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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Killer cell lectin-like receptor subfamily F, member 1

NKp80, M-L, KLRF1
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: NKG2D, NKp30, NKp46, AICL, NKp44
Papers on NKp80
A novel method to expand large numbers of CD56(+) natural killer cells from a minute fraction of selectively accessed cryopreserved cord blood for immunotherapy after transplantation.
New
Childs et al., Columbus, United States. In Cytotherapy, Nov 2015
These cells expressed high levels of CD161, LFA-1, CD69, NKG2D, NKp30, NKp44, NKp80 and NKp46.
HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity.
New
Kellner et al., Kiel, Germany. In Oncotarget, Nov 2015
To increase the recognition of tumor cells, the extracellular domains of ligands of the activating NK cell receptors NKp30, NKp80 and DNAM-1 (i.e.
Generation and preclinical characterization of an NKp80-Fc fusion protein for redirected cytolysis of natural killer (NK) cells against leukemia.
New
Sun et al., Hefei, China. In J Biol Chem, Oct 2015
Given that activation-induced C-type lectin (AICL), an identified ligand for the NK-activating receptor NKp80, is frequently highly expressed on leukemia cells, the lack of therapeutic AICL-specific antibodies limits clinical application.
Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy.
New
Lye et al., Toronto, Canada. In Cell Mol Immunol, Sep 2015
Although the frequency of CD56(+)CD16(-) dNK among the total CD45(+) leukocytes did not change over this period, the expression of the activating receptors, NKp80 and NKG2D, was greatly upregulated.
Mucosal-associated invariant T cell is a potential marker to distinguish fibromyalgia syndrome from arthritis.
Wakao et al., Sapporo, Japan. In Plos One, 2014
Among the cell surface antigens in MAIT cells, three chemokine receptors, CCR4, CCR7, and CXCR1, a natural killer (NK) receptor, NKp80, a signaling lymphocyte associated molecule (SLAM) family, CD150, a degrunulation marker, CD107a, and a coreceptor, CD8β emerged as potential biomarkers for FMS to distinguish from HD.
Compromised natural killer cells in pulmonary embolism.
Wang et al., Shanghai, China. In Int J Clin Exp Pathol, 2014
RESULTS: In the present study, based on gene expression microarray analysis, we showed four inhibitory receptors (KLRB1, KLRD1, KLRF1, KLRG1) and four activating receptors (KLRC1, KLRC3, KLRK1 and NCR1) on NK cells were remarkably down-regulated and the cytological experiment demonstrated the proportion of CD16+CD56+ NK cells among PBMCs decreased in the PE group.
Bioinformatics analysis of gene expression in peripheral blood mononuclear cells from children with type 1 diabetes in 3 periods.
Wang et al., Jinan, China. In Exp Clin Endocrinol Diabetes, 2014
The cluster analysis of these DEGs showed that 4 genes, including human leukocyte antigen (HLA-DQA1), HLA-DRB4, integrin 3 (ITGB3) and killer cell lectin-like receptor subfamily F member 1 (KLRF1) were all significantly expressed in 3 groups, which were significantly enriched in asthma, T1D and intestinal immune network for IgA production pathway.
hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo.
Zhang et al., Jinan, China. In Immunobiology, 2014
Further investigation showed that NKL-IL15 cells expressed much higher levels of cytolysis-related molecules, including NKp80, TRAIL, granzyme B, IFN-γ, and TNF-α, than parental NKL cells in response to HCC stimulation.
Identification of novel molecular markers for prognosis estimation of acute myeloid leukemia: over-expression of PDCD7, FIS1 and Ang2 may indicate poor prognosis in pretreatment patients with acute myeloid leukemia.
Meng et al., Guangzhou, China. In Plos One, 2013
For further improving the prognosis evaluation system, we investigated the transcripts levels of PDCD7, FIS1, FAM3A, CA6, APP, KLRF1, ATCAY, GGT5 and Ang2 in 97 AML patients and 30 non-malignant controls, and validated using the published microarray data from 225 cytogenetically normal AML (CN-AML) patients treated according to the German AMLCG-1999 protocol.
Structural basis for recognition of cellular and viral ligands by NK cell receptors.
Review
Mariuzza et al., Rockville, United States. In Front Immunol, 2013
A growing number of NK receptor-ligand interaction pairs involving non-MHC molecules have also been identified, including NKp30-B7-H6, killer cell lectin-like receptor G1-cadherin, and NKp80-AICL.
Regulation of self-ligands for activating natural killer cell receptors.
Review
Gasser et al., Singapore, Singapore. In Ann Med, 2013
We review numerous pathways that have been implicated in the regulation of self-ligands for activating receptors, including NKG2D, DNAM-1, LFA-1, NKp30, NKp44, NKp46, NKp65, and NKp80 found on NK cells and some T cells.
Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex.
Review
Steinle et al., Frankfurt am Main, Germany. In Front Immunol, 2012
The prototypic mouse NKRP1 receptor is Nkrp1c (also known as NK1.1), while human members of the NKRP1 subfamily are NKRP1A, NKp80, and NKp65.
Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity.
GeneRIF
Steinle et al., Tübingen, Germany. In J Immunol, 2011
Activating receptor NKp80 induces cytotoxicity by using an atypical hemi-ITAM amino acid seqeuence and the Syk-kinase pathway.
NKp80 defines and stimulates a reactive subset of CD8 T cells.
GeneRIF
Steinle et al., Tübingen, Germany. In Blood, 2009
NKp80 is expressed on a highly responsive subset of effector memory CD8 T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL-expressing cells.
Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction.
Impact
Steinle et al., Tübingen, Germany. In Nat Immunol, 2006
However, the function and ligand(s) of the NK cell gene complex-encoded human NK cell receptor NKp80 remain elusive.
Human natural killer cell receptors and co-receptors.
Review
Moretta et al., Genova, Italy. In Immunol Rev, 2001
However, the process of NK-cell triggering during target cell lysis may also depend on the concerted action of NCR and other triggering receptors, such as NKG2D, or surface molecules, including 2B4 and NKp80, that appear to function as co-receptors rather than as true receptors.
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Review
Impact
Moretta et al., Genova, Italy. In Annu Rev Immunol, 2000
Other triggering surface molecules including 2B4 and the novel NKp80 appear to function as coreceptors rather than as true receptors.
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