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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NF-kappaB, NF-kappaB,
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Papers using NF-kappaB antibodies
Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
Supplier
Waltz Susan E. et al., In Oncogene, 2005
... Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model ...
Papers on NF-kappaB
Chronic intermittent hypoxia induces atherosclerosis by NF-κB-dependent mechanisms.
GeneRIF
Liu et al., United States. In Biochim Biophys Acta, 2012
P50 gene deletion inhibited vascular wall inflammation, reduced hepatic TNF-alpha level, attenuated the elevation in serum cholesterol level and diminished macrophage foam cell formation induced by CIH+HCD exposure.
Leukotriene B(4) inhibits neutrophil apoptosis via NADPH oxidase activity: redox control of NF-κB pathway and mitochondrial stability.
GeneRIF
Arruda et al., Rio de Janeiro, Brazil. In Biochim Biophys Acta, 2012
NADPH oxidase-derived reactive oxygen species are critical to leukotriene B(4) pro-survival effect on neutrophils. This effect also relies on redox modulation of nuclear factor kappaB signaling pathway.
EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression.
GeneRIF
Baltimore et al., Kuala Lumpur, Malaysia. In J Biol Chem, 2012
EHMT1 protein binds to nuclear factor-kappaB p50 and represses gene expression.
Risk association between the NF-κB1 -94ins/delATTG promoter polymorphism and inflammatory bowel diseases: a meta-analysis.
GeneRIF
Lin et al., Nanjing, China. In Dig Dis Sci, 2012
This meta-analysis indicated that the NF-kappaB1 -94ins/delATTG promoter polymorphism is a risk factor for ulcerative colitis but not Crohn's disease.
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
Impact
GeneRIF
Ting et al., Chapel Hill, United States. In Nat Immunol, 2012
NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB by interacting with the TLR signaling adaptor TRAF6
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