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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nicotinamide N-methyltransferase

nicotinamide N-methyltransferase, NNMT
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, fibrillin-1, ACID, V1a
Papers on nicotinamide N-methyltransferase
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
New
Impact
Ruohola-Baker et al., Seattle, United States. In Nat Cell Biol, Dec 2015
We now show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs).
1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.
New
Uzu et al., Ōtsu, Japan. In Free Radic Biol Med, Dec 2015
Among 19 candidate enzymes involved in mammalian NAD metabolism, the mRNA expression level of nicotinamide n-methyltransferase (NNMT) was significantly increased in both the kidneys of FFA-albumin-overloaded mice and cultured PTCs stimulated with palmitate-albumin.
Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3.
New
Parsons et al., Porto Alegre, Brazil. In Biochem Biophys Res Commun, Dec 2015
Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1)
Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents.
New
Kim et al., Seoul, South Korea. In J Med Chem, Nov 2015
Our studies suggest that the inhibition of cancer cell growth by 5b is associated with the induction of G0/G1 cell cycle arrest via nicotinamide N-methyltransferase-dependent JNK activation in Caki-1 renal cancer cells.
NNMT: A Bad Actor in Fat Makes Good in Liver.
New
Impact
Brenner et al., Iowa City, United States. In Cell Metab, Sep 2015
High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity.
Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.
New
Fang et al., Nanjing, China. In J Clin Endocrinol Metab, Aug 2015
CONTEXT: Nicotinamide N-methyltransferase (NNMT) is a novel histone methylation modulator that regulates energy metabolism, and NNMT knockdown prevents diet-induced obesity in mice.
Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.
New
Impact
Pissios et al., Boston, United States. In Nat Med, Aug 2015
Nicotinamide N-methyltransferase (Nnmt) methylates nicotinamide, a form of vitamin B3, to produce N(1)-methylnicotinamide (MNAM).
Association of Nicotinamide-N-Methyltransferase Gene rs694539 Variant with Epilepsy.
New
Idrisoglu et al., Kocaeli, Turkey. In Mol Neurobiol, Aug 2015
This finding, for the first time, suggests the involvement of the NNMT gene rs694539 variant in the etiology of epilepsy.
Identification and characterization of cancer stem cells from head and neck squamous cell carcinoma cell lines.
Emanuelli et al., Ancona, Italy. In Cell Physiol Biochem, 2014
In addition, we investigated the expression levels of Nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in several malignancies.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Impact
Kahn et al., Boston, United States. In Nature, 2014
Here we show, using DNA array analyses, that nicotinamide N-methyltransferase (Nnmt) is the most strongly reciprocally regulated gene when comparing gene expression in white adipose tissue (WAT) from adipose-specific Glut4-knockout or adipose-specific Glut4-overexpressing mice with their respective controls.
Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels.
GeneRIF
Agam et al., Beersheba, Israel. In Int J Neuropsychopharmacol, 2012
This study suggested that NNMT is involved in the aetiology of schizophrenia
Structural basis of substrate recognition in human nicotinamide N-methyltransferase.
GeneRIF
Yee et al., Cleveland, United States. In Biochemistry, 2011
Structural basis of substrate recognition in human nicotinamide N-methyltransferase
Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice.
GeneRIF
Agam et al., Beersheba, Israel. In J Psychopharmacol, 2011
Brain NNMT expression was not altered in hyperhomocysteinemia.
Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells.
GeneRIF
Lin et al., Taipei, Taiwan. In Carcinogenesis, 2011
NNMT has a crucial role in cellular invasion via activating PI3K/Akt/SP1/MMP-2 pathway in clear cell renal cell carcinoma (ccRCC).
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.
Review
Kaspers et al., Amsterdam, Netherlands. In Br J Haematol, 2010
Polymorphisms in other folate related genes (MTRR, MTR [MS], TYMS [TS], SLC19A1 [RFC1], NNMT, and SHMT1) are less clearly associated with susceptibility to ALL, and the number of included studies on this subject in this review is limited.
Homocyst(e)ine and stroke.
Review
Kelly et al., Boston, United States. In Semin Neurol, 2006
Emerging evidence suggests that genetic variation within this pathway, such as the methyleneterahydrofolate reductase and cystathionine beta-synthase and nicotinamide N-methyltransferase genes, increases the risk of ischemic stroke.
Parkinson's disease: the first common neurological disease due to auto-intoxication?
Review
Ramsden et al., Birmingham, United Kingdom. In Qjm, 2005
MPP+) are well-established dopaminergic toxins, and the xenobiotic enzyme nicotinamide N-methyltransferase (NNMT) can convert pyridines such as 4-phenylpyridine into MPP+, using S-adenosyl methionine (SAM) as the methyl donor.
Autotoxicity, methylation and a road to the prevention of Parkinson's disease.
Review
Ramsden et al., Birmingham, United Kingdom. In J Clin Neurosci, 2005
The enzyme nicotinamide N-methyltransferase (NNMT) can covert otherwise harmless pyridines such as 4-phenylpyridine into MPP+ like compounds.
N-methylation underlying Parkinson's disease.
Review
Awaya et al., Asahikawa, Japan. In Neurotoxicol Teratol, 2002
The protein amount of nicotinamide N-methyltransferase (NNMT) was also significantly higher in younger PD patients than that in younger controls.
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