Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Changchun, China. In Oxid Med Cell Longev, 2014
SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.
The chemical biology of naphthoquinones and its environmental implications.
Tsukuba, Japan. In Annu Rev Pharmacol Toxicol, 2011
The targets for these reactions include regulatory proteins such as protein tyrosine phosphatases; Kelch-like ECH-associated protein 1, the regulatory protein for NF-E2-related factor 2; and the glycolysis enzyme glyceraldehyde-3-phosphate dehydrogenase.