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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nitric oxide synthase 3, endothelial cell

Nitric Oxide Synthase, eNOS
enzyme that synthesizes Nitric oxide from L-arginine [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: iNOS, V1a, CAN, cyclooxygenase, HAD
Papers using Nitric Oxide Synthase antibodies
Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance
Wang Dao Wen et al., In Cardiovascular Diabetology, 2010
... AKT, phosphorylated AKT (P-AKT), AMPK, phosphorylated AMPK (P-AMPK), insulin receptor substrate-1 (IRS-1), phosphorylated IRS-1, and eNOS were from Santa Cruz Biotechnology Inc ...
Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease.
Conklin Daniel J. et al., In Environmental Health Perspectives, 2009
... antibodies against VEGFR-2, phosphorylated (phospho)-Akt (Ser473), Akt, phospho-eNOS (phosphorylated endothelial nitric oxide synthase; Ser1177), and eNOS (1:1,000), all from Cell Signaling Technology (Danvers, MA) or ...
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone
Zou Ming-Hui et al., In Journal of Cellular and Molecular Medicine, 2007
... Antibodies against eNOS, phospho-Ser1177 of eNOS and 3-nitrotyrosine-specifc antibody were obtained from Cell Signaling Technology (Danvers, MA, USA) ...
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration
Stetler-Stevenson William George et al., In Laboratory investigation; a journal of technical methods and pathology, 2007
... ), and anti-eNOS antibodies were purchased from Cell Signaling Technology ...
Cyanidin-3-O-β-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages
Galvano Fabio et al., In Toxins, 2007
... Mouse monoclonal eNOS antibody was from Sigma Aldrich, rabbit polyclonal iNOS antibody ...
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Papers on Nitric Oxide Synthase
Antidepressant Effect of Cnestis ferruginea Vahl ex DC (Connaraceae): Involvement of Cholinergic, Monoaminergic and L-arginine-nitric Oxide Pathways.
Adeyemi et al., Lagos, Nigeria. In Drug Res (stuttg), Feb 2016
Methods: Male albino mice were pretreated with monoaminergic or cholinergic receptor antagonists, L-arginine or N(G)-nitro-L-arginine (nitric oxide synthase inhibitor) (at doses reported to block the in vivo effect of the agonists), 15 min before oral administration of CF (100 mg/kg), 1 h later, the forced swim test (FST) in mice was carried out.
Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3.
Bernlohr et al., Minneapolis, United States. In Mol Endocrinol, Feb 2016
When compared to controls, silencing of SIRT3 in Raw246.7 macrophages leads to increased expression of inflammatory cytokines, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (Cox2).
Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo.
Takeuchi et al., Ōsaka, Japan. In Neurogastroenterol Motil, Feb 2016
When an inhibitor of nitric oxide synthase was added following the EFS, neither NCX1 HET nor NCX2 HET exhibited transient relaxation, similar to WT.
Compromised redox homeostasis, altered nitroso-redox balance and therapeutic possibilities in atrial fibrillation.
Casadei et al., Oxford, United Kingdom. In Cardiovasc Res, Feb 2016
Recent studies demonstrate spatiotemporal changes in reactive oxygen species production shortly after the induction of AF in animal models with an uncoupling of nitric oxide synthase activity ensuing in the presence of long-standing persistent AF, ultimately leading to a major shift in nitroso-redox balance.
Challenges in developing drugs for primary headache.
Ashina et al., Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
Glutamate receptor antagonism whilst efficacious has central side effects and some approaches such as nitric oxide synthase inhibition, substance P antagonism and cortical spreading depression blockade, despite having promising effects in basic pain models, have not delivered efficacy in the clinic.
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Froehner et al., Sydney, Australia. In Physiol Rev, Jan 2016
In this review, we will consider the various proteins whose expression and function is changed in muscular dystrophies, focusing on Ca(2+)-permeable channels, nitric oxide synthase, NADPH oxidase, and caveolins.
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability.
de Diego-Otero et al., Málaga, Spain. In Oxid Med Cell Longev, Dec 2015
Besides that, nuclear factor NF-κB-p65 and inducible nitric oxide synthase appeared significantly increased in the Fmr1-knockout mice.
Noise-Induced Neural Degeneration and Therapeutic Effect of Antioxidant Drugs.
Choi et al., Kyŏngsan, South Korea. In J Audiol Otol, Dec 2015
Oxidative stress has been identified by a variety of biomarkers to label free radical activity which include four-hydroxy-2-nonenal, nitrotyrosine, and malondialdehyde, and inducible nitric oxide synthase, cytochrome-C, and cascade-3, 8, 9. Furthermore, oxidative stress is contributing to the necrotic and apoptotic cell deaths in the cochlea.
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.
Iwakiri, New Haven, United States. In Clin Mol Hepatol, Dec 2015
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions.
Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant and Anti-Inflammatory Properties of a Stilbenoid-Rich Root Extract of Vitis vinifera.
Rimbach et al., Kiel, Germany. In Oxid Med Cell Longev, Dec 2015
Furthermore, the root extract could induce the antiatherogenic hepatic enzyme paraoxonase 1 and downregulate proinflammatory gene expression (interleukin 1β, inducible nitric oxide synthase) in macrophages.
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.
Hotamisligil et al., Boston, United States. In Science, Aug 2015
Here, we show that, in the setting of obesity, inflammatory input through increased inducible nitric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1α, which leads to a progressive decline in hepatic IRE1α-mediated XBP1 splicing activity in both genetic (ob/ob) and dietary (high-fat diet-induced) models of obesity.
Evaluation of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man.
Casadei et al., Maastricht, Netherlands. In Lancet, Mar 2015
We aimed to evaluate the role of miR-31-dependent reduction in dystrophin and neuronal nitric oxide synthase (nNOS, also known as NOS1) on atrial electrical properties and atrial fibrillation inducibility.
Role of vitamin D in endothelial function and endothelial repair in clinically stable systemic lupus erythematosus.
Bruce et al., Manchester, United Kingdom. In Lancet, Mar 2015
Endothelial nitric oxide synthase (eNOS) expression was studied in human aortic endothelial cells treated with tumour necrosis factor α (TNFα) and MAC-conditioned media.
Molecular mechanisms of myocardial nitroso-redox imbalance during on-pump cardiac surgery.
Casadei et al., Oxford, United Kingdom. In Lancet, Mar 2015
In isolated rat hearts subjected to an ischaemia-reperfusion protocol, left ventricular dysfunction was associated with uncoupling of endothelial nitric oxide synthase (NOS) activity secondary to oxidation of the NOS cofactor, tetrahydrobiopterin (BH4).
Pressor Response to Noradrenaline in the Setting of Septic Shock: Anything New under the Sun-Dexmedetomidine, Clonidine? A Minireview.
Quintin et al., Villeurbanne, France. In Biomed Res Int, 2014
Indeed, steroids, nitric oxide synthase inhibitors, or donors have not achieved overwhelming acceptance in the setting of septic shock.
Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice.
Katusic et al., Rochester, United States. In J Neurochem, 2012
In the cerebral microvessels of hph-1(+/-) and hph-1(-/-) mice, increased superoxide anion production was inhibited by supplementation of BH(4) or NOS inhibitor- L- N(G) -nitro arginine-methyl ester, indicative of eNOS uncoupling.
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling.
Kass et al., Baltimore, United States. In Circulation, 2012
PDE5(+) mice developed worse dysfunction and hypertrophy and enhanced natriuretic peptide stimulation, whereas Nos3(-) mice were protected.
Src kinase-mediates androgen receptor-dependent non-genomic activation of signaling cascade leading to endothelial nitric oxide synthase.
Okabe et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
these data indicate that testosterone induces rapid assembly of a membrane signaling complex among AR, caveolin-1 and c-Src, which then facilitates activation of the c-Src/ PI3-kinase/Akt cascade, resulting in activation of eNOS.
Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells.
Eichler et al., Tampa, United States. In J Biol Chem, 2012
phosphorylation of argininosuccinate synthase at Ser-328 is regulated in accordance with the calcium-dependent regulation of eNOS under conditions that promote nitric oxide production
Endothelial nitric oxide synthase (G894T) gene polymorphism in a random sample of the Egyptian population: comparison with myocardial infarction patients.
Abou-Aisha et al., Cairo, Egypt. In Genet Test Mol Biomarkers, 2012
the lack of association between eNOS genotypes and mean serum levels of NO, as well as the incidence of AMI.
More papers using Nitric Oxide Synthase antibodies
Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity.
Gaetano Carlo, In PLoS ONE, 2004
... antibodies for PI3K p85, Akt, phospho-Akt (Ser 473), ERK1/2, phospho-ERK1/2 (Thr 202/Tyr 204), eNOS, and phospho-eNOS (Ser 1177) were purchased from Cell Signaling (Danvers, MA, USA) ...
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.
Xu Aimin, In PLoS ONE, 2003
... Antibodies against phospho-ACC (Ser79), phospho-AMPK (Thr172), AMPK, phospho-LKB1 (Ser428), LKB1, and phospho-eNOS (Ser1177) were purchased from Cell Signaling (Beverly, MA) ...
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase
Sessa William C. et al., In The Journal of Cell Biology, 2001
... Mouse monoclonal antibodies against caveolin-1, GM 130, and eNOS were provided by BD Biosciences.
Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaque
Fleming Ingrid et al., In The Journal of Experimental Medicine, 2000
... The mono-/polyclonal eNOS antibodies were from Santa Cruz Biotechnology, Inc.; the specific phospho-Tyr657 ...
Statistical analyses in the physiology of exercise and kinanthropometry
Wood Matthew JA et al., In Molecular Therapy. Nucleic Acids, 2000
... Neuronal nitric oxide synthase staining was performed using a goat anti-rabbit antibody (Abcam).
Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice
Sessa William C. et al., In The Journal of Experimental Medicine, 2000
... Functional expression of endothelial nitric oxide synthase fused to green fluorescent protein in transgenic mice ...
PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease.
Huang Yu, In PLoS ONE, 1998
... Antibodies against phospho-acetyl-CoA carboxylase (ACC) (Ser79), phospho-AMPK (Thr172), AMPK, and phospho-eNOS (Ser1177) were purchased from Cell Signaling Inc ...
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.
Qin Gangjian, In PLoS ONE, 1996
... Anti-p-AMPK-Thr172, anti-p-eNOS-Ser-1177, anti-AMPK, and anti-eNOS antibodies were from Cell Signaling Technology (Danvers, MA) ...
Glioma invasion in the central nervous system
Chopp Michael et al., In Journal of Experimental & Clinical Cancer Research : CR, 1995
... Antibodies for ERK1, phospho-ERK1, AKT, phospho-AKT (ser473), phosphor-GSK3β (ser9) and phosphor-eNOS (ser1177) were obtained from Cell Signaling Technology (Beverly, MA) ...
KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
Jain Mukesh K. et al., In The Journal of Experimental Medicine, 1995
... p65, IκB-α, phospho–IκB-α, and α-HA were purchased from Santa Cruz Biotechnology, Inc., p300 antibody (Labvision), eNOS antibody (BD Biosciences), anti–E-selectin mAb is clone ...
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice
Wojnowski Leszek et al., In Naunyn-Schmiedeberg's Archives of Pharmacology, 1995
... eNOS transgenic (eNOS-TG) mice overexpressing eNOS ...
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