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Interleukin enhancer binding factor 2, 45kDa

NF45, ILF2
Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NF90, Interleukin-2, fibrillin-1, CAN, ACID
Papers on NF45
Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.
New
Cook et al., Edinburgh, United Kingdom. In Nucleic Acids Res, Jan 2016
UNASSIGNED: Nuclear factors 90 and 45 (NF90 and NF45) form a protein complex involved in the post-transcriptional control of many genes in vertebrates.
NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma.
New
Zhang et al., Nantong, China. In Mol Cell Biochem, Dec 2015
NF45, also referred to as nuclear factor of activated T cells, has been reported to promote the progression of multiple cancer types.
NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury.
New
Shi et al., Nantong, China. In Pathol Res Pract, Dec 2015
There is accumulating evidence that nuclear factor 45 (NF45) and regulatory pathways are important in understanding reparative processes in the myocardium.
The RNA Binding Complexes NF45-NF90 and NF45-NF110 Associate Dynamically with the c-fos Gene and Function as Transcriptional Coactivators.
New
Hisatake et al., Tsukuba, Japan. In J Biol Chem, Nov 2015
We report here that NF45-NF90 and NF45-NF110, which possess archetypical double-stranded RNA binding motifs, have a direct function as transcriptional coactivators.
Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis.
New
Ji et al., Nantong, China. In J Mol Histol, Oct 2015
ILF2 (NF45) is a sequence-specific DNA binding protein that is involved in mitosis control, transcriptional regulation, DNA breaks repair, microRNA processing and viral replication.
The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.
New
Kutay et al., Zürich, Switzerland. In Mol Cell Biol, Oct 2015
The interleukin enhancer binding factors ILF2 (NF45) and ILF3 (NF90/NF110) have been implicated in various cellular pathways, such as transcription, microRNA (miRNA) processing, DNA repair, and translation, in mammalian cells.
Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.
New
Sakamoto et al., Kōchi, Japan. In Mol Cell Biol, Jul 2015
The nuclear factor 90 (NF90)-NF45 complex is known as a negative regulator in miRNA biogenesis.
Up-regulation of NF45 correlates with Schwann cell proliferation after sciatic nerve crush.
New
Zhang et al., Nantong, China. In J Mol Neurosci, May 2015
However, the role of NF45 in the process of peripheral nervous system regeneration after injury remains poorly understood.
Expression and clinical role of NF45 as a novel cell cycle protein in esophageal squamous cell carcinoma (ESCC).
New
Guo et al., Shanghai, China. In Tumour Biol, Feb 2015
NF45 (also known as ILF2), as one subunit of NF-AT (nuclear factor of activated T cells), repairs DNA breaks, inhibits viral replication, and also functions as a negative regulator in the microRNA processing pathway in combination with NF90.
Evaluation of 2'-Deoxy-2'-fluoro Antisense Oligonucleotides for Exon Skipping in Duchenne Muscular Dystrophy.
Aartsma-Rus et al., Leiden, Netherlands. In Mol Ther Nucleic Acids, 2014
The 2'-deoxy-2'-fluoro (2F) RNA modification is attractive for exon skipping due to its ability to recruit ILF2/3 proteins to the 2F/pre-mRNA duplex, which resulted in enhanced exon skipping in spinal muscular atrophy models.
RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.
Greally et al., United States. In Epigenetics Chromatin, 2014
Mass spectrometry studies of chromatin at RNA:DNA hybrids shows the presence of the ILF2 and ILF3 transcription factors, supporting a model of certain transcription factors binding preferentially to the RNA:DNA conformation.
Neurocysticercosis: the effectiveness of the cysticidal treatment could be influenced by the host immunity.
Fleury et al., Mexico. In Med Microbiol Immunol, 2014
The function of up-regulated genes exerted pro-inflammatory (RORγC, Sema4A, SLAMF3, SLAMF6), anti-inflammatory (TGFβ, TNFRSF25, TNFRS18, SLAMF1, ILF2), or immunomodulatory effects (CXCL2, RUNX3, SLAMF9, TGFBR3).
Expression of NF45 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth.
Wang et al., Nantong, China. In Tumour Biol, 2014
Nuclear factor of activated T cells 45 kDa (NF45), is a transcription factor that interacts with NF90 to regulate gene expression.
An integrated membrane system for the biocatalytic production of 3'-sialyllactose from dairy by-products.
Pinelo et al., Denmark. In Bioresour Technol, 2014
The lactose in the permeate could be concentrated by the NF45 membrane and recycled into the EMR.
RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45.
Nakayama et al., In J Biol Chem, 2014
Among the identified proteins, we focused on nuclear factor (NF) 45 and its binding partner, nuclear factor associated with dsRNA 2 (NFAR2), and we demonstrated that NF45 promotes disassembly of RNA granules, whereas NFAR2 enhances the assembly of RNA granules in cultured cells.
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.
GeneRIF
Mathews et al., Newark, United States. In Mol Cell Biol, 2011
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining
Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
GeneRIF
Wang et al., Zhengzhou, China. In J Proteome Res, 2011
spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection
A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus.
GeneRIF
Weissman et al., New Haven, United States. In Embo J, 2010
ILF2 recruits a DNA-associated replication and transcription complex, of which it is a part, to its target DNA sequence.
NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response.
GeneRIF
Holcik et al., Ottawa, Canada. In Cell Death Differ, 2010
The data presented are consistent with a model in which translation of cIAP1 is governed, at least in part, by NF45, a novel cellular IRES trans-acting factor.
NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells.
GeneRIF
Vercelli et al., Tucson, United States. In J Biol Chem, 2010
our results identify NF45 and NF90 as novel regulators of HS4-dependent human IL13 transcription in response to T cell activation
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