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Non-metastatic cells 5, protein expressed in

Nm23-H5, Nme5
Top mentioned proteins: nm23, CAN, Nucleoside-Diphosphate Kinase, NMe3, ACID
Papers on Nm23-H5
Purine metabolism gene deregulation in Parkinson's disease.
Ferrer et al., Barcelona, Spain. In Neuropathol Appl Neurobiol, Dec 2015
METHODS: Analysis of mRNA using real-time quantitative PCR of 22 genes involved in purine metabolism in the substantia nigra, putamen and cerebral cortex area 8 in PD at different stages of disease progression, and localization of selected purine metabolism-related enzymes with immunohistochemistry. RESULTS: Reduced expression of adenylate kinase 2 (AKA2), AK3, AK4, adenine phosphoribosyltransferase, ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), ENTPD3, nonmetastatic cells 3, nucleoside-diphosphatese kinase 3 (NME1), NME7 and purine nucleoside phosphorylase 1 (PNP1) mRNA in the substantia nigra at stages 3-6; up-regulation of ADA mRNA in the frontal cortex area 8 at stages 3-4 and of AK1, AK5, NME4, NME5, NME6, 5'-nucleotidase (NT5E), PNP1 and prune homolog Drosophila at stages 5-6.
Deregulation of purine metabolism in Alzheimer's disease.
Ferrer et al., l'Hospitalet de Llobregat, Spain. In Neurobiol Aging, 2015
APRT, DGUOK, POLR3B, ENTPD3, AK5, NME1, NME3, NME5, NME7, and ENTPD2 messenger RNAs were deregulated, with regional variations, in AD cases when compared with controls.
Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma.
Helou et al., Göteborg, Sweden. In Int J Cancer, 2014
In the external gene expression dataset, six of the 13 genes (AZGP1, NME5, S100A8, SCUBE2, STC2 and UBE2C) retained their prognostic potential and were significantly associated with disease-free survival (p < 0.001).
Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells.
Zhang et al., Nanjing, China. In Gene, 2012
study characterized for the first time the human NME5 promoter which is controlled by Sp1 transcription factor in pancreatic cancer
Identification of NME5 as a contributor to innate resistance to gemcitabine in pancreatic cancer cells.
Zhang et al., Nanjing, China. In Febs J, 2012
NME5 was found to be highly expressed in an innate gemcitabine-resistant human pancreatic cancer sample and the cell line PAXC002 derived from the sample.
Congenital hydrocephalus in genetically engineered mice.
Zambrowicz et al., The Woodlands, United States. In Vet Pathol, 2012
Findings suggest that dysfunctional motile cilia represent the underlying pathogenetic mechanism in 8 of the 12 lines (Ulk4, Nme5, Nme7, Kif27, Stk36, Dpcd, Ak7, and Ak8).
Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis.
Somanath et al., Augusta, United States. In Bmc Cancer, 2011
Simvastatin treatment resulted in increased mRNA and protein expression of molecules such as TNF, Fas-L, Traf1 and cleaved caspase 8, major mediators of intrinsic apoptosis pathway and reduced protein levels of pro-survival genes Lhx4 and Nme5.
Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma.
Helou et al., Göteborg, Sweden. In Clin Cancer Res, 2010
In addition, more malignant tumors with normal gene dosage levels displayed a recurrent overexpression of UBE2C, S100A8, and CBX2, and downregulation of LOC389033, STC2, DNALI1, SCUBE2, NME5, SUSD3, SERPINA11, AZGP1, and PIP.
Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.
Kim et al., Seoul, South Korea. In Febs Lett, 2009
Previously, we cloned a new member of the NDPK family from mouse, Nm23-M5, which encodes a 211-amino acid protein and has 86% identity to the human Nm23-H5 [Hwang, K.C., Ok, D.W., Hong, J.C., Kim, M.O. and Kim, J.H. (2003) Cloning, sequencing, and characterization of the murine Nm23-M5 gene during mouse spermatogenesis and spermiogenesis.
Nme protein family evolutionary history, a vertebrate perspective.
Bobe et al., Rennes, France. In Bmc Evol Biol, 2008
Nme1, Nme2, Nme3, and Nme4 belong to Group I while vertebrate Nme5, Nme6, Nme7, Nme8, and Nme9 belong to Group II.
Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.
Knowles et al., Leeds, United Kingdom. In Mol Cancer Res, 2008
These genes (NME5, PSCA, TSPYL5, LY75, IGFBP2, IGF2, CEACAM6, XG, NOX5, KAL1, and HPGD) include eight previously identified as polycomb group targets.
Nm23/NDP kinases in human male germ cells: role in spermiogenesis and sperm motility?
Lacombe et al., Paris, France. In Exp Cell Res, 2003
found that Nm23-H5 and NDP kinases A and B are differently distributed in spermatids and mature spermatozoa and could therefore be involved at various levels of sperm differentiation and function
Cloning, sequencing, and characterization of the murine nm23-M5 gene during mouse spermatogenesis and spermiogenesis.
Kim et al., Chinju, South Korea. In Biochem Biophys Res Commun, 2003
By functional screening in yeast, we identified a new member of the NDPK family, nm23-M5, which encodes a 211-amino acid protein with 86% identity to the human homolog Nm23-H5.
The nucleoside diphosphate kinase activity of DRnm23 is not required for inhibition of differentiation and induction of apoptosis in 32Dcl3 myeloid precursor cells.
Calabretta et al., Philadelphia, United States. In Exp Cell Res, 2000
DRnm23 belongs to a multigene family which includes nm23-H1, the first bona fide metastasis suppressor gene, nm23-H2, nm23-H4, and nm23-H5.
A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells.
Lacombe et al., Paris, France. In Febs Lett, 1998
We have identified a cDNA encoding a 212 amino acid protein (Nm23-H5) with 27-31% identity to the human members of the nm23/nucleoside diphosphate (NDP) kinase gene family.
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