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NK2 transcription factor related, locus 2

Nkx2.2, Nkx2-2
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Insulin, CAN, Ngn3, PDX-1, Glucagon
Papers on Nkx2.2
Generation of functional human serotonergic neurons from fibroblasts.
New
Gage et al., Los Angeles, United States. In Mol Psychiatry, Jan 2016
We found that overexpressing the transcription factors NKX2.2,
CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas.
New
Kawai et al., Tokyo, Japan. In Am J Surg Pathol, Jan 2016
Distinguishing immunohistochemical features included heterogenous CD99 reactivity, nuclear WT1 expression, and calretinin expression in the CIC-rearranged sarcomas and NKX2.2 expression in the Ewing sarcomas.
Wnt9a deficiency discloses a repressive role of Tcf7l2 on endocrine differentiation in the embryonic pancreas.
New
Gasa et al., Barcelona, Spain. In Sci Rep, Dec 2015
We identify the gene encoding the endocrine transcription factor Nkx2-2 as one of the most upregulated genes in Wnt9a-ablated pancreases and associate its activation to reduced expression of the Wnt effector Tcf7l2.
Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain.
New
de la Monte et al., Providence, United States. In Alcohol Alcohol, Nov 2015
Ethanol- and NNK-associated increases in FOXO1, FOXO4 and NKX2-2 transcription factor gene expression could reflect compensatory responses to brain insulin resistance in this model.
Development of the pancreas in medaka, Oryzias latipes, from embryo to adult.
New
Takeda et al., Tokyo, Japan. In Dev Growth Differ, Oct 2015
The markers used in these analyses included pdx1, nkx6.1, nkx6.2, nkx2.2,
The Role of ARX in Human Pancreatic Endocrine Specification.
Kieffer et al., Vancouver, Canada. In Plos One, 2014
Differentiated ARX knockout cells upregulated PAX4, NKX2.2, ISL1, HHEX, PCSK1, PCSK2 expression while downregulating PAX6 and IRX2.
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
Impact
Hattersley et al., Albuquerque, United States. In Cell Metab, 2014
We identified homozygous mutations in 7 different genes in 11 unrelated patients and show that NKX2-2 and MNX1 are etiological genes for neonatal diabetes, thus confirming their key role in development of the human pancreas.
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.
Impact
Goldman et al., Rochester, United States. In Cell Stem Cell, 2013
From three hiPSC lines, as well as from human embryonic stem cells (hESCs), we generated highly enriched OLIG2(+)/PDGFRα(+)/NKX2.2(+)/SOX10(+) human OPCs, which could be further purified using fluorescence-activated cell sorting.
NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma.
GeneRIF
Tsuda et al., Tokyo, Japan. In Am J Surg Pathol, 2012
NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.
GeneRIF
Nazarali et al., Saskatoon, Canada. In J Mol Cell Biol, 2011
Sirt2 enhances CG4 oligodendroglial differentiation and report a novel mechanism through which Nkx2.2 represses CG4 oligodendroglial differentiation via Sirt2.
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
GeneRIF
Sussel et al., New York City, United States. In Dev Biol, 2011
these experiments identify novel genetic interactions between Nkx2.2 and Arx within the endocrine progenitor cells that ensure the correct specification and regulation of endocrine hormone-producing cells
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.
GeneRIF
Sussel et al., New York City, United States. In Genes Dev, 2011
Mutation of the endogenous Nkx2.2 tinman (TN) domain in mice abolishes the interaction between Nkx2.2 and Grg3 and disrupts beta-cell specification
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.
Impact
GeneRIF
Meijerink et al., Rotterdam, Netherlands. In Cancer Cell, 2011
NKX2-1, NKX2-2, and MEF2C define oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL).
Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.
GeneRIF
Serup et al., Göttingen, Germany. In Bmc Dev Biol, 2010
Nkx2.2 acts by reinforcing the transcriptional networks initiated by Pax4 and Arx in early committed beta- and alpha-cell, respectively.
Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells.
Review
Owens et al., Charlottesville, United States. In Stem Cells, 2007
Results of recent studies indicate that a novel "bivalent" chromatin structure marks key developmental genes in embryonic stem cells (ESCs), wherein a number of untranscribed lineage-control genes, such as Sox1, Nkx2-2, Msx1, Irx3, and Pax3, are epigenetically modified with a unique combination of activating and repressive histone modifications that prime them for potential activation (or repression) upon cell lineage induction and differentiation.
A Wnt signal regulates stem cell fate and differentiation in vivo.
Review
Wurst et al., München, Germany. In Neurodegener Dis, 2006
Recently, substantial advances have been made by demonstrating that the secreted molecule Wnt1 regulates a genetic network, including the transcription factors Otx2 and Nkx2-2, for the initial establishment of the dopaminergic progenitor domain in the mammalian ventral midbrain.
Genetic networks controlling the development of midbrain dopaminergic neurons.
Review
Wurst et al., München, Germany. In J Physiol, 2006
Firstly, a Wnt1-regulated genetic network, including Otx2 and Nkx2-2, and a Shh-controlled genetic cascade, including Lmx1a, Msx1 and Nkx6-1, have been unravelled, acting in parallel or sequentially to establish a territory competent for midbrain dopaminergic precursor production at relatively early stages of neural development.
Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations.
Impact
Turner et al., Birmingham, United Kingdom. In Nat Genet, 2006
Studies on genes silenced in both ICM and ES cells (Cdx2, Cfc1, Hhex and Nkx2-2, also known as Nkx) show that the intensity of silencing marks is relatively diminished in ES cells, indicating a possible relaxation of some components of silencing on adaptation to culture.
Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.
Impact
GeneRIF
Lessnick et al., Salt Lake City, United States. In Cancer Cell, 2006
Functional analysis revealed that NKX2.2 is an EWS/FLI-regulated gene that is necessary for oncogenic transformation in Ewing's sarcoma.
Minireview: transcriptional regulation in pancreatic development.
Review
Thomas et al., Boston, United States. In Endocrinology, 2005
Disruption of transcription factor genes expressed more downstream in the developmental cascade (Beta2/NeuroD, Pax4, NKx2.2, and Nkx6.1) curtails the formation of insulin-producing beta-cells.
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