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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nucleolar complex associated 2 homolog

Nir, nitrite reductase, Nir1, NIRI
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, STEP
Papers on Nir
Anaerobic Growth of Haloarchaeon Haloferax volcanii by Denitrification Is Controlled by the Transcription Regulator NarO.
New
Fujiwara et al., Shizuoka, Japan. In J Bacteriol, Feb 2016
Transcription of the genes encoding the denitrifying enzymes nitrate reductase and nitrite reductase was activated under an anaerobic condition.
Redox-coupled structural changes in nitrite reductase revealed by serial femtosecond and microfocus crystallography.
New
Mizohata et al., Suita, Japan. In J Biochem, Feb 2016
Copper nitrite reductase (CuNiR), which converts nitrite to nitric oxide in denitrification, has been extensively studied by synchrotron radiation crystallography (SRX).
Carbon amendment and soil depth affect the distribution and abundance of denitrifiers in agricultural soils.
New
O'Flaherty et al., Galway, Ireland. In Environ Sci Pollut Res Int, Feb 2016
UNASSIGNED: The nitrite reductase (nirS and nirK) and nitrous oxide reductase-encoding (nosZ) genes of denitrifying populations present in an agricultural grassland soil were quantified using real-time polymerase chain reaction (PCR) assays.
Hypoxemia, oxygen content, and the regulation of cerebral blood flow.
Review
New
Ainslie et al., Colombia. In Am J Physiol Regul Integr Comp Physiol, Jan 2016
We surmise that; 1) during hypoxemic hypoxia in healthy humans (e.g., conditions of acute and chronic exposure to normobaric and hypobaric hypoxia), elevations in CBF compensate for reductions in CaO2 and thus maintain cerebral O2 delivery; 2) evidence from studies implementing iso- and hyper-volumic hemodilution, anemia, and polycythemia, indicate that CaO2 has an independent influence on CBF; however, the increase in CBF does not fully compensate for the lower CaO2 during hemodilution, and delivery is reduced; and 3) the mechanisms underpinning CBF regulation during changes in O2 content are multifactorial, involving deoxyhemoglobin-mediated release of nitric oxide metabolites and ATP, deoxyhemoglobin nitrite reductase activity, and the downstream interplay of several vasoactive factors including adenosine and epoxyeicosatrienoic acids.
Nitrous oxide emission by the non-denitrifying, nitrate ammonifier Bacillus licheniformis.
New
Heylen et al., Gent, Belgium. In Bmc Genomics, Dec 2015
Genome analyses confirmed the lack of a nitrite reductase to nitric oxide, the key enzyme of denitrification.
Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation.
New
Cooper et al., Ningbo, China. In Adv Exp Med Biol, Dec 2015
We therefore modified the model such that NO generation was via the nitrite reductase activity of deoxyhemoglobin instead of NOS, whilst keeping the metabolism of NO by CCO the same.
Synthetic heme/copper assemblies: toward an understanding of cytochrome c oxidase interactions with dioxygen and nitrogen oxides.
New
Impact
Karlin et al., Baltimore, United States. In Acc Chem Res, Sep 2015
In the nitrite reductase chemistry, the cupric center serves as a Lewis acid, while the heme is the redox active center providing the electron.
"Repurposing" of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension.
Review
New
Ahluwalia et al., London, United Kingdom. In Antioxid Redox Signal, Sep 2015
One particular nitrite reductase that has been shown to operate under a wide range of environmental conditions is the enzyme xanthine oxidoreductase (XOR).
Dispelling dogma and misconceptions regarding the most pharmacologically targetable source of reactive species in inflammatory disease, xanthine oxidoreductase.
Review
New
Kelley, Pittsburgh, United States. In Arch Toxicol, Aug 2015
This is exemplified by recent reports: (1) identifying XOR as a nitrite reductase and thus a source of beneficial nitric oxide ((•)NO) under in vivo conditions similar to those where XOR inhibition has been assumed an optimal treatment choice, (2) describing XOR-derived uric acid (UA) as a critical pro-inflammatory mediator in vascular and metabolic disease and (3) ascribing an antioxidant/protective role for XOR-derived UA.
Sub-atomic resolution X-ray crystallography and neutron crystallography: promise, challenges and potential.
Review
New
Antonyuk et al., Grenoble, France. In Iucrj, Aug 2015
New results from two metalloproteins, copper nitrite reductase and cytochrome c', are also included, which illustrate the type of information that can be obtained from sub-atomic-resolution (∼0.8 Å) X-ray structures, while also highlighting the need for complementary neutron studies that can provide details of H atoms not provided by X-ray crystallography.
[THE ROLE OF HEME-CONTAINING GLOBINS IN HYPOXIC NO-SIGNALING OF VERTEBRATE CELLS].
Review
Krasovskaya et al., In Tsitologiia, 2014
The last way is realized mostly at hypoxic state of organisms and heme-containing globins of vertebrates (hemoglobin, myoglobin, cytoglobin, neuroglobin) mediate the transformation of NO2 into NO by means of their nitrite reductase activities.
Structures of protein-protein complexes involved in electron transfer.
Impact
Hasnain et al., Liverpool, United Kingdom. In Nature, 2013
The one-electron reduction of nitrite to NO, a precursor to N2O, is performed by either a haem- or copper-containing nitrite reductase (CuNiR) where they receive an electron from redox partner proteins a cupredoxin or a c-type cytochrome.
Probing single biomolecules in solution using the anti-Brownian electrokinetic (ABEL) trap.
Impact
Moerner et al., Stanford, United States. In Acc Chem Res, 2012
We have applied the ABEL trap method to explore the photodynamics and enzymatic properties of a variety of biomolecules in aqueous solution and present four examples: the photosynthetic antenna allophycocyanin, the chaperonin enzyme TRiC, a G protein-coupled receptor protein, and the blue nitrite reductase redox enzyme.
Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits.
GeneRIF
Ke et al., Beijing, China. In Plos One, 2011
A transcriptional repressor NIR functions in the rRNA biogenesis of both the 40S and 60S subunits.
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
Impact
GeneRIF
Song et al., Guangzhou, China. In Cancer Cell, 2011
CCL18 derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.
Chemokines and cancer: a fatal attraction.
Impact
Mantovani et al., Milano, Italy. In Cancer Cell, 2011
Unexpectedly, PITPNM3/Nir1, a molecule unrelated to chemokine receptors, was identified as its elusive receptor.
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
GeneRIF
Jain et al., Bethesda, United States. In J Biol Chem, 2011
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression.
PITPNM3 is an uncommon cause of cone and cone-rod dystrophies.
GeneRIF
Golovleva et al., Umeå, Sweden. In Ophthalmic Genet, 2010
Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.
Identification of a nitrate-responsive cis-element in the Arabidopsis NIR1 promoter defines the presence of multiple cis-regulatory elements for nitrogen response.
GeneRIF
Yanagisawa et al., Tokyo, Japan. In Plant J, 2010
The NIR1 promoter contains a cis-element is specifically involved in nitrate signaling but not in feedback repression.
Structural basis of inter-protein electron transfer for nitrite reduction in denitrification.
Impact
Suzuki et al., Toyonaka, Japan. In Nature, 2009
Copper-containing nitrite reductase (CuNIR) is a key enzyme in the process; it produces a precursor for N(2)O by catalysing the one-electron reduction of nitrite (NO2-) to nitric oxide (NO).
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