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proteins. Page last changed on 19 Dec 2016.
Reticulon 4 receptor
NgR, Nogo receptor, Nogo-66 receptor
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008] (from
Wang et al., Chongqing, China. In Curr Pharm Des, Jan 2016
Interestingly, these three structurally different inhibitors share two common receptors, Nogo-66 receptor (NgR) and paired immunoglobulin-like receptor B (PirB), and transduce the inhibitory signal into neurons via their complex combinant and co-receptors, such as p75 neurotrophin receptor (p75NTR), Nogo receptor-interacting protein 1 (LINGO-1), and TROY.
Fu et al., Beijing, China. In Neural Regen Res, Aug 2015
In addition to the Nogo receptor (NgR), the paired immunoglobulin-like receptor B (PirB) is a recently discovered coreceptor of Nogo, myelin-associated glycoprotein, and myelin oligodendrocyte glycoprotein.
Silver et al., Cleveland, United States. In Nature, Mar 2015
Protein tyrosine phosphatase σ (PTPσ), along with its sister phosphatase leukocyte common antigen-related (LAR) and the nogo receptors 1 and 3 (NgR), have recently been identified as receptors for the inhibitory glycosylated side chains of CSPGs.
Giger et al., Ann Arbor, United States. In Nat Neurosci, 2012
The results of this study identify NgR1 and NgR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide evidence for shared mechanisms of MAI and CSPG inhibition.
Luo et al., Guangzhou, China. In Mol Med Report, 2012
The overexpression of Nogo-A and the activation of NgR inhibit neurite outgrowth and alter neuronal metabolism, resulting in overproduction and/or release of Abeta, which in turn may trigger the onset and development of AD.
Greenberg et al., Boston, United States. In Neuron, 2012
The results of this study suggested that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development.
Strittmatter et al., New Haven, United States. In Science, 2005
mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity; physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity
Strittmatter et al., New Haven, United States. In Science, 2002
Myelin-associated glycoprotein(MAG) binds directly, with high affinity, to NgR; MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury