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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Interleukin-2, AP-1, IL-4, CD4
Papers on NFAT1
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
Augustin et al., Heidelberg, Germany. In Dev Cell, Feb 2016
RNF213 targets filamin A and NFAT1 for proteasomal degradation attenuating non-canonical WNT/Ca(2+) signaling.
How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?
Zhou, Bethesda, United States. In World J Nephrol, Feb 2016
Cyclosporine A and tacrolimus suppress immune reactions by inhibiting the phosphatase calcineurin-dependent activation of NFAT1.
Increased Wnt Signaling and Reduced Viability in a Neuronal Model of Progranulin-Deficient Frontotemporal Lobar Degeneration.
Martín-Requero et al., Madrid, Spain. In Mol Neurobiol, Jan 2016
We detected increased expression levels of Wnt1 and Wnt5a ligands of the Frizzled receptors, as well as evidence for increased signaling of the Wnt/β-catenin and Wnt/Ca(2+) cascades in PGRN deficient cells, such as increased nuclear content of β-catenin and higher levels of cyclin D1, or increased levels of the active form of the NFAT1 transcription factor, respectively.
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Im et al., Kwangju, South Korea. In Sci Rep, Dec 2015
In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity.
Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses.
Lai et al., Taiwan. In Immunol Res, Dec 2015
LOC100506036 could regulate the expression of SMPD1 and NFAT1 and could contribute to the inflammatory responses in RA.
Cell-based articular cartilage repair: the link between development and regeneration.
Wang et al., Kansas City, United States. In Osteoarthritis Cartilage, Mar 2015
The recent finding that NFAT1 and NFAT2 transcription factors (TFs) inhibit chondrocyte hypertrophy and maintain metabolic balance in AC is a significant advance in the field of AC repair.
The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
Rao et al., Los Angeles, United States. In Immunity, Mar 2015
When expressed in cells, an engineered form of NFAT1 unable to interact with AP-1 transcription factors diminished T cell receptor (TCR) signaling, increased the expression of inhibitory cell surface receptors, and interfered with the ability of CD8(+) T cells to protect against Listeria infection and attenuate tumor growth in vivo.
Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties.
Du et al., Wuhan, China. In Sci Rep, 2014
The activities of NFAT1 and NF-κB p65/50 were down-regulated by Lovastatin, too.
Architecture and expression of the nfatc1 gene in lymphocytes.
Serfling et al., Würzburg, Germany. In Front Immunol, 2013
In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca(++), the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc proteins.
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Weigmann et al., Switzerland. In Cancer Res, 2012
our findings highlight a pivotal role for NFATc2 in the establishment of inflammation-associated colorectal tumors mediated by control of IL-6 expression.
Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
Zhang et al., Amarillo, United States. In J Biol Chem, 2012
Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation.
Im et al., Kwangju, South Korea. In J Biol Chem, 2012
Data suggest that functional cooperation of NFAT1 and NF-kappaB (p65) synergistically enhances IL-9 transcription in CD4(+) T cells.
Differences in MEF2 and NFAT transcriptional pathways according to human heart failure aetiology.
Portolés et al., Valencia, Spain. In Plos One, 2011
The present study investigated the effect of heart failure aetiology on Ca(+2) handling proteins and NFAT1, MEF2C and GATA4 (transcription factors) in the same cardiac tissue.
NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells.
Hiroi et al., Tokyo, Japan. In Int Arch Allergy Immunol, 2011
NFAT1 and NFAT2 facilitated IL-17A expression in human T cells, though distinct mechanisms might be involved in these effects
Parkinson's disease and immune system: is the culprit LRRKing in the periphery?
Bubacco et al., Padova, Italy. In J Neuroinflammation, 2011
Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon γ, and its function as negative regulator of the immune response transcription factor NFAT1.
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Lenardo et al., Bethesda, United States. In Nat Immunol, 2011
Furthermore, the risk-associated allele encoding LRRK2 Met2397 identified by a genome-wide association study for Crohn's disease resulted in less LRRK2 protein post-translationally. Severe colitis in LRRK2-deficient mice was associated with enhanced nuclear localization of NFAT1.
Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells.
Chen et al., Boston, United States. In Immunity, 2011
We have solved the crystal structure of the FOXP3 forkhead domain as a ternary complex with the DNA-binding domain of the transcription factor NFAT1 and a DNA oligonucleotide from the interleukin-2 promoter.
Molecular regulation of articular chondrocyte function and its significance in osteoarthritis.
Wang et al., Kansas City, United States. In Histol Histopathol, 2011
Recent studies have discovered that transcription factor Nfat1 may play an important role in maintaining the physiological function of adult articular chondrocytes.
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.
Michelakis et al., Edmonton, Canada. In Cancer Cell, 2007
Dichloroacetate (DCA) inhibits mitochondrial pyruvate dehydrogenase kinase (PDK), shifts metabolism from glycolysis to glucose oxidation, decreases DeltaPsim, increases mitochondrial H2O2, and activates Kv channels in all cancer, but not normal, cells; DCA upregulates Kv1.5 by an NFAT1-dependent mechanism.
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.
Rao et al., Boston, United States. In Nature, 2006
Precise regulation of the NFAT (nuclear factor of activated T cells) family of transcription factors (NFAT1-4) is essential for vertebrate development and function.
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