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Na+/H+ exchanger domain containing 2

NHA2, Nhe10, Nhedc2, NHA-oc
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: ACID, CAN, ATPase, CPA2, OUT
Papers on NHA2
Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
New
Dow et al., Glasgow, United Kingdom. In Proc Natl Acad Sci U S A, Oct 2015
In Drosophila, as in humans, they are represented by two genes, Nha1 (Slc9b1) and Nha2 (Slc9b2), which are enriched and functionally significant in renal tubules.
Bone formation in mono cortical mandibular critical size defects after augmentation with two synthetic nanostructured and one xenogenous hydroxyapatite bone substitute - in vivo animal study.
New
Gundlach et al., Rostock, Germany. In Clin Oral Implants Res, Jul 2015
Randomized augmentation procedures with NanoBone(®) (NHA1), Ostim(®) (NHA2) or Bio-Oss(®) (DBBM) were conducted (each material n = 12).
Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody.
New
Makihira et al., Hiroshima, Japan. In Cell Biol Int, Jun 2015
NHE10 mRNA expression and OC differentiation markers were increased by sRANKL stimulation in dose- and time-dependent manners.
Incorporation of RANKL promotes osteoclast formation and osteoclast activity on β-TCP ceramics.
Klenke et al., Bern, Switzerland. In Bone, 2014
Additionally, the expression of transcripts encoding the osteoclast gene products cathepsin K, calcitonin receptor, and of the sodium/hydrogen exchanger NHA2 were quantified by real-time PCR.
Role of Na/H exchange in insulin secretion by islet cells.
Review
Fuster et al., Bern, Switzerland. In Curr Opin Nephrol Hypertens, 2014
Several isoforms are expressed in β cells of the endocrine pancreas, including the recently discovered and poorly characterized isoform NHA2.
Expression control of nitrile hydratase and amidase genes in Rhodococcus erythropolis and substrate specificities of the enzymes.
Pátek et al., Praha, Czech Republic. In Antonie Van Leeuwenhoek, 2014
The nucleotide sequences of the gene clusters containing the oxd (aldoxime dehydratase), ami (amidase), nha1, nha2 (subunits of the nitrile hydratase), nhr1, nhr2, nhr3 and nhr4 (putative regulatory proteins) genes of two R. erythropolis strains, A4 and CCM2595, were determined.
Traditional and emerging roles for the SLC9 Na+/H+ exchangers.
Review
Alexander et al., Bern, Switzerland. In Pflugers Arch, 2014
The SLC9B subgroup consists of two recently cloned isoforms, NHA1 and NHA2 (SLC9B1 and SLC9B2, respectively).
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cells.
Fuster et al., Bern, Switzerland. In Proc Natl Acad Sci U S A, 2013
NHA2 is a sodium/hydrogen exchanger with unknown physiological function.
The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.
Aliprantis et al., Boston, United States. In Bone, 2012
Here, five novel RANKL-induced, NFATc1-dependent transcripts in the osteoclast are described: Nhedc2, Rhoc, Serpind1, Adcy3 and Rab38.
Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradient.
Rao et al., Baltimore, United States. In J Biol Chem, 2012
Human NHA2, a newly discovered cation proton antiporter, is implicated in essential hypertension by gene linkage analysis.
Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae.
GeneRIF
Battaglino et al., Beijing, China. In Biochim Biophys Acta, 2010
mutation in AA residues V161 and F357 reduced ability of transfected BW31a cells to remove intracellular Na and grow in NaCl-medium; yeast expressing F357 F437 cannot grow in 0.4M NaCl, suggesting these residues also essential for antiporter activity
Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo.
GeneRIF
Fuster et al., Bern, Switzerland. In Bone, 2010
These data from NHA2-deficient mice suggest that NHA2 is dispensable for osteoclast differentiation and bone resorption both in vitro and in vivo.
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension.
GeneRIF
Ben-Tal et al., Tel Aviv-Yafo, Israel. In J Mol Biol, 2010
cluster of essential, highly conserved titratable residues located in an assembly region made of two discontinuous helices of inverted topology, each interrupted by an extended chain
Can we generate new hypotheses about Dent's disease from gene analysis of a mouse model?
Guggino, Baltimore, United States. In Exp Physiol, 2009
The sodium-proton exchanger-like protein, Nhe10/sperm, encoded by Slc9a10, has a 0.5-fold decrease in transcript number.
Early death of Japanese encephalitis virus-infected mice administered a neutralizing cross-reactive monoclonal antibody against glycoprotein E.
Koshy et al., Pune, India. In Acta Virol, 2008
UNLABELLED: In the present study, the effect of two haemagglutination-inhibition (HAI)-negative auto-reactive (NHA-1 and NHA-2) monoclonal antibodies (MAbs) against glycoprotein E (gpE) of Japanese encephalitis virus (JEV) administered 1 day before or 2 days after intracerebral (i.c.) inoculation of JEV was studied in mice.
Characterization of the sodium/hydrogen exchanger NHA2.
GeneRIF
Moe et al., Bern, Switzerland. In J Am Soc Nephrol, 2008
restricted to the distal convoluted tubule in the kidney
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.
GeneRIF
Rao et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2007
Na+/H+ antiporter genes may contribute to sodium-lithium countertransport activity and salt homeostasis in humans[NHA1 and NHA2]
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