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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear transcription factor, X-box binding 1

NFX1, transcription factor X-box binding protein 1, NFX-2
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: XBP1, CAN, V1a, UBE3A, Ubiquitin
Papers on NFX1
XBP1 Regulates the Biosynthetic Capacity of the Mammary Gland During Lactation by Controlling Epithelial Expansion and Endoplasmic Reticulum Formation.
New
Boisclair et al., Suzhou, China. In Endocrinology, Jan 2016
The coordination of synthesis and export of products in other secretory cells is orchestrated in part by the transcription factor X-box binding protein 1 (XBP1).
The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development.
New
Garrido et al., Dijon, France. In Oncogene, Oct 2015
At the intestine level, the drug promotes the splicing of the transcription factor X-box binding protein 1 (XBP1), which is a key component of the ER stress.
Gene expression in hepatocellular carcinoma: pilot study of potential transarterial chemoembolization response biomarkers.
New
Casadaban et al., Chicago, United States. In J Vasc Interv Radiol, May 2015
fold) pretreatment chemotherapy-sensitivity and mitosis (ATF4, BAX, CCNE1, KIF11, NFX1, PPP3CA, SNX1, TOP2A, and TOP2B) gene mRNA expression compared with tumors with PR, in addition to lower CXCL10 levels (0.48-fold), and had significantly (P < .05)
Human papillomavirus 16E6 and NFX1-123 potentiate Notch signaling and differentiation without activating cellular arrest.
New
Katzenellenbogen et al., Seattle, United States. In Virology, Apr 2015
HR HPV16 E6 (16E6) interacts with the cellular protein NFX1-123, and they collaboratively increase the growth and differentiation master regulator, Notch1.
Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation.
Antoniou et al., London, United Kingdom. In Arthritis Rheumatol, 2014
EDEM1, the UPR-associated transcription factor X-box binding protein 1 (XBP-1), the E3 ubiquitin ligase hydroxymethylglutaryl-coenzyme A reductase degradation 1 (HRD1), and the degradation-associated proteins derlin 1 and derlin 2 were inhibited using either short hairpin RNA or dominant-negative mutants.
Oxytocin modulates markers of the unfolded protein response in Caco2BB gut cells.
Welch et al., New York City, United States. In Cell Stress Chaperones, 2014
Both high and low OT activated inositol requiring enzyme1 (IRE1), which generates the transcription factor X-box binding protein 1 (XBP1) and induces the UPR.
The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease.
Cherrington et al., In Toxicol Sci, 2014
Protein expression of the adaptive liver response protein STC2 and the transcription factor X-box binding protein 1 spliced (XBP-1s) were significantly elevated among NASH samples, whereas other downstream ER stress proteins including CHOP, ATF4, and phosphorylated JNK and eIF2α were not significantly changed in disease progression.
NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
Katzenellenbogen et al., Seattle, United States. In J Virol, 2013
HR HPV16 E6 (16E6) interacts with the cellular protein NFX1-123, and together they posttranscriptionally increase hTERT expression, the catalytic subunit of telomerase.
Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Meier et al., Tübingen, Germany. In Sci Signal, 2013
Consistent with an ER stress-induced response, vemurafenib decreased the abundance of the ER chaperone protein glucose-regulated protein 78, increased the abundance of the spliced isoform of the transcription factor X-box binding protein 1 (XBP1) (which transcriptionally activates genes involved in ER stress responses), increased the phosphorylation of the translation initiation factor eIF2α (which would be expected to inhibit protein synthesis), and induced the expression of ER stress-related genes.
High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency.
Nutt et al., Australia. In J Immunol, 2012
The transcription factor X-box binding protein 1 (XBP-1) is an essential part of one of the branches of the unfolded protein response (UPR).
XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHOP.
Liu et al., Chongqing, China. In Histochem Cell Biol, 2012
The mammalian unfolded protein response (UPR) protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER), and the transcription factor X-box binding protein 1 spliced (XBP1S), a regulator of the UPR, is known to be important for ER stress (ERS)-mediated apoptosis and cell growth, but the molecular mechanism underlying these processes remains unexplored.
NFXL2 modifies cuticle properties in Arabidopsis.
Müssig et al., Potsdam, Germany. In Plant Signal Behav, 2012
Loss of the Arabidopsis NFX1-LIKE2 (NFXL2) gene (At5g05660) results in elevated ABA levels, elevated hydrogen peroxide levels, reduced stomatal aperture, and enhanced drought stress tolerance.
A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation.
Hatzoglou et al., Cleveland, United States. In Mol Cell Biol, 2012
Two key mediators of the UPR are PKR-like ER kinase (PERK), which phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2α), resulting in decreased protein synthesis, and the α subunit of inositol-requiring enzyme 1 (IRE1α), which initiates cytoplasmic splicing of the mRNA encoding the transcription factor X-box binding protein 1 (XBP1).
NFX1 plays a role in human papillomavirus type 16 E6 activation of NFkappaB activity.
GeneRIF
Galloway et al., Seattle, United States. In J Virol, 2010
a mechanism for HPV16 E6 activation of the NFkappaB pathway through NFX1-91
Structure and putative function of NFX1-like proteins in plants.
Review
Lisso et al., Potsdam, Germany. In Plant Biol (stuttg), 2010
The human NFX1 transcription factor constitutes a group of NFX1-type zinc finger proteins.
NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.
GeneRIF
Galloway et al., Seattle, United States. In J Virol, 2009
NFX1-123 is a cytoplasmic protein that colocalizes with poly(A) binding proteins, and binds hTERT mRNA in HPV16 E6-expressing keratinocytes.
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
GeneRIF
Galloway et al., Seattle, United States. In Mol Cell Biol, 2008
These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription.
NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
GeneRIF
Galloway et al., Seattle, United States. In J Virol, 2007
data suggest that NFX1-123 is integral to hTERT regulation in HPV16 E6-expressing epithelial cells and that the interaction between NFX1-123 and poly(A) binding proteins is critical to hTERT activity
Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function.
GeneRIF
Chan et al., Irvine, United States. In J Biol Chem, 2006
Nrf1 is normally targeted to the endoplasmic reticulum membrane and endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.
Impact
Glimcher et al., Boston, United States. In Nat Immunol, 2003
The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR).
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