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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Natural cytotoxicity triggering receptor 2

NKp44
Top mentioned proteins: NKp46, NKp30, NKG2D, CAN, CD56
Papers on NKp44
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
New
Brusselle et al., Gent, Belgium. In Plos One, Dec 2015
Based on the presence of NKp44, ILC3 were further subdivided in natural cytotoxicity receptor (NCR)+ and NCR- ILC3.
[Study of NK cells dysfunction in multiple myeloma patients].
New
Lu et al., Changzhou, China. In Zhonghua Xue Ye Xue Za Zhi, Dec 2015
METHODS: The expression of inhibitory receptors(CD158a and CD158b)and activating receptors NKG2D and NCRs(NKp30, NKp44 and NKp46)on CD3-CD56+NK cell of 13 MM patients and 30 healthy controls were analyzed by flow cytometry.
A novel method to expand large numbers of CD56(+) natural killer cells from a minute fraction of selectively accessed cryopreserved cord blood for immunotherapy after transplantation.
New
Childs et al., Columbus, United States. In Cytotherapy, Nov 2015
These cells expressed high levels of CD161, LFA-1, CD69, NKG2D, NKp30, NKp44, NKp80 and NKp46.
Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis.
New
Giacomini et al., Roma, Italy. In Oncotarget, Nov 2015
Interestingly, suboptimal cell death-inducing concentrations (1.5 μM αTOS/20 μM AA/0.2 μM VK3) effectively up-regulated activating Natural Killer (NK) cell ligands, including MICA (the stress-signaling ligand of the NKG2D receptor), and/or the ligands of at least one of the natural cytotoxicity receptors (NKp30, NKp44 and NKp46) in 5/6 melanoma cell lines.
NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures.
Ferlazzo et al., Genova, Italy. In Nat Commun, 2014
Tumour NCR(+)ILC3 may interact with both lung tumour cells and tumour-associated fibroblasts, resulting in the release of cytokines primarily on engagement of the NKp44-activating receptor.
Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infection.
Tripathy et al., Pune, India. In Front Microbiol, 2014
The percentages of NKp44(+)CD3(-)CD56(+) cells were high in both patient groups, whereas the percentages of NKp44(+)CD3(+)CD56(+) cells were higher in the acute group than in convalescent and control groups.
NKp44 and Natural Cytotoxicity Receptors as Damage-Associated Molecular Pattern Recognition Receptors.
Review
Mathew et al., Fort Worth, United States. In Front Immunol, 2014
Among the activating receptors is a small class of specialized receptors termed the natural cytotoxicity receptors (NCRs) comprised of NKp30, NKp46, and NKp44.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Multhoff et al., München, Germany. In Front Immunol, 2014
Following activation, NK cells show an up-regulated expression of activatory C-type lectin receptors, such as CD94/NKG2C, NKG2D, and natural cytotoxicity receptors (NCRs; NKp44, NKp46, and NKp30) and thereby gain the capacity to kill mHsp70-positive tumor cells.
Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes.
Jabrane-Ferrat et al., Toulouse, France. In Nat Commun, 2014
The natural cytotoxicity receptors NKp46/NCR1, NKp44/NCR2 and NKp30/NCR3 are critical for natural killer (NK) cell functions.
Natural cytotoxicity receptors and their ligands.
Review
Vivier et al., Marseille, France. In Immunol Cell Biol, 2014
NK cells and subsets of ILCs express the natural cytotoxicity receptors (NCRs) NKp46, NKp44 and NKp30 at their surface.
The role of natural cytotoxicity receptors in various pathologies: emphasis on type I diabetes.
Review
Mandelboim et al., Jerusalem, Israel. In Front Immunol, 2013
A prominent group of activating NK receptors is the natural cytotoxicity receptors (NCRs), which includes NKp30, NKp44, and NKp46.
RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44.
Impact
Romagnani et al., Berlin, Germany. In Immunity, 2013
Here we showed that RORγt⁺ ILCs can directly sense the environment by the engagement of the activating receptor NKp44.
Regulation of self-ligands for activating natural killer cell receptors.
Review
Gasser et al., Singapore, Singapore. In Ann Med, 2013
We review numerous pathways that have been implicated in the regulation of self-ligands for activating receptors, including NKG2D, DNAM-1, LFA-1, NKp30, NKp44, NKp46, NKp65, and NKp80 found on NK cells and some T cells.
[Roles of RORγt+ innate lymphoid cells in mucosal tissues of mouse and human].
Review
Sawa, Tokyo, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2012
Human fetal intestine, tonsil and lympho nodes harbor both NKp44 positive and negative RORγt(+) ILC subsets.
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.
GeneRIF
Ganem et al., San Francisco, United States. In J Virol, 2012
These data show that the Kaposi's sarcoma-associated herpesvirus ORF54 product downregulates the NKp44 ligand and that the NKp44-NKp44 ligand signaling pathway contributes to antiviral immunity.
Expression of natural killer cell activating receptors in patients with chronic lymphocytic leukaemia.
GeneRIF
Sébahoun et al., Marseille, France. In Immunology, 2012
a precise analysis of clinical data showed a correlation between decreased NCR expression and poor prognosis factors such as low haemoglobin level, high (>30x10(9) per litre) lymphocyte count or elevated C-reactive protein
Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44.
GeneRIF
Porgador et al., Beersheba, Israel. In J Immunol, 2012
We demonstrate that PCNA promotes cancer survival by immune evasion through inhibition of NKp44-mediated NK cell attack.
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.
GeneRIF
Hibi et al., Tokyo, Japan. In Gastroenterology, 2010
The balance of NKp44(+)/NKp46(+) NK cells is disrupted in intestinal mucosa of patients with Crohn's disease.
The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production.
GeneRIF
Ferlazzo et al., Messina, Italy. In Plos One, 2009
Data show that pDCs isolated from peripheral blood of systemic lupus erithematosus (SLE) patients express lower levels of LAIR-1 while displaying slight but consistent expression of NKp44.
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Review
Impact
Moretta et al., Genova, Italy. In Annu Rev Immunol, 2000
Three novel, NK-specific, triggering surface molecules (NKp46, NKp30, and NKp44) have been identified.
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