gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Non-metastatic cells 1, protein

nm23, nm23-H1, Nucleoside-Diphosphate Kinase, NDP kinase
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: H1, CAN, HAD, p53, P18
Papers using nm23 antibodies
Expression of maspin is up-regulated during the progression of mammary ductal carcinoma
Supplier
Singh Rajinder et al., In Diagnostic Pathology, 2002
... The antibody used was rabbit anti-human monoclonal antibody nm23 at 1:40 dilution (DAKO).
Papers on nm23
NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy.
New
Schlattner et al., Pittsburgh, United States. In Cell Death Differ, Feb 2016
Here we demonstrate that a hexameric intermembrane space protein, NDPK-D (or NM23-H4), binds CL and facilitates its redistribution to the OMM.
Predictable factors for lymph node metastasis in early gastric cancer analysis of clinicopathologic factors and biological markers.
New
Zheng et al., Shanghai, China. In Tumour Biol, Feb 2016
We studied the relationship between clinicopathological factors, biological markers (p53, ki67, nm23, vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), E-cadherin (E-cad), beta-catenin (b-catenin), glutathione S-transferase (GST), and topoisomerase II (Topo II)), and LNM of EGC patients by chi-square test and logistic regression analysis.
Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells.
New
Wang et al., T'ai-chung-shih, Taiwan. In Oncotarget, Jan 2016
UNASSIGNED: Two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometry were performed to investigate the influence of human nonmetastatic clone 23 type 1 (nm23-H1), a metastasis-associated gene on proteomic alterations in cancer cells of the uterine cervix.
Nucleoside diphosphate kinases (NDPKs) in animal development.
Review
New
Mehta et al., Budapest, Hungary. In Cell Mol Life Sci, Apr 2015
NDPKs attracted more attention when NM23-H1 was identified as the first metastasis suppressor gene.
Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives.
Review
New
Wong et al., Hong Kong, Hong Kong. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Much attention has been focused on the better-known Nm23-H1, but despite having high sequence similarity, Nm23-H2 functions differently in many aspects.
Janus-faces of NME-oncoprotein interactions.
Review
New
Boyd et al., Liverpool, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Since the identification of Nm23 (NME1, NME/NM23 nucleoside diphosphate kinase 1) as the first non-metastatic protein, a great deal of research on members of the NME family of proteins has focused on roles in processes implicated in carcinogenesis and particularly their regulation of cellular motility and the process of metastatic spread.
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
Wang et al., T'ai-chung-shih, Taiwan. In Plos One, 2014
Further, cellular levels of protein kinase C epsilon type (PKC-ε) and kinesin heavy chain (KIF5B) increased with time of induction, whereas the level of NME/NM23 nucleoside diphosphate kinase 1 (Nm23-H1) decreased during the time course of differentiation.
Correlation between non-metastatic protein 23 expression and clinicopathological features of colorectal cancer in Asians.
Chu et al., Jining, China. In Genet Mol Res, 2014
The current meta-analysis was performed to investigate the association between non-metastatic protein 23 (NM23) expression, tumor pathology, and disease prognosis in colorectal cancer (CRC) among Asians.
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.
Review
Yegutkin, Turku, Finland. In Crit Rev Biochem Mol Biol, 2014
Along with "classical" inactivating ectoenzymes, recent data provide evidence for the co-existence of a counteracting ATP-regenerating pathway comprising the enzymes of the adenylate kinase (AK) and nucleoside diphosphate kinase (NDPK/NME/NM23) families and ATP synthase.
Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.
Impact
Chavrier et al., Paris, France. In Science, 2014
We found that knockdown of nucleoside diphosphate kinases (NDPKs) NM23-H1/H2, which produce GTP through adenosine triphosphate (ATP)-driven conversion of guanosine diphosphate (GDP), inhibited dynamin-mediated endocytosis.
The association of nm23-H1 expression with a poor prognosis in patients with peripheral T-cell lymphoma, not otherwise specified.
Review
Niitsu, Saitama, Japan. In J Clin Exp Hematop, 2013
nm23-H1 was originally identified as a protein that is expressed at a lower than usual level in metastatic cancer cells.
nm23 gene polymorphisms are associated with survival of patients with epithelial ovarian cancer but not with susceptibility to disease.
GeneRIF
Sun et al., Shijiazhuang, China. In Gynecol Oncol, 2012
Our studies suggest that rs16949649 and rs2302254 polymorphisms in the nm23 gene promoter may influence the prognosis of patients with epithelial ovarian cancer.
Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway.
GeneRIF
Jin et al., Shanghai, China. In Clin Immunol, 2012
Data suggest that TSLP might downregulate NME1 expression via STAT3 signaling pathway, affecting TIMP1 expression in influencing trophoblast invasion.
[Lentivirus-mediated stable silencing of nm23-H1 gene in lung cancer cells and the influence on biological behavior].
GeneRIF
Zhou et al., Tianjin, China. In Zhongguo Fei Ai Za Zhi, 2012
Downregulation of nm23-H1 gene expression enhanced the invasiveness compared with the controls.
The role of nm23 gene in colorectal carcinogenesis.
GeneRIF
Capkun et al., Split, Croatia. In Acta Clin Croat, 2012
higher expression of nm23 gene correlated with an early stage of tumor and its good differentiation
NM23HI as marker of metastasis in invasive ductal breast cancer.
GeneRIF
Rustamadji, Indonesia. In Acta Med Indones, 2012
ROC curve showed that NM23HI expression was a strongly correlated (r=0.816) sensitive and specific metastasis marker. NM23HI expression did not show asignificant relationship with histologic degree of invasive ductal carcinoma.
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.
Impact
Lieberman et al., Boston, United States. In Immunity, 2005
Granzyme A (GzmA) triggers cell death with apoptotic features by targeting the endoplasmic reticulum-associated SET complex, which contains the GzmA-activated DNase NM23-H1, its inhibitor SET, and Ape1.
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
Impact
Zollo et al., Napoli, Italy. In Cancer Cell, 2004
h-prune physically interacts with nm23-H1, a metastasis suppressor gene.
SET-ting the stage for life and death.
Review
Impact
Hong et al., Philadelphia, United States. In Cell, 2003
In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor.
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.
Impact
Lieberman et al., Boston, United States. In Cell, 2003
We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET.
share on facebooktweetadd +1mail to friends