The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Los Angeles, United States. In Immunity, Mar 2015
When expressed in cells, an engineered form of NFAT1 unable to interact with AP-1 transcription factors diminished T cell receptor (TCR) signaling, increased the expression of inhibitory cell surface receptors, and interfered with the ability of CD8(+) T cells to protect against Listeria infection and attenuate tumor growth in vivo.
Architecture and expression of the nfatc1 gene in lymphocytes.
Würzburg, Germany. In Front Immunol, 2013
In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca(++), the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc proteins.
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Padova, Italy. In J Neuroinflammation, 2011
Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1.