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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Natural cytotoxicity triggering receptor 1

NKp46, AR1
has similarity to immunoglobulins; expressed in NK cells [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NKp30, NKG2D, NKp44, CAN, HAD
Papers on NKp46
Complementarity and redundancy of IL-22-producing innate lymphoid cells.
New
Impact
Vivier et al., Melbourne, Australia. In Nat Immunol, Feb 2016
Within the gut, ILC3 subsets coexist that either express or lack the natural cytoxicity receptor (NCR) NKp46.
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
New
Impact
Zhu et al., Bethesda, United States. In Nat Immunol, Feb 2016
In addition, GATA-3 served a critical function in the development of the NKp46(+) ILC3 subset by regulating the balance between the transcription factors T-bet and RORγt.
Effect of Indoleamine 2,3-Dioxygenase Expressed in HTR-8/SVneo Cells on Decidual NK Cell Cytotoxicity.
New
Qu et al., China. In Am J Reprod Immunol, Feb 2016
PROBLEM: To study the effect of indoleamine 2,3-dioxygenase (IDO) expressed in HTR-8/SVneo cells on NKG2D and NKp46 expression and cytotoxicity of decidual NK (dNK) and peripheral NK (pNK) cells.
Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure.
New
Haczku et al., Philadelphia, United States. In J Immunol, Feb 2016
Because NKp46, a glycosylated membrane receptor, was necessary for dose-dependent SP-D binding to NK cells in vitro and DC migration in vivo, we speculate that SP-D may constitutively stimulate IFN-γ production by NK cells, possibly via NKp46.
NK Cell-Specific Gata3 Ablation Identifies the Maturation Program Required for Bone Marrow Exit and Control of Proliferation.
New
Lee et al., Ottawa, Canada. In J Immunol, Feb 2016
Using NKp46-Cre-Gata3(fl/fl) mice in which Gata3 deficiency was induced as early as the immature stage of NK cell differentiation, we demonstrated that GATA3 is required for the NK cell maturation beyond the CD27 single-positive stage and is indispensable for the maintenance of liver-resident NK cells.
Differentiation and function of group 3 innate lymphoid cells, from embryo to adult.
Review
New
Vivier et al., Marseille, France. In Int Immunol, Jan 2016
ILC3 can be divided into two major subsets based on the cell surface expression of the natural cytotoxicity receptor (NCR), NKp46.
Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation.
New
Ohdan et al., Hiroshima, Japan. In Transplantation, Jan 2016
BACKGROUND: NKp46 expression in natural killer (NK) cells has recently been shown to affect the responsiveness to antiviral treatment in hepatitis C virus (HCV)-infected patients.
Lessons from NK Cell Deficiencies in the Mouse.
Review
New
Kerdiles et al., Marseille, France. In Curr Top Microbiol Immunol, Oct 2015
More recently, large-scale gene-expression analyses allowed the identification of NKp46 as one of the best markers of NK cells across mammalian species.
Development, Homeostasis, and Heterogeneity of NK Cells and ILC1.
Review
New
Huntington et al., Australia. In Curr Top Microbiol Immunol, Sep 2015
NK cells have previously been viewed to represent a relatively homogeneous group of IFN-γ-producing cells that express the surface markers NK1.1 and natural killer cell p46-related protein (NKp46 or NCR1 encoded by Ncr1) and depend on the transcription factor T-bet for their development.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
New
Impact
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
Mononuclear cells were isolated by ficoll separation and cell surface staining performed for CD3, CD56, CD16, CD57, CD117, CD161, CD158a, CD158b, CD49a, CD49b, CXCR6, NKG2C, and NKp46.
A late-surviving apatemyid (Mammalia: Apatotheria) from the latest Oligocene of Florida, USA.
Morgan et al., Norman, United States. In Peerj, 2014
The new species from Florida significantly extends this temporal range by roughly 5 Ma to the end of the Paleogene near the Oligocene-Miocene boundary (from early Arikareean, Ar1, to late Arikareean, Ar3), and greatly extends the geographic range of the family into eastern North America some 10° of latitude farther south and 20° of longitude farther east (about 2,200 km farther southeast) than previously known.
Functional Alteration of Natural Killer Cells and Cytotoxic T Lymphocytes upon Asbestos Exposure and in Malignant Mesothelioma Patients.
Review
Otsuki et al., Kurashiki, Japan. In Biomed Res Int, 2014
It is interesting that a decrease in NKp46, a representative activating receptor, is common between NK cells in PBMC culture with asbestos and those of mesothelioma patients.
Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.
Review
Rutella et al., Doha, Qatar. In Front Immunol, 2014
NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin-like receptors, NK Group 2 member D (NKG2D), NKG2A/CD94, NKp46, and others, and recognize both foreign and self-antigens expressed by NK-susceptible targets.
The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.
Impact
Di Santo et al., Paris, France. In Immunity, 2014
Intestinal ILC3s expressed CXCR6 and its ablation generated a selective loss of the NKp46(+) ILC3 subset, a depletion of intestinal IL-22, and the inability to control C. rodentium infection.
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Impact
Diefenbach et al., Mainz, Germany. In Cell, 2014
Instead, the CHILP gave rise to a peculiar NKp46(+) IL-7Rα(+) ILC lineage that required T-bet for specification and was distinct of cNK cells or other ILC lineages.
Dimerization of NKp46 receptor is essential for NKp46-mediated lysis: characterization of the dimerization site by epitope mapping.
GeneRIF
Porgador et al., Beersheba, Israel. In J Immunol, 2012
We suggest that NKp46 dimerization contributes to NKp46-mediated lysis by NK cells.
CD158k/KIR3DL2 and NKp46 are frequently expressed in transformed mycosis fungoides.
GeneRIF
Bensussan et al., In Exp Dermatol, 2012
expressed in all investigated cases of transformed mycosis fungoides
Recognition and prevention of tumor metastasis by the NK receptor NKp46/NCR1.
GeneRIF
Mandelboim et al., Jerusalem, Israel. In J Immunol, 2012
NKp46/NCR1 plays an important role in controlling neoplasm metastasis
Changes in natural killer cell subsets in pediatric liver transplant recipients.
GeneRIF
Krams et al., Stanford, United States. In Pediatr Transplant, 2012
NKp46 levels remain stable on the natural killer cells that persist at one week post-liver transplant in pediatric patients.
Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease.
GeneRIF
Mandelboim et al., Jerusalem, Israel. In Plos Pathog, 2011
NCR1 and NKp46 directly recognize a periodontal pathogen.
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