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Naked cuticle homolog 1

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003] (from NCBI)
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Top mentioned proteins: NKD2, PKI, CAN, Wnt3a, V1a
Papers on NKD1
FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1.
Duncan et al., Milwaukee, United States. In Genes Dev, Jan 2016
One of these immediate early genes encodes naked cuticle homolog 1 (NKD1), which is a repressor of canonical WNT (wingless-type MMTV integration site) signaling.
Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer.
Guo et al., Beijing, China. In Oncotarget, Nov 2015
Naked cuticle homolog2 (NKD2) is located in chromosome 5p15.3,
Paired-like Homeodomain Transcription factor 2 expression by breast cancer bone marrow disseminated tumor cells is associated with early recurrent disease development.
Aft et al., Saint Louis, United States. In Breast Cancer Res Treat, Oct 2015
Three genes-NKD1, LEF1, and DKK4-were significantly downregulated in response to PITX2 suppression.
Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth.
Guo et al., Beijing, China. In Oncotarget, Oct 2015
Naked cuticle homolog 2 (NKD2) has been reported to antagonize Wnt signaling in zebrafish, mouse and mammals.
Wnt ligand-dependent activation of the negative feedback regulator Nkd1.
Van Raay et al., Guelph, Canada. In Mol Biol Cell, Jul 2015
There are numerous negative feedback regulators of Wnt signaling, but two stand out as constitutive and obligate Wnt-induced regulators: Axin2 and Nkd1.
Expression pattern and clinicopathologic significance of NKD1 in human primary hepatocellular carcinoma.
Wang et al., China. In Apmis, Apr 2015
It has been reported that NKD1 was an antagonist of the canonical Wnt/β-catenin pathway.
The naked endosperm genes encode duplicate INDETERMINATE domain transcription factors required for maize endosperm cell patterning and differentiation.
Becraft et al., Ames, United States. In Plant Physiol, Feb 2015
Whereas normal maize (Zea mays [Zm]) has a single aleurone layer, naked endosperm (nkd) mutants produce multiple outer cell layers of partially differentiated cells that show sporadic expression of aleurone identity markers such as a viviparous1 promoter-β-glucuronidase transgene.
Epigenetic changes and functional study of HOXA11 in human gastric cancer.
Guo et al., Beijing, China. In Epigenomics, 2014
HOXA11 was found to inhibit Wnt signaling by upregulating NKD1 expression.
NKD1 down-regulation is associated with poor prognosis in breast invasive ductal carcinoma.
Kong et al., Qingdao, China. In Int J Clin Exp Pathol, 2014
As a negative modulator of the canonical Wnt signaling pathway, Naked1 (NKD1) is widely expressed in many normal tissues.
Wnt signaling pathway in non-small cell lung cancer.
Stewart, Ottawa, Canada. In J Natl Cancer Inst, 2014
Downregulation of Wnt inhibitors (eg, by hypermethylation) is common in NSCLC tumor cell lines and resected samples; may be associated with high stage, dedifferentiation, and poor prognosis; and has been reported for AXIN, sFRPs 1-5, WIF-1, Dkk-1, Dkk-3, HDPR1, RUNX3, APC, CDX2, DACT2, TMEM88, Chibby, NKD1, EMX2, ING4, and miR-487b.
Inborn errors of the development of human natural killer cells.
Casanova et al., Paris, France. In Curr Opin Allergy Clin Immunol, 2013
Rare patients with mini chromosomal maintenance 4 deficiency display an apparently selective NKD associated with viral infections, but they also display various nonhematopoietic phenotypes, including adrenal insufficiency and growth retardation.
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning.
Slusarski et al., Iowa City, United States. In Dev Biol, 2011
Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression.
Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin.
Coffey et al., Nashville, United States. In Plos One, 2010
Data demonstrate that Nkd1 binds to beta-catenin and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane.
Down-regulation of NKD1 increases the invasive potential of non-small-cell lung cancer and correlates with a poor prognosis.
Wang et al., Shenyang, China. In Bmc Cancer, 2010
Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC
Tachykinin-related peptides and their receptors in invertebrates: a current view.
Vanden Broeck et al., Leuven, Belgium. In Peptides, 2010
NKD (neurokinin receptor from Drosophila), DTKR (Drosophila tachykinin receptor) and STKR (tachykinin-related peptide receptor from the stable fly, Stomoxys calcitrans).
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling.
Liu et al., New Orleans, United States. In Plos One, 2008
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling
Regulation of the feedback antagonist naked cuticle by Wingless signaling.
Cadigan et al., Ann Arbor, United States. In Dev Biol, 2008
Wingless signalling regulates the feedback antagonist naked cuticle through a series of Wingless response elements.
WNT signaling pathway and stem cell signaling network.
Katoh et al., Japan. In Clin Cancer Res, 2007
Microtubule affinity-regulating kinase (PAR-1) family kinases, casein kinase I epsilon (CKI epsilon), and FRAT are positive regulators of the canonical WNT pathway, whereas APC, AXIN1, AXIN2, CKI alpha, NKD1, NKD2, beta TRCP1, beta TRCP2, ANKRD6, Nemo-like kinase (NLK), and peroxisome proliferator-activated receptor gamma (PPAR gamma) are negative regulators.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
naked cuticle encodes an inducible antagonist of Wnt signalling.
Scott et al., Stanford, United States. In Nature, 2000
Here we show that naked cuticle (nkd), a Drosophila segment-polarity gene, encodes an inducible antagonist for the Wnt signal Wingless (Wg).
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