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Naked cuticle homolog 2

NKD2, Naked2, naked cuticle 2
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003] (from NCBI)
Top mentioned proteins: NKD1, PKI, CAN, Frizzled, V1a
Papers on NKD2
Up-Regulation of Corticocerebral NKD2 in Lipopolysaccharide-Induced Neuroinflammation.
Zhang et al., Nantong, China. In Cell Mol Neurobiol, Jan 2016
Naked2 (NKD2), one member of Naked family, has been shown to negatively regulate Wnt/β-catenin signaling pathway.
Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer.
Guo et al., Beijing, China. In Oncotarget, Nov 2015
Naked cuticle homolog2 (NKD2) is located in chromosome 5p15.3,
NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.
Yustein et al., Houston, United States. In Oncogene, Oct 2015
Microarray analysis of both localized tumors and metastatic tumors identified the downregulation of the naked cuticle homolog 2 (NKD2) gene, a negative regulator of Wnt signaling.
Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth.
Guo et al., Beijing, China. In Oncotarget, Oct 2015
Naked cuticle homolog 2 (NKD2) has been reported to antagonize Wnt signaling in zebrafish, mouse and mammals.
The naked endosperm genes encode duplicate INDETERMINATE domain transcription factors required for maize endosperm cell patterning and differentiation.
Becraft et al., Ames, United States. In Plant Physiol, Feb 2015
The nkd1 and nkd2 genes encode the INDETERMINATE1 domain (IDD) containing transcription factors ZmIDDveg9 and ZmIDD9 on chromosomes 2 and 10, respectively.
A Fast Incremental Gaussian Mixture Model.
Engel et al., Porto Alegre, Brazil. In Plos One, 2014
In this work, we manage to reduce this complexity to O(NKD2) by deriving formulas for working directly with precision matrices instead of covariance matrices.
A monoclonal antibody produced against Naked2.
Yan et al., Xiamen, China. In Monoclon Antib Immunodiagn Immunother, 2013
Naked2 (NKD2) is a member of the Naked family and negatively regulates canonical Wnt signaling.
Chiari malformation type I: a case-control association study of 58 developmental genes.
Macaya et al., Barcelona, Spain. In Plos One, 2012
Single-marker analysis identified nominal associations with 18 SNPs in 14 genes (CDX1, FLT1, RARG, NKD2, MSGN1, RBPJ1, FGFR1, RDH10, NOG, RARA, LFNG, KDR, ALDH1A2, BMPR1A) considering the whole CMI sample.
The noncoding RNA expression profile and the effect of lncRNA AK126698 on cisplatin resistance in non-small-cell lung cancer cell.
Wang et al., Beijing, China. In Plos One, 2012
Expression of NKD2 and β-catenin was assessed by realtime RT-PCR and western blot analysis.
Novel functional proteins interact with midkine in hepatic cancer cells.
Zheng et al., Hangzhou, China. In Hepatobiliary Pancreat Dis Int, 2012
RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-alpha), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-beta binding protein 3, latent active TGF-beta binding protein 4, and phospholipid scramblase 1.
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane.
Coffey et al., Xiamen, China. In J Biol Chem, 2010
NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.
Convergence between Wnt-β-catenin and EGFR signaling in cancer.
Li et al., Xiamen, China. In Mol Cancer, 2009
NKD2, a Wnt antagonist by interacting with Dishevelled, also escorts TGFα-containing exocytic vesicles to the basolateral membrane of polarized epithelial cells.
EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.
Coffey et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2008
identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling.
Solnica-Krezel et al., Nashville, United States. In Dev Biol, 2007
data indicate that zebrafish Nkd1 and Nkd2 function to limit both canonical and non-canonical Wnt signaling
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.
Coffey et al., Nashville, United States. In Mol Biol Cell, 2007
Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.
WNT signaling pathway and stem cell signaling network.
Katoh et al., Japan. In Clin Cancer Res, 2007
Microtubule affinity-regulating kinase (PAR-1) family kinases, casein kinase I epsilon (CKI epsilon), and FRAT are positive regulators of the canonical WNT pathway, whereas APC, AXIN1, AXIN2, CKI alpha, NKD1, NKD2, beta TRCP1, beta TRCP2, ANKRD6, Nemo-like kinase (NLK), and peroxisome proliferator-activated receptor gamma (PPAR gamma) are negative regulators.
Mouse naked cuticle 2 (mNkd2) as a direct transcriptional target of Hoxc8 in vivo.
Ruddle et al., New Haven, United States. In J Exp Zool A Ecol Genet Physiol, 2007
Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 in vivo.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT/PCP signaling pathway and human cancer (review).
Katoh, Tokyo, Japan. In Oncol Rep, 2005
ANKRD6, NKD1 and NKD2 induce class switch from the WNT/GSK3beta signaling pathway to the WNT/PCP signaling pathway.
WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
APC, AXIN, NKD1, NKD2, and Strabismus (STB1, STB2) are negative regulators of WNT - beta-catenin pathway.
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