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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interleukin 32

NK4, IL-32, Taif, Interleukin-32
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: hepatocyte growth factor, V1a, CAN, Interleukin-6, IL-1beta
Papers using NK4 antibodies
Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism
Supplier
Hong J T et al., In Oncogene, 1995
... IL-32 gene expression in various tissues of transgenic mice, total RNAs were ...
Papers on NK4
Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia.
New
Watson et al., In Emerg Infect Dis, Jan 2016
During September 2014-January 2015, an outbreak of 38 cases of MERS was reported from 4 healthcare facilities in Taif, Saudi Arabia; 21 of the 38 case-patients died.
Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines.
New
Joosten et al., Nijmegen, Netherlands. In Carcinogenesis, Jan 2016
Some isoforms of interleukin 32 (IL-32) are reported to be more potent in inducing inflammation, however the role in cell death remains to be investigated.
Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.
New
Krueger et al., New York City, United States. In Exp Dermatol, Jan 2016
qRT-PCR showed in pre-treatment lesional scalp (compared to NL) significant increases (p<0.05) in expression of inflammatory markers (IL-2, IL-2RA, JAK3, IL-15), Th1 (CXCL10 and CXCL9), Th2 (IL-13, CCL17 and CCL18), IL-12/IL-23p40 and IL-32.
Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice.
New
Hong et al., Ch'ŏngju, South Korea. In Oncotarget, Jan 2016
Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminate, is an inflammatory disease in which myelin in the spinal cord and brain are damaged.
Decreased severity of collagen antibody and lipopolysaccharide-induced arthritis in human IL-32β overexpressed transgenic mice.
New
Hong et al., South Korea. In Oncotarget, Dec 2015
However, the role of IL-32 on inflammatory disease has been doubtful according to diverse conflicting results.
Tripterygium glycosides inhibit inflammatory mediators in the rat synovial RSC-364 cell line stimulated with interleukin-1β.
New
Dai et al., Shenzhen, China. In Biomed Rep, Nov 2015
The expression of IL-32 and matrix metalloproteinases (MMP-1 and MMP-9) was determined using an enzyme-linked immunosorbent assay.
IL-18 Binding Protein Ameliorates Ischemia/Reperfusion-Induced Hepatic Injury in Mice.
New
Giakoustidis et al., Thessaloníki, Greece. In Liver Transpl, Nov 2015
Likewise, blocking of IL-18 ablated the I/R-associated elevation of NF-κB, c-Jun, MPO and IL-32 and the upregulation of neutrophils and T-helper lymphocytes.
Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection.
Review
New
Zhu et al., Wuhan, China. In Viruses, Jun 2015
Since the discovery of IL-32 in 2005, our appreciation for its diverse roles continues to grow.
A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation.
Review
Sheikh et al., Lahore, Pakistan. In Eur J Med Res, 2014
Interleukin-32 (IL-32) is a recently identified cytokine, whose gene is located on human chromosome 16 p13.3,
Cytokine-modulating strategies and newer cytokine targets for arthritis therapy.
Review
Moudgil et al., Baltimore, United States. In Int J Mol Sci, 2014
Furthermore, the relatively newer cytokines such as IL-32, IL-34 and IL-35 are being investigated for their potential role in the pathogenesis and treatment of arthritis.
High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation.
Kim et al., Seoul, South Korea. In Arthritis Res Ther, 2014
RESULTS: The IL-32γ levels were higher in the synovial fluid of AS patients compared with RA or OA patients and the expression of IL-32 was higher in AS synovia than in RA or OA synovia.
Interleukin-32 in inflammatory autoimmune diseases.
Review
Kim, Seoul, South Korea. In Immune Netw, 2014
Interleukin-32 (IL-32) is a cytokine inducing crucial inflammatory cytokines such as tumor necrosis factor-α (TNFα) and IL-6 and its expression is elevated in various inflammatory autoimmune diseases, certain cancers, as well as viral infections.
Cytokine inhibition in the treatment of COPD.
Review
Chung et al., Ferrara, Italy. In Int J Chron Obstruct Pulmon Dis, 2013
Proinflammatory cytokines of potential importance include tumor necrosis factor (TNF)-α, interferon-γ, interleukin (IL)-1β, IL-6, IL-17, IL-18, IL-32, and thymic stromal lymphopoietin (TSLP), and growth factors such as transforming growth factor-β.
Regulation and expression of IL-32 in chronic rhinosinusitis.
GeneRIF
Meyer et al., Zürich, Switzerland. In Allergy, 2012
these data demonstrated a potential role for IL-32 in the pathogenesis of chronic rhinosinusitis
Dysregulation of overexpressed IL-32α in hepatocellular carcinoma suppresses cell growth and induces apoptosis through inactivation of NF-κB and Bcl-2.
GeneRIF
Song et al., Taejŏn, South Korea. In Cancer Lett, 2012
suggest that IL-32alpha is involved in the progression of hepatocellular carcinoma and may be a useful biomarker for diagnosis and therapeutic target of hepatocellular carcinoma
Characterizing antiviral mechanism of interleukin-32 and a circulating soluble isoform in viral infection.
GeneRIF
Kim et al., Seoul, South Korea. In Cytokine, 2012
The present results suggest that IL-32gamma expression and its genetic variation in individual could be an important aspect of viral infections.
NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy.
Impact
Modlin et al., Los Angeles, United States. In Nat Med, 2012
In the human mycobacterial infection leprosy, we found that activation of monocytes via nucleotide-binding oligomerization domain-containing protein 2 (NOD2) by its ligand muramyl dipeptide, as compared to activation via heterodimeric Toll-like receptor 2 and Toll-like receptor 1 (TLR2/1) by triacylated lipopeptide, preferentially induced differentiation into dendritic cells (DCs), which was dependent on a previously unknown interleukin-32 (IL-32)-dependent mechanism.
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.
GeneRIF
Joosten et al., Nijmegen, Netherlands. In J Biol Chem, 2012
IL-32 binds to the extracellular domain of integrins and to intracellular proteins like paxillin and FAK
Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3.
GeneRIF
Hong et al., Ch'ŏngju, South Korea. In Immunology, 2012
It was shown that IL-32 enhanced the cytotoxic effect of natural killer cells on protate cancer cells through activation of DR3 and caspase-3.
Interleukin-32: a cytokine and inducer of TNFalpha.
Impact
Dinarello et al., Denver, United States. In Immunity, 2005
Although IL-32 does not share sequence homology with known cytokine families, IL-32 induces various cytokines, human TNFalpha, and IL-8 in THP-1 monocytic cells as well as mouse TNFalpha and MIP-2 in Raw macrophage cells.
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