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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger protein 703

Nlz1, ZNF703, noz1
Top mentioned proteins: HAD, NET, FGFR1, c-Myc, Iris
Papers on Nlz1
Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study.
New
Stephens et al., Albany, United States. In Breast Cancer Res Treat, Feb 2016
Amplification of FGFR1 or ZNF703, located within the same amplicon, was found in 8 of 22 cases (36 %).
New transcription factors involved with postnatal ventral prostate gland development in male Wistar rats during the first week.
New
Carvalho et al., Campinas, Brazil. In Life Sci, Jan 2016
KEY FINDINGS: 16 TFs were studied and we found an increased expression of Eya2, Lhrh and Znf142, invariable levels of Znf703 and Dbp, and decreased expression of 11 others at postnatal development day 3 and 6 as compared to day zero.
nlz1 is required for cilia formation in zebrafish embryogenesis.
New
Brooks et al., Bethesda, United States. In Dev Biol, Nov 2015
In this report we describe a novel role of the Nlz1 protein in ciliogenesis.
Immunohistochemical and molecular profiling of histologically defined apocrine carcinomas of the breast.
New
Sapino et al., Torino, Italy. In Hum Pathol, Sep 2015
MLPA assay revealed gene copy gains of MYC, CCND1, ZNF703, CDH1, and TRAF4 in 50% or greater of the apocrine carcinomas, whereas gene copy losses frequently affected BRCA2 (75%), ADAM9 (54%), and BRCA1 (46%).
Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine.
New
O'Shaughnessy et al., Albany, United States. In Cancer Med, Aug 2015
Mutations in PIK3CA, amplifications of FGFR1 or ZNF703, or phosphorylation of HER family receptors and their downstream proteins did not preclude exceptional responses to capecitabine.
Engineering targeted chromosomal amplifications in human breast epithelial cells.
New
Lauring et al., Baltimore, United States. In Breast Cancer Res Treat, Jul 2015
We used adeno-associated virus vectors to target human MCF-7 breast cancer cells at the ZNF703 locus, in the recurrent 8p11-12 amplicon, using the E. coli inosine monophosphate dehydrogenase (IMPDH) enzyme as a marker.
Elevated ZNF703 Protein Expression Is an Independent Unfavorable Prognostic Factor for Survival of the Patients with Head and Neck Squamous Cell Carcinoma.
Shi et al., Guangzhou, China. In Dis Markers, 2014
AIM: Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC).
Fibroblast growth factor family aberrations in cancers: clinical and molecular characteristics.
Kurzrock et al., San Diego, United States. In Cell Cycle, 2014
In multivariate analysis, FGF/FGFR abnormalities were independently associated with CCND1/2, RICTOR, ZNF703, RPTOR, AKT2, and CDK8 alterations (all P < 0.02), as well as with an increased median number of alterations (P < 0.0001).
Amplification of chromosome 8 genes in lung cancer.
Dalay et al., İstanbul, Turkey. In J Cancer, 2014
The most frequently amplified genes were ZNF703, PRDM14 and MYC on chromosome 8 and the BIRC5 gene on chromosome 17.
The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression.
Shu et al., Nanjing, China. In Mol Cancer, 2014
Furthermore, we discovered that ZNF703 was a target of SPRY4-IT1 and was downregulated by SPRY4-IT1 knockdown.
ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer.
Zhang et al., Guangzhou, China. In Oncol Rep, 2014
Zinc finger protein 703 (ZNF703), identified as an oncogene in luminal B breast cancer, is a member of the NET/NlZ family of zinc finger transcription factors.
ZNF703 acts as an oncogene that promotes progression in gastric cancer.
Zhang et al., Guangzhou, China. In Oncol Rep, 2014
ZNF703, a member of the NET/Nlz family of zinc finger transcription factors, contributes to aspects of developmental growth and patterning across evolutionarily diverse species.
Concurrent MCL1 and JUN amplification in pseudomyxoma peritonei: a comprehensive genetic profiling and survival analysis.
Miller et al., Rochester, United States. In J Hum Genet, 2014
ZNF703 was amplified in one patient.
Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.
Desplan et al., Zürich, Switzerland. In Plos Genet, 2014
Vertebrate NET proteins play an important role in the developing nervous system, and mutations in the homolog ZNF703 human promote luminal breast cancer.
aldh7a1 regulates eye and limb development in zebrafish.
Brooks et al., Bethesda, United States. In Plos One, 2013
We show that morpholino knockdown of aldh7a1 in zebrafish causes uveal coloboma and misregulation of nlz1, another known contributor to the coloboma phenotype, as well as skeletal abnormalities.
ZNF703 gene amplification at 8p12 specifies luminal B breast cancer.
GeneRIF
Ginestier et al., Marseille, France. In Embo Mol Med, 2011
ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells.
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
GeneRIF
Caldas et al., Cambridge, United Kingdom. In Embo Mol Med, 2011
These data strongly point to ZNF703 as a novel oncogene in Luminal B breast cancer.
Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.
GeneRIF
Albertson et al., San Francisco, United States. In Oncogene, 2009
Data show that FGFR1 and DDHD2 at 8p12 cooperated functionally with MYC, whereas CCND1 and ZNF703 cooperated with a dominant negative form of TP53.
Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure.
GeneRIF
Brooks et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2009
identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure
Nlz1/Znf703 acts as a repressor of transcription.
GeneRIF
Sagerström et al., Worcester, United States. In Bmc Dev Biol, 2007
Nlz1/Znf703 acts as a repressor of transcription
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