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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier family 9

Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009] (from NCBI)
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Top mentioned proteins: ACID, HAD, V1a, AGE, DRA
Papers on NHE8
Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
We have reported that sodium/hydrogen exchanger (NHE) 8 is a novel player in mucosal protection, since loss of NHE8 function resulted in reduced mucin production and increased bacterial adhesion.
Loss of NHE8 expression impairs intestinal mucosal integrity.
Ghishan et al., Chongqing, China. In Am J Physiol Gastrointest Liver Physiol, Jan 2016
The newest member of the Na(+)/H(+) exchanger (NHE) family, NHE8, is abundantly expressed at the apical membrane of the intestinal epithelia.
Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, Oct 2015
Although NHE8, the newest addition of intestinal NHE family, is involved in sodium absorption in the intestinal tract, whether butyrate modulates NHE8 expression in the intestinal epithelial cells is not known.
Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction.
Jackson et al., Edinburgh, United Kingdom. In Invest Ophthalmol Vis Sci, May 2015
PURPOSE: As part of a large scale systematic screen to determine the effects of gene knockout mutations in mice, a retinal phenotype was found in mice lacking the Slc9a8 gene, encoding the sodium/hydrogen ion exchange protein NHE8.
Disruption of NHE8 expression impairs Leydig cell function in the testes.
Ghishan et al., Tucson, United States. In Am J Physiol Cell Physiol, Mar 2015
NHE8, the most recently characterized NHE family member, is detected in the Leydig cells in humans and mice in great abundance by immunohistochemistry in the current study.
Renal NHE expression and activity in neonatal NHE3- and NHE8-null mice.
Baum et al., Dallas, United States. In Am J Physiol Renal Physiol, 2015
NHE8 has been localized to the brush-border membrane of proximal tubules and is more highly expressed in neonates than in adult animals.
Loss of NHE8 expression impairs ocular surface function in mice.
Ghishan et al., Shenyang, China. In Am J Physiol Cell Physiol, 2015
Although NHE8 has broad tissue distribution, the precise location and the physiological role of NHE8 in the eye remain unknown.
NHE8 is essential for RPE cell polarity and photoreceptor survival.
Gong et al., Berkeley, United States. In Sci Rep, 2014
Chromosomal mapping and DNA sequencing reveal a point mutation (T to A) of the Slc9a8 gene, resulting in mutant sodium/proton exchanger 8 (NHE8)-M120K protein.
Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model.
Xie et al., Beijing, China. In Cancer Lett, 2014
The fusion genes EIF2AK1-ATR and GLYR1-SLC9A8 were predicted to be damaging and oncogenic.
Glucocorticoids Reduce Renal NHE8 Expression.
Baum et al., Dallas, United States. In Physiol Rep, 2013
We have previously demonstrated that there is an isoform switch during postnatal maturation from NHE8 to NHE3 that is concordant with the postnatal increase in serum glucocorticoid levels.
Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, 2012
the role of NHE8 in the intestine involves both sodium absorption and bicarbonate secretion
Small intestinal ion transport.
Kiela et al., Tucson, United States. In Curr Opin Gastroenterol, 2012
We continue to accumulate novel information about the function and regulation of NHE3 (including its role in regulating paracellular Ca2+ flux), NHE8, as well as about the complexity of the intestinal Cl- and HCO3- transport in health and disease.
Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.
Moe et al., Los Angeles, United States. In J Pediatr Gastroenterol Nutr, 2011
Exonic mutations in NHE8 cannot account for congenital sodium diarrhea.
Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters.
Dudeja et al., Chicago, United States. In Biochem J, 2011
The information available on the transcriptional regulation of the recently identified NHE8 isoform is also highlighted.
NHE2X3 DKO mice exhibit gender-specific NHE8 compensation.
Ghishan et al., Tucson, United States. In Am J Physiol Gastrointest Liver Physiol, 2011
intestinal NHE8 has a compensatory role in NHE2X3 DKO mice and this regulation is gender-dependent.
Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions.
Kanazawa et al., Toyonaka, Japan. In Biochemistry, 2011
This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane.
The sodium/proton exchanger NHE8 regulates late endosomal morphology and function.
Bowers et al., London, United Kingdom. In Mol Biol Cell, 2010
These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology.
Luminal Na(+)/H (+) exchange in the proximal tubule.
Moe et al., Dallas, United States. In Pflugers Arch, 2009
Two isoforms, NHE3 and NHE8, are expressed at the luminal membrane of the proximal tubule.
Developmental changes in proximal tubule NaCl transport.
Baum, Dallas, United States. In Pediatr Nephrol, 2008
NHE8, an isoform of the Na(+)/H(+) exchange, in low abundance on the apical membrane of the adult proximal tubule, is present in high abundance in the neonatal segment.
Na+/H+ exchangers in renal regulation of acid-base balance.
Moe et al., Dallas, United States. In Semin Nephrol, 2006
Five of the 10 isoforms (NHE1-4 and NHE8) are expressed at the plasma membrane of renal epithelial cells.
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