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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Solute carrier family 9

Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009] (from NCBI)
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Papers on NHE8
Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
the role of NHE8 in the intestine involves both sodium absorption and bicarbonate secretion
Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.
Moe et al., Los Angeles, United States. In J Pediatr Gastroenterol Nutr, 2011
Exonic mutations in NHE8 cannot account for congenital sodium diarrhea.
NHE2X3 DKO mice exhibit gender-specific NHE8 compensation.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, 2011
intestinal NHE8 has a compensatory role in NHE2X3 DKO mice and this regulation is gender-dependent.
Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.
Kanazawa et al., Toyonaka, Japan. In Biochemistry, 2011
This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane.
The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.
Bowers et al., London, United Kingdom. In Mol Biol Cell, 2010
These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology.
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