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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholinergic receptor, nicotinic, alpha 2

nicotinic acetylcholine receptor
agonist-binding subunit of neuronal nicotinic acetylcholine receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, ACID, iMpact
Papers on nicotinic acetylcholine receptor
The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex.
Review
New
Leite et al., Niterói, Brazil. In J Cell Physiol, Feb 2016
In this review, we discuss important advances, conflicting and controversial findings regarding the involvement of parasympathetic vagus and sympathetic splenic nerve through acetylcholine (ACh) release and α7 nicotinic acetylcholine receptor (nAChRα7) activation in the spleen.
CHRNA5/CHRNA3 Locus Associates with Increased Mortality among Smokers.
New
Laitinen et al., Turku, Finland. In Copd, Feb 2016
UNASSIGNED: Polymorphisms in the nicotinic acetylcholine receptor gene (CHRNA5/CHRNA3 locus) have been associated with several smoking related traits such as nicotine dependence, cigarette consumption, smoking cessation, lung cancer, and COPD.
Subtype-selective Nicotinic Acetylcholine Receptor agonists can improve Cognitive Flexibility in an Attentional Set Shifting Task.
New
Shoaib et al., Newcastle, South Africa. In Neuropharmacology, Feb 2016
UNASSIGNED: Nicotinic acetylcholine receptors (nAChRs) are considered to be viable targets to enhance cognition in patients diagnosed with schizophrenia.
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: focus on cell type differences.
Review
New
Saito et al., Hiroshima, Japan. In Neuropharmacology, Feb 2016
Following this initial step, the KP has 2 distinct branches; one branch is regulated by kynurenine 3-monooxygenase (KMO) and is primarily responsible for the 3-HK and QUIN production, and the other branch is regulated by kynurenine aminotransferase (KAT), which produces KYNA, an N-methyl-D-aspartate receptor and alpha-7-nicotinic acetylcholine receptor antagonist.
Inhibitory effects of nicotine derived from cigarette smoke on thymic stromal lymphopoietin production in epidermal keratinocytes.
New
Hirasawa et al., Sendai, Japan. In Cell Immunol, Feb 2016
Nicotine inhibition of TSLP production was abolished by pretreatments with α7 nicotinic acetylcholine receptor (α7 nAChR) antagonists, AMP-activated protein kinase (AMPK) inhibitor, and phosphoinositide 3-kinase (PI3K) inhibitors.
Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.
New
Wolstenholme et al., Athens, United States. In Mol Biochem Parasitol, Jan 2016
UNASSIGNED: The levamisole-sensitive nicotinic acetylcholine receptor present at nematode neuromuscular junctions is composed of multiple different subunits, with the exact composition varying between species.
Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstem.
New
Machaalani et al., Australia. In Neurotoxicology, Jan 2016
UNASSIGNED: Infants exposed to cigarette smoked during pregnancy into infancy have increased respiratory and cardiac abnormalities.
Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
Review
New
Christie et al., Sydney, Australia. In Toxins (basel), Oct 2015
The α9α10-nicotinic acetylcholine receptor (nAChR) has been implicated in pain and has been proposed to be a novel target for analgesics.
Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment.
Review
New
Impact
Sine et al., Rochester, United States. In Lancet Neurol, Apr 2015
Most CMS stem from molecular defects in the muscle nicotinic acetylcholine receptor, but they can also be caused by mutations in presynaptic proteins, mutations in proteins associated with the synaptic basal lamina, defects in endplate development and maintenance, or defects in protein glycosylation.
Cytisine versus nicotine for smoking cessation.
Impact
Bullen et al., Auckland, New Zealand. In N Engl J Med, 2015
BACKGROUND: Placebo-controlled trials indicate that cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6 months.
Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective.
Review
Clarkson et al., Dunedin, New Zealand. In Int J Mol Sci, 2014
Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor (α7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients.
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine.
Review
Dani, Philadelphia, United States. In Int Rev Neurobiol, 2014
Nicotinic acetylcholine receptors (nAChRs) belong to the "Cys-loop" superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors.
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.
Impact
Heinis et al., Lausanne, Switzerland. In Nat Chem, 2014
Application of Dtaas to a serine protease inhibitor and a nicotinic acetylcholine receptor inhibitor that contain disulfide constraints enhanced their inhibitory activities 40- and 7.6-fold, respectively.
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Impact
Gouaux et al., Portland, United States. In Nature, 2014
Structural information for Cys-loop receptors comes from several sources including electron microscopic studies of the nicotinic acetylcholine receptor, high-resolution X-ray structures of extracellular domains and X-ray structures of bacterial orthologues.
50 years of allosteric interactions: the twists and turns of the models.
Impact
Changeux, Paris, France. In Nat Rev Mol Cell Biol, 2013
Many classic regulatory proteins (including haemoglobin, Asp transcarbamylase and nicotinic acetylcholine receptor) follow the central paradigm of the MWC model, which has been expanded and challenged as a result of novel technologies.
Alpha2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits.
GeneRIF
Sumikawa et al., Irvine, United States. In Eur J Neurosci, 2009
Results suggest that nicotine alters the normal operation of hippocampal circuits by gating inhibitory circuits through activating a non-desensitizing alpha2 nAChR subtype on a distinct population of interneurons.
Postnatal expression of alpha2 nicotinic acetylcholine receptor subunit mRNA in developing cortex and hippocampus.
GeneRIF
Winzer-Serhan et al., College Station, United States. In J Chem Neuroanat, 2006
Similar to other nAChR subunits, alpha2 mRNA expression is transiently upregulated during postnatal development and nAChRs containing alpha2 subunits could regulate GABAergic activity during a critical period of network formation.
Rat nicotinic acetylcholine receptor alpha2beta2 channels: comparison of functional properties with alpha4beta2 channels in Xenopus oocytes.
GeneRIF
Yakel et al., United States. In Neuroscience, 2003
At least two different affinity sites for acetylcholine. Sensitivity to block of alpha4beta2 channels by dihydro-beta-erythroidine was higher than that for alpha2beta2. Current-voltage for alpha2beta2 more strongly rectified than for alpha4beta2.
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