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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Papers on NFATc3
Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element.
White et al., Philadelphia, United States. In Virology, 2012
The authors report that NFAT4 and NF-kappaB interact at the KB element to co-operatively activate both human polyomavirus JC early and late transcription and viral DNA replication.
GnRH regulation of Jun and Atf3 requires calcium, calcineurin, and NFAT.
Nilson et al., Pullman, United States. In Mol Endocrinol, 2012
Data suggest that NFAT4 is required for maximal accumulation of mRNA for proto-oncogenes c-Jun/c-Fos and Atf3 (activating transcription factor 3) in gonadotropes in response to (GnRH) gonadotropin-releasing hormone.
NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice.
Bosc et al., Albuquerque, United States. In Am J Physiol Lung Cell Mol Physiol, 2011
NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice
NFATc3 regulates the transcription of genes involved in T-cell activation and angiogenesis.
Redondo et al., Madrid, Spain. In Blood, 2011
NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation and NFATc3 regulates COX2 in endothelial cells
Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophy.
Kerppola et al., Ann Arbor, United States. In Mol Cell Biol, 2011
These data suggest that the opposing transcriptional activities of FoxP1 and Nfat3 maintain cardiomyocyte homeostasis.
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