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Neurogenin 2

Ngn2, Neurogenin2, Neurog2
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis from migratory neural crest cells.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: FATE, CAN, Grb2, AKA, ACID
Papers using Ngn2 antibodies
Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, MSX1, Ngn2, and Pitx3.
Reh Thomas A., In PLoS ONE, 2007
... The creation of the Ngn2 transgenic mice was reported elsewhere ...
Papers on Ngn2
Generation of functional human serotonergic neurons from fibroblasts.
Gage et al., Los Angeles, United States. In Mol Psychiatry, Jan 2016
FEV, GATA2 and LMX1B in combination with ASCL1 and NGN2 directly and efficiently generated serotonergic neurons from human fibroblasts.
Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System.
Liu et al., Houston, United States. In Stem Cells Dev, Jan 2016
We have developed a fast and precise clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) technology-based method and obtained fluorescent protein and antibiotic resistance dual knockin reporters in hiPSC lines for neurogenin2 (NEUROG2), an important proneural transcription factor.
Interferon-gamma inhibits the neuronal differentiation of neural progenitor cells by inhibiting the expression of Neurogenin2 via the JAK/STAT1 pathway.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, Nov 2015
Interestingly, the expression of one of proneural genes, Neurogenin2 (Neurog2) was dramatically inhibited upon IFN-γ treatment, and cells overexpressing Neurog2 did not respond to IFN-γ.
Pax6 influences expression patterns of genes involved in neuro- degeneration.
Mishra et al., Benares, India. In Ann Neurosci, Oct 2015
RESULTS: The levels of expression of transcripts of some of the proposed putative markers of neurodegeneration like Pax6, S100β, GFAP, BDNF, NGN2, p73α, p73δ, LDH, SOD, and Catalase were analyzed in Pax6 knockdown condition for analysis of role of Pax6 in neurodegeneration.
Differentiation of stem cells derived from carious teeth into dopaminergic-like cells.
Abu Kasim et al., Putrajaya, Malaysia. In Int Endod J, Oct 2015
Amongst the notable genes were those from the transcription factors family (FLNA, MEF2C, NEUROG2), signalling pathway family (DLL1, Notch1, TGF-β1), neuro-inducer family (BDNF) and cell communication family (APBB1).
CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons.
Thomaidou et al., Athens, Greece. In Stem Cell Reports, Oct 2015
Here we explored the effect of CEND1 and NEUROG2 on reprogramming of mouse cortical astrocytes and embryonic fibroblasts.
Ethanol-related alterations in gene expression patterns in the developing murine hippocampus.
Chai et al., Ansan, South Korea. In Acta Biochim Biophys Sin (shanghai), Aug 2015
Microarray analysis revealed that Nova1, Ntng1, Gal, Neurog2, Neurod2, and Fezf2 gene expressions are altered in the fetal hippocampus.
Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes.
Götz et al., München, Germany. In Cell Stem Cell, Aug 2015
Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons.
Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis.
Storey et al., Dundee, United Kingdom. In Science, 2014
We further show that N-cadherin levels, regulated by neuronal-differentiation factor Neurog2, determine cilium disassembly and final abscission.
Proneural genes in neocortical development.
Schuurmans et al., Calgary, Canada. In Neuroscience, 2014
In particular, we focus on the proneural genes Neurogenin 1 (Neurog1), Neurog2 and Achaete scute-like 1 (Ascl1), which are each expressed in a distinct fashion in the progenitor cell pools that give rise to all of the neuronal and glial cell types of the mature neocortex.
Neurogenin 2 regulates progenitor cell-cycle progression and Purkinje cell dendritogenesis in cerebellar development.
Consalez et al., Milano, Italy. In Development, 2012
It was shown that, in the cerebellar primordium, neurogenin 2 is expressed by cycling progenitors fated to become Purkinje cells. During cerebellar development, neurogenin 2 is expressed in G1 phase by progenitors poised to exit the cell cycle.
Drosha regulates neurogenesis by controlling neurogenin 2 expression independent of microRNAs.
Taylor et al., Freiburg, Germany. In Nat Neurosci, 2012
Loss of microprocessor activity results not only in an increase Ngn2 protein but also extended expression of Neurog2 into later stages of the neurogenic lineage.
GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex.
Schuurmans et al., Calgary, Canada. In J Neurosci, 2012
temporal regulation of neurogenin 2 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse
Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation.
Philpott et al., Cambridge, United States. In Development, 2012
NeuroD promoter is substantially more sensitive to the phosphorylation status of Ngn2 than the Delta promoter, and that this can be attributed to differences in the ease of promoter activation.
Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.
Graf et al., Greece. In Plos One, 2011
Data show that Bmp7 regulates Ngn2 steady-state transcript levels in the E14.5 cortex.
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Guillemot et al., London, United Kingdom. In Nature, 2008
results identify Rnd2 as a novel essential regulator of neuronal migration in the cerebral cortex and demonstrate that Rnd2 is a major effector of Neurog2 function in the promotion of migration
Regulation of motor neuron specification by phosphorylation of neurogenin 2.
Greenberg et al., Boston, United States. In Neuron, 2008
The phoshorylation of neurogenin 2 at S231 and S234 facilitates the interaction of neurogenin 2 with homeodomain transcription factors to specify motor neuron identity.
Neurogenesis or neuronal specification: phosphorylation strikes again!
Johnson et al., Dallas, United States. In Neuron, 2008
In this issue of Neuron, Ma et al. discover that phosphorylation via GSK3 of the bHLH factor, Ngn2 (Neurog2), adds a neuronal subtype-specific program to its functional repertoire that is activated in the developing neural tube in vivo.
bHLH genes and retinal cell fate specification.
Wang et al., Birmingham, United States. In Mol Neurobiol, 2005
Photoreceptor genesis appears to employ two transcriptional pathways: ngn2-->neuroD-->raxL and ath5-->neuroD-->raxL. ngn2 and ath5 function in progenitors, which can potentially develop into different cell types.
neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS.
Anderson et al., Pasadena, United States. In Mol Cell Neurosci, 1995
Here we identify two additional ngn's, ngn2 and ngn3, which together define a novel subfamily of atonal-related mouse genes.
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