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Neurofilament, light polypeptide

NF-L, NEFL, NF68
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: INa, NF-H, CAN, HAD, Glial Fibrillary Acidic Protein
Papers using NF-L antibodies
Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments
Supplier
Julien Jean-Pierre et al., In The Journal of Cell Biology, 1996
... Mice carrying the transgenes in NF-L null background were obtained by breeding transgenic mice with NF-L knockout ...
Papers on NF-L
NO FLOWERING IN SHORT DAY (NFL) is a bHLH transcription factor that promotes flowering specifically under short-day in Arabidopsis.
New
Huq et al., Austin, United States. In Development, Feb 2016
Here we identified a critical basic Helix-Loop-Helix transcription factor called NFL (NO FLOWERING IN SHORT DAY) that is essential to induce flowering specifically under SD conditions in Arabidopsis.
Acrylamide Retards the Slow Axonal Transport of Neurofilaments in Rat Cultured Dorsal Root Ganglia Neurons and the Corresponding Mechanisms.
New
Xie et al., Jinan, China. In Neurochem Res, Jan 2016
Furthermore, ACR intoxication significantly increases the protein levels of the three neurofilament subunits (NF-L, NF-M, NF-H), kinesin, dynein, and dynamitin subunit of dynactin in DRG neurons.
Structure-guided redesign increases the propensity of HIV Env to generate highly stable soluble trimers.
New
Wyatt et al., Los Angeles, United States. In J Virol, Jan 2016
Soluble Env mimetics, like the NFL (native flexibly linked) and SOSIP trimers, derived from the subtype A BG505 Env, form homogeneous, stable native-like trimers.
Promoting effect of small molecules in cardiomyogenic and neurogenic differentiation of rat bone marrow-derived mesenchymal stem cells.
New
Mohan et al., Kuala Lumpur, Malaysia. In Drug Des Devel Ther, Dec 2015
The mRNA expression of neuronal-specific markers, Map2, Nefl, Tau, and Nestin, was significantly higher, indicating that the treated cells differentiated into neuronal-like cells.
Blast overpressure induced axonal injury changes in rat brainstem and spinal cord.
New
Cavanaugh et al., Detroit, United States. In J Neurosci Rural Pract, Oct 2015
MATERIALS AND METHODS: Sagittal brainstem sections and horizontal cervical spinal cord sections from blast and sham animals were stained by neurofilament light (NF-L) chain and beta amyloid precursor protein immunocytochemistry and observed for axonal injury changes.
Cerebral Toxocariasis: Silent Progression to Neurodegenerative Disorders?
Review
New
Barghouth et al., Taipei, Taiwan. In Clin Microbiol Rev, Jul 2015
Recent data describe an enhanced expression of biomarkers associated with brain injury, such as GFAP, AβPP, transforming growth factor β1 (TGF-β1), NF-L, S100B, tTG, and p-tau, in mice receiving even low doses of Toxocara ova.
Mitochondrial dynamics and inherited peripheral nerve diseases.
Review
New
Piscosquito et al., Milano, Italy. In Neurosci Lett, Jul 2015
Microtubules, neurofilaments, and chaperones such as heat shock proteins (HSPs) also have a fundamental role in mitochondrial transport and mutations in some of related encoding genes cause peripheral neuropathy (TUBB3, NEFL, HSPB1, HSPB8, HSPB3, DNAJB2).
Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons.
Impact
Zhang et al., Wuhan, China. In Cell Stem Cell, 2014
These changes were associated with decreased stability of NF-L mRNA and binding of its 3' UTR by mutant SOD1 and thus altered protein proportion of NF subunits.
Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease.
Review
Agúndez et al., Madrid, Spain. In Front Cell Neurosci, 2013
The most consistent findings are: (a) the possible role of CSF urate on the progression of the disease; (b) the possible relations of CSF total tau and phosphotau protein with the progression of PD and with the preservation of cognitive function in PD patients; (c) the possible value of CSF beta-amyloid 1-42 as a useful marker of further cognitive decline in PD patients, and (d) the potential usefulness of CSF neurofilament (NFL) protein levels in the differential diagnosis between PD and other parkinsonian syndromes.
Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?
Review
Petratos et al., In Acta Neuropathol Commun, 2013
Greater accuracy of predictive biomarkers is therefore warranted and may include CSF neurofilament light chain (NF-L) and neurofilament heavy chain (NF-H) levels, for progressive MS.
Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants.
GeneRIF
Blennow et al., United States. In Exp Gerontol, 2012
Subjects with APOE epsilon4 have higher CSF NFL levels than non-epsilon4 carriers, only when they do not carry a short poly-T variant of TOMM40, which is associated with later age of onset of AD.
Expressing hNF-LE397K results in abnormal gaiting in a transgenic model of CMT2E.
GeneRIF
Garcia et al., Columbia, United States. In Genes Brain Behav, 2012
Identification of gaiting defects combined with previously observed muscle atrophy, reduced axon caliber, and decreased nerve conduction velocity suggests that hNF-L(E397K) mice recapitulate many clinical signs associated with Charcot-Marie-Tooth disease.
Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease.
GeneRIF
Durham et al., Montréal, Canada. In Faseb J, 2012
Data show that mitochondria essentially stopped moving in neurons expressing neurofilament protein (NFL) mutants, probably a consequence of cytoskeletal disruption.
Role of neurofilament light polypeptide in head and neck cancer chemoresistance.
GeneRIF
Guo et al., Bloomington, United States. In Mol Cancer Res, 2012
Neurofilament light polypeptide (NEFL) was identified as a novel hypermethylated gene associated with resistance to cisplatin-based chemotherapy in cancer of head and neck.
NEFL mRNA expression level is a prognostic factor for early-stage breast cancer patients.
GeneRIF
Feng et al., Tianjin, China. In Plos One, 2011
NEFL mRNA is ectopically expressed in breast malignancies and could be a potential prognostic factor for early-stage breast cancer patients
Gel-expanded to gel-condensed transition in neurofilament networks revealed by direct force measurements.
Impact
Safinya et al., Santa Barbara, United States. In Nat Mater, 2010
Neurofilaments (NF)--the principal cytoskeletal constituent of myelinated axons in vertebrates--consist of three molecular-weight subunit proteins NF-L (low), NF-M (medium) and NF-H (high), assembled to form mature filaments with protruding unstructured C-terminus side arms.
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.
Impact
Tsai et al., United States. In Nat Cell Biol, 2004
NUDEL facilitates the polymerization of NFs through a direct interaction with the NF light subunit (NF-L).
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Impact
Timmerman et al., New York City, United States. In Nat Genet, 2004
Cotransfection of neurofilament light chain (NEFL) and mutant HSPB1 resulted in altered neurofilament assembly in cells devoid of cytoplasmic intermediate filaments.
Primary cutaneous follicular lymphoma: an assessment of clinical, histopathologic, immunophenotypic, and molecular features.
Impact
Hsi et al., Cleveland, United States. In J Clin Oncol, 2002
PURPOSE: Unlike nodal follicular lymphoma (NFL), Primary cutaneous follicular lymphomas (PCFLs) rarely express Bcl-2 protein or t(14;18)(q32;q21) (Bcl-2/IgH).
The Problem of Neurodegeneration in Cumulative Sports Concussions: Emphasis on Neurofibrillary Tangle Formation
Review
Xu et al., Boca Raton, United States. In Unknown Journal, 0001
The problem of traumatic degeneration, termed chronic traumatic encephalopathy (CTE), has been long recognized in the world of boxing, but has recently come to the forefront because of several highly publicized deaths of popular NFL protagonists.
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