out by ...
A GluR1-cGKII interaction regulates AMPA receptor trafficking
Traynelis Stephen F. et al., In Nature neuroscience, 2006
... (IW), (S)-( −)-5-bromowillardiine (BW), (S)-willardiine (HW), (S)-CPW399 (CPW) and Cl-HIBO (CH), as well as DL-AP5 (NMDA receptor antagonist) and cyclothiazide (AMPA receptor desensitization blocker) were obtained from Tocris (Ellisville, MO) ...
Adverse effects of risperidone on spatial working memory in first-episode schizophrenia
Siegel S J et al., In Translational Psychiatry, 2005
... NR1 transgenic mice were bred and ...
Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism
Rosenbaum Jean et al., In Comparative Hepatology, 2003
... Anti-gp130 mAb B-R3 was from Diaclone (Besançon, France), anti-gp80 mAb ...
The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells.
Abdelhay Eliana Saul Furquim Werneck, In PLoS ONE, 1999
... C57/BL6/J mice carrying loxP sites flanking exon 16 coding for the gp130 transmembrane domain were crossed with transgenic (tg) mice expressing Cre-recombinase ...
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Papers on NMDA receptor
NMDA receptor is involved in neuroinflammation in intracerebroventricular colchicine-injected rats.
Ghosh et al., Calcutta, India. In J Immunotoxicol, Feb 2016
It appears from the results that neuroinflammation might be linked with the NMDA receptor activity in ICIR rats and that this receptor is involved in the process of progressive neuroinflammation and neurodegeneration in the hippocampus of ICIR and potentially in immunomodulation in these same hosts.
Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
Snyder et al., Baltimore, United States. In Mol Psychiatry, Feb 2016
We report a novel signaling pathway wherein NMDA receptor activation stimulates generation of nitric oxide (NO), which S-nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
AChE inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of Alzheimer's disease.
Chen et al., Shanghai, China. In Curr Neuropharmacol, Feb 2016
Herein, we delineated the catalytic and non-catalytic functions of AChE, and summarized the works of our group and others in research and development of novel AChEI-based multi-target-directed ligands (MTDLs), such as dual binding site AChEIs and multi-target AChEIs inhibiting Aβ aggregation, regulating Aβ procession, antagonizing PAF receptor, scavenging oxygen radical, chelating metal ions, inhibiting MAO-B, blocking NMDA receptor and others.
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.
Do et al., Lausanne, Switzerland. In Nat Rev Neurosci, Feb 2016
Although the factors that trigger these deficits are diverse, there is increasing evidence that they converge on a common pathological hub that involves NMDA receptor hypofunction and oxidative stress.
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
Austin et al., Lewiston, United States. In Metallomics, Feb 2016
The zinc-finger proteins potentially impacted by lead include DNA methyltransferase 1 (DNMT1) and Presenilin 1 and 2 (PSEN1/2) in Alzheimer's disease, the dopamine receptor in Parkinson's disease, and the NMDA receptor, zinc-finger protein 804A (ZNF804A), and disrupted-in-schizophrenia 1 (DISC1)-binding zinc-finger (DBZ) in schizophrenia.
Antibodies to AMPA receptors in Rasmussen's encephalitis.
Lang et al., Bonn, Germany. In Eur J Paediatr Neurol, Feb 2016
To explore further, sera from 52 patients with Rasmussen's encephalitis were tested by cell-based assays for antibodies to AMPAR GluA1/2/3, N-methyl-d-aspartate (NMDA NR1/2b), γ-aminobutyric acid type A and B (GABAAR α1/γ2/β2 and GABABR b1/b2) receptors, for potassium channel complex proteins, and for binding to live cortical and hippocampal neuronal cultures.
New targets for rapid antidepressant action.
Zarate et al., Bethesda, United States. In Prog Neurobiol, Jan 2016
Since then, other NMDA receptor antagonists have been studied in MDD.
Long-term culture and expansion of primary human hepatocytes.
Nahmias et al., Jerusalem, Israel. In Nat Biotechnol, Dec 2015
We show that E6 and E7 expression upregulates the OSM receptor gp130 and that OSM stimulation induces hepatocytes to expand for up to 40 population doublings, producing 10(13) to 10(16) cells from a single human hepatocyte isolate.
Phencyclidine-induced disruption of oscillatory activity in prefrontal cortex: Effects of antipsychotic drugs and receptor ligands.
Celada et al., Barcelona, Spain. In Eur Neuropsychopharmacol, Dec 2015
UNASSIGNED: The non-competitive NMDA receptor (NMDA-R) antagonist phencyclidine (PCP) markedly disrupts thalamocortical activity, increasing excitatory neuron discharge and reducing low frequency oscillations (LFO, <4Hz) that temporarily group neuronal discharge.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Second, they promoted early T(FH) differentiation via the multipronged approach of sustaining expression of the cytokine receptors IL-6Rα and gp130, enhancing expression of the costimulatory receptor ICOS and promoting expression of the transcriptional repressor Bcl6.
Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Febbraio et al., Melbourne, Australia. In Cell Metab, Apr 2015
The pro-inflammatory effects of IL-6 are mediated via IL-6 "trans-signaling," a process where the soluble form of the IL-6 receptor (sIL-6R) binds IL-6 and activates signaling in inflammatory cells that express the gp130 but not the IL-6 receptor.
Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons.
Wyllie et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
UNLABELLED: Background GRIN2A encodes the GluN2A subunit of the NMDA receptor (NMDAR), an ionotropic glutamate receptor that has important roles in synaptogenesis and synaptic plasticity.
NMDA Receptor Function During Senescence: Implication on Cognitive Performance.
Kumar, Gainesville, United States. In Front Neurosci, 2014
One of the hallmarks of the aging human population is a decline in cognitive function; studies in the past couple of years have demonstrated deterioration in NMDA receptor subunit expression and function with advancing age.
On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors.
Sabo et al., Cleveland, United States. In Biomolecules, 2014
We discuss the evidence that NMDA receptor activation mediates these effects of glutamate and present the hypothesis that local activation of presynaptic NMDA receptors (preNMDARs) contributes to glutamate-dependent control of presynaptic development.
[Anti-N-methyl-D aspartate receptor encephalitis - guideline to the challenges of diagnosis and therapy].
Tényi et al., Pécs, Hungary. In Psychiatr Hung, 2014
During this disease antibodies are produced against the subunit of the NMDA receptor, which cause different symptoms, both psychiatric and neurological.
LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria.
Suzuki et al., Tokyo, Japan. In Nucleic Acids Res, 2012
The LRPPRC/SLIRP complex suppressed 3' exonucleolytic mRNA degradation mediated by PNPase and SUV3.
Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.
Sprengel et al., Oxford, United Kingdom. In Nat Neurosci, 2012
Hippocampal Grin1 receptor enables the hippocampus to use spatial knowledge to select between alternative responses that arise from competing or overlapping memories in mice.
Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of N-methyl-D-aspartate receptors.
Horak et al., Praha, Czech Republic. In J Biol Chem, 2012
key amino acid residues within both NR1 and NR2B M3 domains contribute to the regulation of the surface expression of unassembled NR1 and NR2 subunits
Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
Schlüter et al., Magdeburg, Germany. In Am J Pathol, 2012
These findings indicate a crucial protective function of gp130-expressing neurons in a model of chronic encephalitis.
Overstimulation of NMDA receptors impairs early brain development in vivo.
Tanaka et al., Tokyo, Japan. In Plos One, 2011
NR1 deletion in GLAST/GLT1 DKO mice almost completely rescued multiple brain defects including cortical, hippocampal, and olfactory bulb disorganization and defective corticothalamic and thalamocortical axonal projections.
More papers using NMDA receptor antibodies
Synaptic clustering of Fascilin II and Shakeressential targeting sequences and role of Dlg
Bredt David S. et al., In The Journal of Cell Biology, 1996
... ), and NR2B (Zymed) and monoclonal antibodies to PSD-95 (#046; Affinity Bioreagents), NR1 (PharMingen), GFP (Quantum, Clontech), HA epitope tag (BABCO), ...
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