gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Zinc and ring finger 1

Nin283, ZNRF1
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, V1a, CAN, Akt, FIF
Papers on Nin283
Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
New
Araki et al., Kodaira, Japan. In J Cell Biol, Dec 2015
We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation.
Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.
New
Jia et al., Shanghai, China. In Diabetologia, Jun 2015
RESULTS: rs17684886 in ZNRF1 and rs599019 near COLEC12 were associated with diabetic retinopathy (OR 0.812, p = 0.0039 and OR 0.835, p = 0.0116, respectively) and with the severity of diabetic retinopathy (p = 0.0365 and p = 0.0252, respectively, for trend analysis).
PAX5 alteration-associated gene-expression signatures in B-cell acute lymphoblastic leukemia.
Huang et al., Wuhan, China. In Int J Hematol, 2013
The results showed that cases of PAX5 alteration can cluster using unsupervised clustering algorithms, and one gene, zinc and ring finger 1 (ZNRF1), was characterized and validated by quantitative RT-PCR.
ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.
MacKintosh et al., Dundee, United Kingdom. In J Cell Sci, 2012
Here, we describe a phosphorylation-based reverse myristoyl switch for mammalian ZNRF2, and show that this E3 ubiquitin ligase and its sister protein ZNRF1 regulate the Na(+)/K(+) pump (Na(+)/K(+)ATPase).
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Impact
Araki et al., Kodaira, Japan. In Nat Cell Biol, 2011
Here we show that ZNRF1, an E3 ligase, promotes Wallerian degeneration by targeting AKT to degrade through the UPS.
Proteasomal degradation of glutamine synthetase regulates schwann cell differentiation.
Araki et al., Kodaira, Japan. In J Neurosci, 2010
These phenotypic changes are required for efficient degeneration/regeneration. We previously identified ZNRF1 as an E3 ubiquitin ligase containing a RING finger motif, whose expression is upregulated in the Schwann cells following nerve injury.
ZNRF1 interacts with tubulin and regulates cell morphogenesis.
GeneRIF
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2009
These results suggest that ZNRF1 mediates regulation of neuritogenesis via interaction with tubulin.
ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.
GeneRIF
Milbrandt et al., Saint Louis, United States. In J Neurosci, 2003
data suggest that ZNRF proteins play a role in the establishment and maintenance of neuronal transmission and plasticity via their ubiquitin ligase activity
Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery.
Milbrandt et al., Saint Louis, United States. In J Biol Chem, 2001
We chose one representative gene, nin283, to analyze in detail.
share on facebooktweetadd +1mail to friends