Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.
New York City, United States. In Nature, 2010
We show that in vitro-derived cardiomyocytes from LEOPARD syndrome iPSCs are larger, have a higher degree of sarcomeric organization and preferential localization of NFATC4 in the nucleus when compared with cardiomyocytes derived from human embryonic stem cells or wild-type iPSCs derived from a healthy brother of one of the LEOPARD syndrome patients.
The role of NF-AT transcription factors in T cell activation and differentiation.
Würzburg, Germany. In Biochim Biophys Acta, 2000
The family of genuine NF-AT transcription factors consists of four members (NF-AT1 [or NF-ATp], NF-AT2 [or NF-ATc], NF-AT3 and NF-AT4 [or NF-ATx]) which are characterized by a highly conserved DNA binding domain (is designated as Rel similarity domain) and a calcineurin binding domain.
Control of cardiac myosin heavy chain gene expression.
Tucson, United States. In Microsc Res Tech, 2000
The beta-MHC gene also is induced together with several other "fetal" genes during cardiac hypertrophy by a mechanism involving Ca(2+)-mediated activation of calcineurin and NF-AT3.