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NK2 transcription factor related, locus 3

NKX2-3, Nkx2.3
This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010] (from NCBI)
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Top mentioned proteins: IBD, TCPTP, IL23R, ATG16L1, NOD2
Papers on NKX2-3
Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing.
New
Fisher et al., Baltimore, United States. In Physiol Rep, Jul 2015
Unique transcriptional control in MA smooth muscle is suggested by the selective or enriched expression of transcription factors Nkx2-3, HAND2, and Tcf21 (Capsulin).
Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.
New
IBD Study Group of the Korean Association for the Study of Intestinal Diseases (KASID) et al., Seoul, South Korea. In Gut, Apr 2015
NKX2-3 (rs888208, OR=0.82, p=6.37×10(-4)) and DNAH12 (rs4462937, OR=1.13, p=3.17×10(-2)).
Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.
Song et al., Seoul, South Korea. In Inflamm Bowel Dis, 2015
NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32),
Transcriptome Profiling of Pediatric Core Binding Factor AML.
Meshinchi et al., Huntsville, United States. In Plos One, 2014
Clustering of differentially expressed genes indicated that the homeobox (HOX) gene family, including two transcription factors (MEIS1 and NKX2-3) were down-regulated in CBF compared to NK samples.
Absence of Nkx2-3 homeodomain transcription factor reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.
Balogh et al., Pécs, Hungary. In J Immunol, 2014
In this study, we report that Nkx2-3-deficient mice show gradual loss of MAdCAM-1 in PPs postnatally and increased levels of mRNA for peripheral lymph node addressin (PNAd) backbone proteins as well as enhanced expression of MECA79 sulfated glycoepitope at the luminal aspect of HEVs, thus replacing MAdCAM-1 with PNAd.
Characteristics of Japanese inflammatory bowel disease susceptibility loci.
Review
Shinomura et al., Sapporo, Japan. In J Gastroenterol, 2014
RESULTS: We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
Global hypomethylation and promoter methylation in small intestinal neuroendocrine tumors: an in vivo and in vitro study.
Larsson et al., Stockholm, Sweden. In Epigenetics, 2014
Promoter methylation was observed for WIF1, RASSF1A, CTNNB1, CXCL14, NKX2-3, P16, LAMA1, and CDH1.
Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.
Li et al., Nanjing, China. In Sci Rep, 2013
Polymorphisms in NKX2-3 gene have been inconsistently associated with Crohn's disease (CD) and ulcerative colitis (UC).
Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1.
GeneRIF
Koltun et al., Colón, Panama. In Inflammation, 2012
NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1.
PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
GeneRIF
Lin et al., United States. In Dis Markers, 2011
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients.
New IBD genetics: common pathways with other diseases.
Review
Satsangi et al., Edinburgh, United Kingdom. In Gut, 2011
Amongst these are multiple genes involved in IL23/Th17 signalling (IL23R, IL12B, JAK2, TYK2 and STAT3), IL10, IL1R2, REL, CARD9, NKX2.3, ICOSLG, PRDM1, SMAD3 and ORMDL3.
NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT.
GeneRIF
Lin et al., United States. In Mol Genet Metab, 2011
The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay.
Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen.
GeneRIF
Balogh et al., Pécs, Hungary. In J Histochem Cytochem, 2011
The splenic vascular defects in Nkx2-3 deficiency include the generation of LYVE-1(+) cysts, comprised of endothelial cells without being committed along the LEC lineage.
NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells.
GeneRIF
Lin et al., United States. In Plos One, 2010
NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells.
The genetics of Crohn's disease.
Review
Satsangi et al., Edinburgh, United Kingdom. In Annu Rev Genomics Hum Genet, 2008
These loci encode genes involved in a number of homeostatic mechanisms: innate pattern recognition receptors (NOD2/CARD15, TLR4, CARD9), the differentiation of Th17-lymphocytes (IL-23R, JAK2, STAT3, CCR6, ICOSLG), autophagy (ATG16L1, IRGM, LRRK2), maintenance of epithelial barrier integrity (IBD5, DLG5, PTGER4, ITLN1, DMBT1, XBP1), and the orchestration of the secondary immune response (HLA-region, TNFSF15/TL1A, IRF5, PTPN2, PTPN22, NKX2-3, IL-12B, IL-18RAP, MST1).
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
Impact
Satsangi et al., London, United Kingdom. In Nat Genet, 2008
We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.
Impact
GeneRIF
Schreiber et al., Kiel, Germany. In Nat Genet, 2008
Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis
The genetics and immunopathogenesis of inflammatory bowel disease.
Review
Impact
Cho, New Haven, United States. In Nat Rev Immunol, 2008
By contrast, variation in the gene encoding the interleukin-23 (IL-23) receptor subunit, as well as in the IL12B, STAT3 and NKX2-3 gene regions, is associated with both Crohn's disease and ulcerative colitis.
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
Impact
Mathew et al., Cambridge, United Kingdom. In Nat Genet, 2007
We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.
Abnormal lymphoid organ development in immunodeficient mutant mice.
Review
Hogenesch et al., West Lafayette, United States. In Vet Pathol, 2006
The Tlx1, Bapx1, Tcf21, Wt1 and Dh genes are essential for development of the spleen, while mutations of Nkx2-3, Lta, Ltb, Ltbr, Map3k14, Relb, Tnf, Tnfrsf1a, Cxcl13, Blr1 (Cxcr5), or cpdm genes result in disruption of normal splenic microarchitecture.
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