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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neurogenin 3

Ngn3, neurogenin 3, Neurog3
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Insulin, PDX-1, CAN, Glucagon, FATE
Papers on Ngn3
Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice.
Zhou et al., Boston, United States. In Diabetologia, Jan 2016
AIMS/HYPOTHESIS: Reprogramming of pancreatic exocrine to insulin-producing cells by viral delivery of the genes encoding transcription factors neurogenin-3 (Ngn3), pancreas/duodenum homeobox protein 1 (Pdx1) and MafA is an efficient method for reversing diabetes in murine models.
NADPH Oxidase-Dependent Reactive Oxygen Species Stimulate β-Cell Regeneration Through Differentiation of Endocrine Progenitors in Murine Pancreas.
Leung et al., Hong Kong, Hong Kong. In Antioxid Redox Signal, Jan 2016
Studies performed in streptozotocin (STZ)-injected neonatal rats showed that diphenyleneiodonium (DPI) obstructed β-cell regeneration through the suppression of neurogenin 3 (NGN3) expression, but not Ki67-labeling β-cells, indicating that ROS stimulation promoted differentiation beyond proliferation of β-cells.
Mutant neurogenin-3 in a Turkish boy with congenital malabsorptive diarrhea.
Dalgıç et al., Ankara, Turkey. In Pediatr Int, Dec 2015
Neurogenin-3 mutation, a very rare form of congenital diarrhea, disrupts enteroendocrine cell differentiation and is characterized by malabsorption and the absence of pancreatic islet cells.
Mechanism study for hypoxia induced differentiation of insulin-producing cells from umbilical cord blood-derived mesenchymal stem cells.
Xiao et al., Nanjing, China. In Biochem Biophys Res Commun, Nov 2015
We found that hypoxia induced c-MET elevation is efficiently initiated the early stage differentiation IPCs from MSCs, and HGF improved the fully differentiation of IPCs by inducing the expression of NGN3.
Pax4 acts as a key player in pancreas development and plasticity.
Collombat et al., Nice, France. In Semin Cell Dev Biol, Aug 2015
Neurogenin3 (Neurog3) initiates the endocrine program by activating the expression of additional transcription factors driving survival, proliferation, maturation and lineage allocation of endocrine precursors.
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids.
Wells et al., Cincinnati, United States. In Nature, 2015
We used hGO cultures to identify novel signalling mechanisms that regulate early endoderm patterning and gastric endocrine cell differentiation upstream of the transcription factor NEUROG3.
Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors.
Sharma et al., Boston, United States. In Plos One, 2014
The increase in endocrine cells resulted from a higher proliferation of tubular epithelial cells expressing the progenitor marker Glut2 in E17.5 bigenic embryos and increased number of Neurog3-expressing cells at E19.5.
Transcriptional control of spermatogonial maintenance and differentiation.
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Several transcription factors have been identified that promote spermatogonial differentiation (DMRT1, NGN3, SOHLH1, SOHLH2, SOX3, and STAT3); some of these may influence the decision of an SSC to commit to differentiate while others may promote later spermatogonial differentiation steps.
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.
Remedi et al., Saint Louis, United States. In Cell Metab, 2014
In the diabetic state, β cells lose their mature identity and dedifferentiate to neurogenin3-positive and insulin-negative cells.
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.
Sander et al., San Diego, United States. In Development, 2012
Although Sox9 is required for Ngn3 induction, endocrine differentiation necessitates subsequent Sox9 downregulation and evasion from Notch activity via cell-autonomous repression of Sox9 by Ngn3.
NEUROG3 is a critical downstream effector for STAT3-regulated differentiation of mammalian stem and progenitor spermatogonia.
Oatley et al., Pullman, United States. In Biol Reprod, 2012
The results established a mechanism by which activation of STAT3 regulates the expression of NEUROG3 to subsequently drive differentiation of spermatogonial stem cells and progenitor spermatogonia.
α-cell role in β-cell generation and regeneration.
Stanojevic et al., Boston, United States. In Islets, 2012
GLP-1, a cell growth and survival factor, is proposed to promote the expansion of neurogenin3-expressing, undifferentiated pro-α-cells during development.
Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
Accili et al., New York City, United States. In Nat Genet, 2012
Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express markers of mature β cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas.
Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA.
Slack et al., Minneapolis, United States. In Biochem J, 2012
mechanism of transdifferentiation of pancreatic exocrine cells to beta (beta) cells in vivo by Ngn3
CCAR1 is required for Ngn3-mediated endocrine differentiation.
Chiang et al., T'ai-chung-shih, Taiwan. In Biochem Biophys Res Commun, 2012
CCAR1 is a novel partner of Ngn3 in mediating endocrine differentiation.
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
Heimberg et al., Brussels, Belgium. In Plos One, 2011
Ngn3-mediated pancreatic duct-to-endocrine cell reprogramming was measured employing genome wide mRNA profiling.
Transcriptional regulation of α-cell differentiation.
Kaestner et al., Philadelphia, United States. In Diabetes Obes Metab, 2011
Many transcription factors, such as neurogenin 3 (Ngn3), pancreatic duodenal homeobox 1 (Pdx1) and regulatory factor x6 (Rfx6), play a crucial role in the determination of the endocrine cell fate, while other transcription factors, such as aristaless-related homeobox (Arx) and forkhead box A2 (Foxa2), are implicated in the initial or terminal differentiation of α-cells.
Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation.
Leiter et al., Worcester, United States. In Diabetes Obes Metab, 2011
Differentiation of enteroendocrine cells is controlled by the sequential expression of three basic helix-loop-helix transcription factors, Math1, Neurogenin 3 (Neurog3) and NeuroD.
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Wells et al., Cincinnati, United States. In Nature, 2011
We also determined that NEUROG3, a pro-endocrine transcription factor that is mutated in enteric anendocrinosis, is both necessary and sufficient for human enteroendocrine cell development in vitro.
Rfx6 directs islet formation and insulin production in mice and humans.
German et al., San Francisco, United States. In Nature, 2010
During embryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of the beta-cells and other islet cell types from pancreatic endoderm, but the genetic program that subsequently completes this differentiation remains incompletely understood.
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