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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Fos, ACID, CAN, p38
Papers using NFATC antibodies
Osteoclast differentiation and gene regulation
Kim Jeong-Joong et al., In Anatomy & Cell Biology, 2006
... Antibodies against c-Fos and NFATc1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth
Kim H-R C et al., In Oncogene, 2006
... NFATc1 antibodies for immunoblot analysis and immunofluorescence were purchased from BD Biosciences (Franklin Lakes, NJ, USA) ...
The role of T lymphocytes in bone metabolism
Lovibond A.C. et al., In Biochemical and Biophysical Research Communications, 2004
... Anti-NFATc1 antibody was obtained from Santa Cruz Biotechnology.
Insulin secretory deficiency and glucose intolerance in Rab3A null mice
Rhodes Christopher J. et al., In Diabetes, 2002
... Antibody to NFATc1 was purchased from BD Biosciences PharMingen (San Jose, CA) ...
Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers
Schneider Martin F. et al., In The Journal of Cell Biology, 1998
... two constructs have the FLAG epitope tag 5′ to the second codon of the human NFATc cDNA.The plasmids of NFATc–GFP fusion proteins were constructed in pEGFP-N1 (CLONTECH Laboratories, Inc.), with the ...
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Papers on NFATC
Sialoglycoproteins prepared from the eggs of Carassius auratus prevent bone loss by inhibiting the NF-κB pathway in ovariectomized rats.
Xue et al., Qingdao, China. In Food Funct, Feb 2016
Further research suggested that NF-κB signaling pathways were inhibited by suppressing the mRNA and protein expressions of NFATc1 and TRAF6, diminishing the mRNA expression and phosphorylation of NF-κB p65, three key transcription factors in NF-κB pathways.
Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function via Inhibition of NFATc1 Activity.
Xu et al., Nanning, China. In J Cell Physiol, Feb 2016
UNASSIGNED: RANKL induces differentiation and function of osteoclasts through triggering multiple signaling cascades, including NF-κB, MAPK, and Ca(2+) -dependent signals, which induce and activate critical transcription factor NFATc1.
The role of osteoclast differentiation and function in skeletal homeostasis.
Takeshita et al., Ōbu, Japan. In J Biochem, Jan 2016
Osteoclast biology shares many features and components with cells of the immune system, including cytokine-receptor interactions (RANKL-RANK), intracellular signalling molecules (TRAF6) and transcription factors (NFATc1).
Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage.
Sawalha et al., Ann Arbor, United States. In Arthritis Rheumatol, Jan 2016
We found differential DNA methylation of genes including the RNAi processing gene AGO2, the growth factor TGFβ3, the OA suppressor NFATC1, and the epigenetic effector HDAC4.
Salicortin inhibits osteoclast differentiation and bone resorption by down-regulating JNK and NF-κB/NFATc1 signaling pathways.
Yu et al., Beijing, China. In Biochem Biophys Res Commun, Jan 2016
Salicortin inhibited RANKL-induced c-Jun N-terminal kinase and NF-κB activation, concomitant with retarded IκBα phosphorylation and inhibition of p65 nuclear translocation, leading to impaired transcription of nuclear factor of activated T cells c1 (NFATc1) and expression of osteoclastic-specific genes.
NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor.
Won et al., Taejŏn, South Korea. In Data Brief, Dec 2015
We cloned the DDIAS promoter region and identified NFAT2 as a major transcription factor (Im et al., 2016 [1]).
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption.
Wan et al., Dallas, United States. In Cell Metab, Dec 2015
Mechanistically, IGFBP1 functions via its RGD domain to bind to its receptor integrin β1 on osteoclast precursors, thereby potentiating RANKL-stimulated Erk-phosphorylation and NFATc1 activation.
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
Pap et al., Münster, Germany. In Nat Med, Sep 2015
Myostatin strongly accelerates receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast formation in vitro through transcription factor SMAD2-dependent regulation of nuclear factor of activated T-cells (NFATC1).
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
Erler et al., Copenhagen, Denmark. In Nature, Jul 2015
We identify LOX as a novel regulator of NFATc1-driven osteoclastogenesis, independent of RANK ligand, which disrupts normal bone homeostasis leading to the formation of focal pre-metastatic lesions.
Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.
Haak et al., Amsterdam, Netherlands. In Prenat Diagn, Jun 2015
Fifteen candidate genes involved in both cardiac and lymphatic development were identified: Adrenomedullin; Chicken ovalbumin upstream promoter-transcription factor 2 (COUP-TFII); Cyp51; Ephrin-B2; Forkhead box protein C2 (Foxc2); Nuclear factor of activated T cells, cytoplasmic 1 (Nfatc1); Neurofibromatosis type 1 (Nf1); Phosphoinositide 3-kinase encoding isoform p110α (Pik3ca); Podoplanin; Prospero-related homeobox 1 (Prox1); T-box 1 (Tbx1); Tyrosine kinase with immunoglobulin-like and endothelial growth factor-like domains 1 (Tie1); vascular endothelial growth factor (Vegf)-A; Vegf receptor-3 (Vegfr-3); and Vascular endothelial zinc finger 1 (Vezf1).
NF-κB-Mediated Regulation of Osteoclastogenesis.
Yao et al., Rochester, United States. In Endocrinol Metab (seoul), Apr 2015
These studies have revealed that RANKL and some pro-inflammatory cytokines, including tumor necrosis factor, activate NF-κB and downstream signaling, including c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), and inhibition of repressors of NFATc1 signaling, to positively regulate osteoclast formation and functions.
mAKAP-a master scaffold for cardiac remodeling.
Kapiloff et al., Farmington, United States. In J Cardiovasc Pharmacol, Mar 2015
The main function of mAKAPβ signalosomes is to modulate stress-related gene expression regulated by the transcription factors NFATc, MEF2, and HIF-1α and type II histone deacetylases that control pathological cardiac hypertrophy.
Regulation of NFATc1 in Osteoclast Differentiation.
Kim et al., Kwangju, South Korea. In J Bone Metab, 2014
Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-κB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation.
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Kim et al., Boston, United States. In Cell, 2014
Gain- and loss-of-function experiments showed that BMP4-Bmpr1a signaling triggers calcineurin/NFATc1-dependent expression of thrombospondin-1 (Tsp1) in lung endothelial cells to drive alveolar lineage-specific BASC differentiation.
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.
Choi et al., Philadelphia, United States. In Cell Metab, 2013
Osteoclast maturation and function primarily depend on receptor activator of NF-κB ligand (RANKL)-mediated induction of nuclear factor of activated T cells c1 (NFATc1), which is further activated via increased intracellular calcium ([Ca(2+)](i)) oscillation.
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
Wakabayashi et al., Suita, Japan. In Mol Cell Biol, 2012
NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
Paxillin phosphorylation by JNK and p38 is required for NFAT activation.
Lai et al., Taipei, Taiwan. In Eur J Immunol, 2012
results demonstrate that dual phosphorylation of paxillin by JNK and p38 MAPK is essential for T-cell activation and suggest that NFAT is a functional target of the JNK/p38 phosphorylated paxillin
Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT.
Kim et al., Stanford, United States. In Dev Cell, 2012
Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion.
Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein.
Mikoshiba et al., Tokyo, Japan. In Mol Cell Biol, 2012
Cot activity in osteoclasts was enhanced via cell-cell interaction with osteoblasts, and Cot promoted Ca(2+) oscillation/calcineurin-independent osteoclastogenesis by increasing NFATc1 stability through phosphorylation.
NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells.
Hiroi et al., Tokyo, Japan. In Int Arch Allergy Immunol, 2011
NFAT1 and NFAT2 facilitated IL-17A expression in human T cells, though distinct mechanisms might be involved in these effects
More papers using NFATC antibodies
T cell activation leads to rapid stimulation of eIF2B and inactivation of glycogen synthase kinase 3
Cantrell Doreen A. et al., In The Journal of Experimental Medicine, 1995
... The full-length NFATC1 cDNA was subcloned into the pEGFP-C1 vector (Clontech ...
Selective antagonism by PPADS at P2X-purinoceptors in rabbit isolated blood vessels
Yamada Yoshihiko et al., In The Journal of Cell Biology, 1993
... obtained from Cell Signaling Technology; Rb, P-NFATc1, and MDM2 were from Santa Cruz Biotechnology, Inc.; NFATc1 was from BD; α-tubulin from Sigma-Aldrich; Ocn from Biomedical Technology; and calnexin from ...
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