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Interleukin enhancer binding factor 3, 90kDa

NF90, ILF3, MPP4, interleukin enhancer binding factor 3
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] (from NCBI)
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Top mentioned proteins: NF45, CAN, fibrillin-1, V1a, ACID
Papers using NF90 antibodies
Identification of a phorbol ester-responsive element in the interferon-gamma receptor 1 chain gene
Supplier
Bai Yidong, In PLoS ONE, 2000
... To generate NF90 transgenic mice, mouse NF90 (mNF90) ...
Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins
Supplier
Macara Ian G. et al., In The Journal of Cell Biology, 1997
... ILF3 was cloned into pKH3 and pEGFP-C2 (CLONTECH Laboratories, Inc.) ...
Papers on NF90
The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells.
New
Wu et al., Shantou, China. In Int J Oncol, Jan 2016
The co-expression network of MEG3 was generated by GO analysis and ILF3 was identified as MEG3 binding protein by RNA pulldown and western blot analysis.
Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.
New
Cook et al., Edinburgh, United Kingdom. In Nucleic Acids Res, Jan 2016
UNASSIGNED: Nuclear factors 90 and 45 (NF90 and NF45) form a protein complex involved in the post-transcriptional control of many genes in vertebrates.
Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation.
New
Mao et al., Beijing, China. In J Biol Chem, Jan 2016
Furthermore, we found that SALNR interacts with NF90 (nuclear factor of activated T-cells, 90 kDa), an RNA-binding protein suppressing miRNA biogenesis.
Enhanced diagnostic yield in Meckel-Gruber and Joubert syndrome through exome sequencing supplemented with split-read mapping.
New
Bonthron et al., Leeds, United Kingdom. In Bmc Med Genet, Dec 2015
These analyses identified a putative intragenic AHI1 deletion that included three exons spanning at least 3.4 kb and an intergenic MPP4 to TMEM237 deletion that included exons spanning at least 21.5 kb.
SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.
New
Griffin et al., Jupiter, United States. In J Proteome Res, Dec 2015
SERBP1 and ILF3 were identified as LRH1 interacting partners by both Western blot and MS/MS analysis.
Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.
New
Wellmann et al., Basel, Switzerland. In Faseb J, Nov 2015
However, based on affinity purification coupled with mass spectrometry, coimmunoprecipitation, and proximity ligation assay, we revealed that nuclear factor 90 (NF90) is a novel protein interactor of PERK and that this interaction is essential for RBM3-mediated regulation of PERK activity, which requires an RNA-dependent interaction.
Fouling characteristics and cleaning strategies of NF membranes for the advanced treatment of antibiotic production wastewater.
New
Wei et al., Beijing, China. In Environ Sci Pollut Res Int, Oct 2015
UNASSIGNED: The nanofiltration (NF) membrane fouling characteristics and cleaning strategies were investigated through a laboratory-scale NF fouling test treating membrane bioreactor (MBR) effluent and MBR-granular activated carbon (GAC) effluent of an antibiotic production wastewater by DK and NF90 membranes, respectively.
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.
New
Impact
Passegué et al., San Francisco, United States. In Cell Stem Cell, Aug 2015
Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production.
Ilf3 and NF90 functions in RNA biology.
Review
New
Larcher et al., Paris, France. In Wiley Interdiscip Rev Rna, Mar 2015
Among these DRBPs, Interleukin enhancer-binding factor 3 (Ilf3) and Nuclear Factor 90 (NF90) are two ubiquitous proteins generated by mutually exclusive and alternative splicings of the Ilf3 gene.
NF90 isoforms, a new family of cellular proteins involved in viral replication?
Review
Urcuqui-Inchima et al., Medellín, Colombia. In Biochimie, 2015
Due to various potential translational events such as alternative splicing, the human Interleukin enhancer binding factor 3 (ilf3) gene codes for multifunctional proteins that are NF90 and its isoforms, involved in transcription, translation, mRNA export and microRNA biogenesis.
RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.
Greally et al., United States. In Epigenetics Chromatin, 2014
Mass spectrometry studies of chromatin at RNA:DNA hybrids shows the presence of the ILF2 and ILF3 transcription factors, supporting a model of certain transcription factors binding preferentially to the RNA:DNA conformation.
The construction of cDNA library and the screening of related antigen of ascitic tumor cells of ovarian cancer.
Shan et al., In Eur J Gynaecol Oncol, 2014
They were then divided into six categories: (1) the homologous genes which related to the known ovarian cancer genes, such as BARD 1 gene, etc; (2) the homologous genes which were associated with other tumors, such as TM4SFI gene, etc; (3) the genes which were expressed in a special organization, such as ILF3, FXR1 gene, etc; (4) the genes which were the same with some protein genes of special function, such as TIZ, ClD gene; (5) the homologous genes which possessed the same source with embryonic genes, such as PKHD1 gene, etc; (6) the remaining genes were the unknown genes without the homologous sequence in the gene pool, such as OV-189 genes.
The presence, role and clinical use of spermatozoal RNAs.
Review
Reproductive Medicine Network et al., Detroit, United States. In Hum Reprod Update, 2013
Other non-coding spermatozoal RNAs include transposable elements, annotated lnc-RNAs, intronic retained elements, exonic elements, chromatin-associated RNAs, small-nuclear ILF3/NF30 associated RNAs, quiescent RNAs, mse-tRNAs and YRNAs.
NF90 in posttranscriptional gene regulation and microRNA biogenesis.
Review
Imoto et al., Tokushima, Japan. In Int J Mol Sci, 2012
Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism.
Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivin.
GeneRIF
Furuichi et al., Tsukuba, Japan. In Mol Cell Proteomics, 2012
The unique C-terminal region of ILF3/NF110 is important for promoting survivin expression and for high affinity binding to YM155.
Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.
GeneRIF
Yu et al., Morgantown, United States. In Oncol Rep, 2012
high expression of ERCC1, XPB and ILF3 was observed in human epithelial ovarian cancer
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.
GeneRIF
Mathews et al., Newark, United States. In Mol Cell Biol, 2011
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining
DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function.
GeneRIF
Basler et al., New York City, United States. In J Infect Dis, 2011
These data suggest that DRBP76, via its association with VP35, exerts an anti-Ebola virus function.
L-Ilf3 and L-NF90 traffic to the nucleolus granular component: alternatively-spliced exon 3 encodes a nucleolar localization motif.
GeneRIF
Larcher et al., Paris, France. In Plos One, 2010
The protein polymorphism of Ilf3/NF90 and the various subcellular localizations of their isoforms may partially explain the various functions previously reported for these proteins.
snaR genes: recent descendants of Alu involved in the evolution of chorionic gonadotropins.
Review
Mathews et al., Newark, United States. In Cold Spring Harb Symp Quant Biol, 2008
We identified a novel family of human noncoding RNAs by in vivo cross-linking to the nuclear factor 90 (NF90) protein.
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