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proteins. Page last changed on 08 Dec 2016.
Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATc3, NFAT4, NFATx
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010] (from
Nilson et al., Pullman, United States. In Mol Endocrinol, 2012
Data suggest that NFAT4 is required for maximal accumulation of mRNA for proto-oncogenes c-Jun/c-Fos and Atf3 (activating transcription factor 3) in gonadotropes in response to (GnRH) gonadotropin-releasing hormone.