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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nerve growth factor

NGF, nerve growth factor
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, trkA, Brain-derived neurotrophic factor, V1a, HAD
Papers using NGF antibodies
Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: A possible role of IP3 receptors.
Supplier
Obukhov Alexander G., In PLoS ONE, 2009
... (Wako Pure Chemical Industries, Tokyo, Japan), 2-aminoethoxydiphenyl borate (2-APB) (Calbiochem-Novabiochem Co., San Diego, CA, USA), NGF (Alomone Labs.
Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats
Supplier
Kalisch Bettina E et al., In The Open Biochemistry Journal, 2009
... Harlan Bioproducts for Science (Indianapolis IN) was the supplier for NGF and Sigma Aldrich (St ...
Reduced spinal microglia activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases. [abstract]
Supplier
Ito Seiji et al., In Molecular Pain, 2007
... Louis, MO, USA); 8-Br-cGMP from Calbiochem (La Jolla, CA, USA); nerve growth factor (NGF), roscovitine, and UTP from Wako Pure Chemicals (Osaka, Japan); ATP from Oriental Yeast Co. (Tokyo, Japan); 1-[ ...
Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration
Supplier
Drescher Uwe et al., In Neural Development, 2007
... (Rockville, MD, USA) Anti-FLAG and NGF was from Sigma and αHA from Abcam (Sigma: St ...
Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.
Supplier
Xu Wenqing, In PLoS ONE, 2007
... factors and chemicals were obtained from the following manufacturers: FGF1, FGF2, WNT3a, WNT5a, DKK1, EGF, NGF (R&D Systems, Minneapolis, MN); heparin (Invitrogene); wortmannin, LY294002, U0126 (Cell Signaling, Beverly, MA); tunicamycin (Enzo ...
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Papers on NGF
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.
New
Im et al., Chicago, United States. In Ann Rheum Dis, Feb 2016
Hyperalgesia was associated with stimulation of nerve growth factor (NGF) by fibroblast-like synovial cells and with increased synovial angiogenesis.
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
New
Gulati, Downers Grove, United States. In Curr Neuropharmacol, Feb 2016
Stimulation of ETB receptors in the adult ischemic brain has been found to promote angiogenesis and neurogenesis mediated through vascular endothelial growth factor (VEGF) and nerve growth factor (NGF).
Osteoarthritis year in review 2015: clinical.
Review
New
Sharma, Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Symptom outcomes of pharmacologic treatments were reported for methotrexate, adalimumab, anti-nerve growth factor monoclonal antibodies, strontium ranelate, bisphosphonates, glucosamine, and chondroitin sulfate, and structural outcomes of pharmacologic treatments for strontium ranelate, recombinant human fibroblast growth factor 18, and glucosamine and chondroitin sulfate.
Osteoarthritis year in review 2015: biology.
Review
New
Malfait, Chicago, United States. In Osteoarthritis Cartilage, Jan 2016
Synovitis and synovial expression of the pro-algesic neurotrophin, Nerve Growth Factor, are associated with pain.
Induction of Bladder Overactivity by Nerve Growth Factor in Testes in Rats: Possible Neural Crosstalk Between the Testes and Urinary Bladder.
New
Masuda et al., Tsukuba, Japan. In Low Urin Tract Symptoms, Jan 2016
OBJECTIVES: To clarify the pathophysiological factor underlying neural crosstalk among pelvic organs, we investigated the possible role of nerve growth factor (NGF) in the neural crosstalk between the testes and urinary bladder.
Acute versus chronic phase mechanisms in a rat model of CRPS.
New
Clark et al., Palo Alto, United States. In J Neuroinflammation, Dec 2015
The expression of the neuropeptide signaling molecule substance P (SP), NK1 receptor, inflammatory mediators TNFα, IL-1β, and IL-6 and nerve growth factor (NGF) were elevated at 4 weeks in sciatic nerve and/or skin, returning to normal levels by 16 weeks post fracture.
Modulation of neurotrophic signaling pathways by polyphenols.
Review
New
Firuzi et al., Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Assessment of underlying mechanisms, especially in PC12 neuronal-like cells, reveals that direct agonistic effect on tropomyosin receptor kinase (Trk) receptors, the main receptors of neurotrophic factors including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) explains the action of few polyphenols such as 7,8-dihydroxyflavone.
Therapeutic evaluation of HIV transduction basic domain-conjugated superoxide dismutase solution on suppressive effects of the formation of peroxynitrite and expression of COX-2 in murine skin.
New
Chen et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
In nerve growth factor (NGF) induced differentiated PC12 pheochromocytoma cells, we demonstrated that the denatured Tat-SOD regained its antioxidant activity and effectively protected PC12 cells from DNA fragmentation induced by paraquat.
Chronic Pelvic Ischemia: Contribution to the Pathogenesis of Lower Urinary Tract Symptoms (LUTS): A New Target for Pharmacological Treatment?
Review
Yamaguchi et al., Winston-Salem, United States. In Low Urin Tract Symptoms, 2015
In animal models, chronic ischemia induced by arterial injury and a high-fat diet upregulates markers of oxidative stress and proinflammatory cytokines in the urothelium and lamina propria, and leads to increased expression of nerve growth factor.
Neurologic Regulation and Orthodontic Tooth Movement.
Review
Faber et al., In Front Oral Biol, 2014
The periodontium is a highly innervated structure that also provides the necessary trophic factors, such as nerve growth factor, which promote neuronal survival, maintenance and axonal growth, via interaction with specific nerve surface receptors, such as TrkA.
Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.
Impact
Floto et al., Bethesda, United States. In Science, 2014
We have found that the structurally related cystine-knot protein, nerve growth factor β (NGFβ), plays an unexpected Spaetzle-like role in immunity to Staphylococcus aureus infection in chordates.
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.
Impact
Jaffrey et al., New York City, United States. In Cell, 2014
Here, we show that MICAL-2, an atypical actin-regulatory protein, mediates SRF/MRTF-A-dependent gene transcription elicited by nerve growth factor and serum.
Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
Impact
Doebele et al., Aurora, United States. In Nat Med, 2013
We identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein).
Total synthesis of the Daphniphyllum alkaloid daphenylline.
Impact
Li et al., Shanghai, China. In Nat Chem, 2013
They display a remarkable range of biological activities, including anticancer, antioxidant, and vasorelaxation properties as well as elevation of nerve growth factor.
Neurotrophin regulation of neural circuit development and function.
Review
Impact
Poo et al., Berkeley, United States. In Nat Rev Neurosci, 2013
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function.
Nerve growth factor content is increased in the rectal mucosa of children with diarrhea-predominant irritable bowel syndrome.
GeneRIF
Faure et al., Montréal, Canada. In Neurogastroenterol Motil, 2012
NGF content is increased in rectal mucosa of diarrhea-predominant irritable bowel syndrome children.
NGF-p75 and neuropsin/KLK8 pathways stimulate each other to cause hyperkeratosis and acanthosis in inflamed skin.
GeneRIF
Tohyama et al., In J Dermatol Sci, 2012
Letter: NGF-p75 and neuropsin/KLK8 pathways may cooperate in regulation of epidermal homeostasis in inflamed skin.
Influence of estrogen replacement and aging on the expression of nerve growth factor in the urethra of female rats.
GeneRIF
Sartori et al., São Paulo, Brazil. In Neurourol Urodyn, 2012
Hormonal status led to significant differences in NGF protein expression in urethral epithelium and periurethral smooth muscle of female rats.
[Observation on morphology and nerve growth factor expression in nasal mucosal of depression rats].
GeneRIF
Tao et al., Wuhan, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2012
NGF was expressed in the nasal mucosa of rats with depression.
NGF causes TrkA to specifically attract microtubules to lipid rafts.
GeneRIF
Grimes et al., Palmerston North, New Zealand. In Plos One, 2011
NGF enhanced the interaction between TrkA and microtubules in detergent-resistant membranes.
More papers using NGF antibodies
Adenosine receptors and wound healing, revised
Supplier
Harz Hartmann et al., In Purinergic Signalling, 2005
... FCS (Invitrogen, Karlsruhe, Germany), 100 μg/ml streptomycin, 100 units/ml penicillin and was supplemented with 25 ng/ml 7 S NGF (Becton Dickinson, Franklin Lakes, NJ, USA) ...
Beta1-integrin orients epithelial polarity via Rac1 and laminin
Supplier
ffrench-Constant Charles et al., In The Journal of Cell Biology, 2004
... in DME (Sigma-Aldrich), 10% FCS (Invitrogen) in the presence of 100 ng/ml nerve growth factor (NGF; AbD Serotec).
Secreted gliomedin is a perinodal matrix component of peripheral nerves
Supplier
Peles Elior et al., In The Journal of Cell Biology, 2003
... DRG cultures were grown in Neurobasal medium (Invitrogen) supplemented with B27 (Invitrogen) and 50 ng/ml NGF (Neurobasal medium; Alomone Labs) for 5 d before being ...
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Supplier
Casadesus Gemma, In PLoS ONE, 2001
... Six-months old C57BL×SSJL AD11 anti-NGF mice were produced by breeding single transgenic AD11-VH and AD11-VK mouse ...
Thiol-capping of CdTe nanocrystals: An alternative to organometallic synthetic routes
Supplier
Rochev Yury et al., In Journal of Nanobiotechnology, 2001
... Mouse Nerve Growth Factor (mNGF 2.5S Grade 2) was purchased from Alomone labs.
Capsaicin receptor in the pain pathway
Supplier
Bende Mats et al., In Environmental Health Perspectives, 1999
... Nerve growth factor in standard and samples was bound to an anti-NGF mouse monoclonal antibody coated onto a BD Falcon 96-well microplate (BD Biosciences, Bedford, MA, USA) ...
Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates.
Supplier
Hoyt Kari, In PLoS ONE, 1998
... Nerve growth factor (NGF) was purchased from Alomone Labs Ltd (Jerusalem, Israel) ...
Liposome-mediated NGF gene transfection following neuronal injury: potential therapeutic applications
Supplier
Youn Hwa-Young et al., In Journal of Veterinary Science, 1998
... Cloning of the presumed dog β-NGFGenomic DNA was extracted from the tonsil tissue of a healthy adult male mongrel dog using the DNeasy Tissue Kit (Qiagen, Germany) ...
UniGene
Supplier
Pietu Geneviève et al., In Genome Biology, 1998
... in Leibovitz modified L15 medium (Gibco BRL) supplemented with 2% horse serum and 150 ng/ml NGF (grade II; Alomone Labs, Jerusalem, Israel) as previously ...
Cloning and characterization of human protease-activated receptor 4
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Schemann Michael et al., In Frontiers in Neuroscience, 1997
... Myenteric ganglia were incubated in medium M199 supplemented with 10% FBS (Gibco), 50–100 ng/mL mouse nerve growth factor 7S (Alomone labs, Jerusalem, Israel), 5 mg/mL Glucose, ...
Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
Supplier
Johnson Eugene M. et al., In The Journal of Cell Biology, 1997
... Medium lacking NGF (AM0) consisted of MEM with Earl's salts (Life Technologies) supplemented with 10% FBS, ...
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
Supplier
Miller F.D. et al., In The Journal of Cell Biology, 1997
... the medium supplemented with 3% rat serum (Harlan Sprague Dawley Inc.), 50 ng/ml mouse 2.5 S NGF prepared from mouse salivary gland (Cedarlane Labs, Ltd.), and 0.5% ...
Involvement of caspases in sympathetic neuron apoptosis
Supplier
Boulton Michael E., In PLoS ONE, 1996
... Purified 2.5S-NGF (GradeI) and purified human TGFβ1 were provided by Alomone Labs Ltd ...
Apaf-1, a human protein homologous to C. elegansCED-4, participates in cytochrome c-dependent activation of caspase-3
Supplier
Philpott Karen L. et al., In The Journal of Cell Biology, 1996
... NGF by rinsing twice in media without NGF and incubating the cells with 100 ng/ml anti-NGF antibody (GIBCO BRL; Life Technologies, Rockville, MD) ...
Intrinsic and extrinsic pathway signaling during neuronal apoptosis
Supplier
Johnson Eugene M. et al., In The Journal of Cell Biology, 1996
... Medium lacking NGF (AM0) consisted of Eagle's MEM with Earle's salts (Life Technologies) supplemented with 10% fetal ...
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation
Supplier
Miller Freda D. et al., In The Journal of Cell Biology, 1996
... NGF for these experiments was purified from mouse salivary glands (Cedarlane Labs ...
Substance P- and calcitonin gene-related peptide-immunofluorescent nerves in the repair of experimental bone defects
Supplier
Wilson Deborah et al., In Rheumatology (Oxford, England), 1993
... Rabbit polyclonal anti-PDGF (H55), anti-VEGF (A20) and anti-NGF (H-20) were from Santa Cruz Biotechnology, Inc ...
Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
Supplier
Miller Freda D. et al., In The Journal of Cell Biology, 1991
... NGF for these experiments was purified from mouse salivary glands (CedarLane, Hornby, ON) ...
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