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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Natural cytotoxicity triggering receptor 3

NKp30, MALS, 1C7
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: NKp46, NKG2D, NKp44, CAN, CD16
Papers on NKp30
Development of monoclonal antibodies against polar filaments and spore valves of Myxobolus honghuensis (Myxosporea: Bivalvulida).
New
Zhai et al., Wuhan, China. In Dis Aquat Organ, Feb 2016
Two monoclonal antibodies (MAbs 1C7 and 3B7) were prepared by immunizing mice with soluble protein from sonicated M. honghuensis spores.
Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
New
Krengel et al., Oslo, Norway. In J Mol Biol, Feb 2016
Here, we show how MtDS serves as an allosteric platform for feedback regulation of both enzymes, using X-ray crystallography, SAXS, SEC, and MALS.
Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation.
New
Ohdan et al., Hiroshima, Japan. In Transplantation, Jan 2016
In the assays using a Huh7-HCV replicon system, anti-HCV activity was induced via recognition of the NK cell receptors, including NKp46, NKp30, and NKG2D, which was demonstrated by the use of monoclonal antibodies that neutralized neutralizing molecules.
The molecular basis of TnrA control by glutamine synthetase in Bacillus subtilis.
New
Forchhammer et al., Tübingen, Germany. In J Biol Chem, Jan 2016
According to size-exclusion and multi-angle light scattering analysis (MALS), the dodecameric GS can bind three TnrA dimers.
Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.
Review
New
Flajnik et al., Baltimore, United States. In Immunol Rev, Sep 2015
Regarding the major histocompatibility complex (MHC) and coevolution, three striking cases have been revealed in cold-blooded vertebrates: lineages of class Ia antigen-processing and -presenting genes, evolutionary conservation of NKT-class Ib recognition, and the ancient emergence of the natural cytotoxicity receptor NKp30 and its ligand B7H6.
Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes.
Jabrane-Ferrat et al., Toulouse, France. In Nat Commun, 2014
The natural cytotoxicity receptors NKp46/NCR1, NKp44/NCR2 and NKp30/NCR3 are critical for natural killer (NK) cell functions.
NKp44 and Natural Cytotoxicity Receptors as Damage-Associated Molecular Pattern Recognition Receptors.
Review
Mathew et al., Fort Worth, United States. In Front Immunol, 2014
Among the activating receptors is a small class of specialized receptors termed the natural cytotoxicity receptors (NCRs) comprised of NKp30, NKp46, and NKp44.
Baseline and Dynamic Expression of Activating NK Cell Receptors in the Control of Chronic Viral Infections: The Paradigm of HIV-1 and HCV.
Review
De Maria et al., Genova, Italy. In Front Immunol, 2013
Studies on patients with viral infection (HIV and HCV) and specific diverging clinical courses confirm that inter-individual differences may exist in baseline expression of natural cytotoxicity receptors (NKp46 and NKp30).
Structural basis for recognition of cellular and viral ligands by NK cell receptors.
Review
Mariuzza et al., Rockville, United States. In Front Immunol, 2013
A growing number of NK receptor-ligand interaction pairs involving non-MHC molecules have also been identified, including NKp30-B7-H6, killer cell lectin-like receptor G1-cadherin, and NKp80-AICL.
The role of natural cytotoxicity receptors in various pathologies: emphasis on type I diabetes.
Review
Mandelboim et al., Jerusalem, Israel. In Front Immunol, 2013
A prominent group of activating NK receptors is the natural cytotoxicity receptors (NCRs), which includes NKp30, NKp44, and NKp46.
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.
Impact
Chiocca et al., Columbus, United States. In Nat Med, 2012
This enhanced killing depended on the NK cell natural cytotoxicity receptors (NCRs) NKp30 and NKp46, whose ligands are upregulated in oHSV-infected glioblastoma cells.
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
GeneRIF
Koch et al., Frankfurt am Main, Germany. In J Biol Chem, 2012
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.
GeneRIF
Sentman et al., United States. In J Immunol, 2012
NKp30 chimeric antigen receptor-expressing T cells produce interferon (IFN)-gamma and kill B7-H6 ligand-expressing tumor cells in vivo.
Changes in natural killer cell subsets in pediatric liver transplant recipients.
GeneRIF
Krams et al., Stanford, United States. In Pediatr Transplant, 2012
NKp30 expression is significantly increased on the natural killer cells that persist at one week post-liver transplant in pediatric patients.
Expression of natural killer cell activating receptors in patients with chronic lymphocytic leukaemia.
GeneRIF
Sébahoun et al., Marseille, France. In Immunology, 2012
a precise analysis of clinical data showed a correlation between decreased NCR expression and poor prognosis factors such as low haemoglobin level, high (>30x10(9) per litre) lymphocyte count or elevated C-reactive protein
Important role for NKp30 in synapse formation and activation of NK cells.
GeneRIF
Sun et al., Hefei, China. In Immunol Invest, 2011
NKp30 is a triggering receptor downstream of adhesion and plays an important role in NK cell activation, degranulation and cytotoxicity.
Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.
Impact
GeneRIF
Zitvogel et al., Villejuif, France. In Nat Med, 2011
alternatively spliced isoforms affect the prognosis of gastrointestinal stromal tumors
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.
Impact
GeneRIF
Engert et al., Köln, Germany. In Immunity, 2007
HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model.
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
Impact
Mandelboim et al., Jerusalem, Israel. In Nat Immunol, 2005
Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30.
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
Review
Impact
Moretta et al., Genova, Italy. In Annu Rev Immunol, 2000
Three novel, NK-specific, triggering surface molecules (NKp46, NKp30, and NKp44) have been identified.
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