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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-maf musculoaponeurotic fibrosarcoma oncogene family, protein K

NF-E2, MafK
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] (from NCBI)
Top mentioned proteins: Nrf2, V1a, Ros, CAN, Keap1
Papers on NF-E2
Enhanced muscle nutrient content and flesh quality, resulting from tryptophan, is associated with anti-oxidative damage referred to the Nrf2 and TOR signalling factors in young grass carp (Ctenopharyngodon idella): Avoid tryptophan deficiency or excess.
Feng et al., Chengdu, China. In Food Chem, Jun 2016
The expression of signalling molecules [Kelch-like ECH-associated protein 1, target of rapamycin (TOR) and ribosomal S6 protein kinase 1] involved in the NF-E2-related factor 2 (Nrf2) pathway revealed a potential method of Trp-enhanced antioxidant defence.
Relationships among alcoholic liver disease, antioxidants, and antioxidant enzymes.
Fukushima et al., Obihiro, Japan. In World J Gastroenterol, Feb 2016
These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1-NF-E2-related factor-2 pathway and antioxidant responsive elements.
Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis.
Sudhandiran et al., Chennai, India. In Chem Biol Interact, Feb 2016
Celastrol also reduces inflammation in BLM-induced rats as evidenced by decrease in the expressions of mast cells, Tumor necrosis factor (TNF- α) and matrix metalloproteinases (MMPs) 2 and 9. Further, Western blot analysis shows that celastrol is a potent inducer of NF-E2-related factor 2 (Nrf2) and it restores the activities of Phase II enzymes such as hemoxygenase-1 (HO-1), glutathione-S-transferase (GSTs) and NADP(H): quinine oxidoreductase (NQO1) which were declined upon BLM administration.
The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation.
Wu et al., Fort Worth, United States. In Redox Biol, Jan 2016
UNASSIGNED: Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD).
NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies.
Deeni et al., Edinburgh, United Kingdom. In Oxid Med Cell Longev, Dec 2015
NF-E2 related factor-2 (NRF2) is an essential transcription factor for multiple genes encoding antioxidants and detoxification enzymes.
The complexity of the Nrf2 pathway: beyond the antioxidant response.
Kong et al., United States. In J Nutr Biochem, Dec 2015
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an efficient and pivotal line of defensive to counteract environmental insults and endogenous stressors.
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.
Wu et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
RESULT: ASC transplantation significantly improved the survival rate of mice with ALF and attenuated the severity of APAP-induced liver damage by suppressing cytochrome P450 activity to reduce the accumulation of toxic nitrotyrosine and the upregulation of NF-E2-related factor 2 (Nrf2) expression, resulting in an increase in the subsequent antioxidant activity.
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Sutherland et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
UNLABELLED: Nuclear factor-erythroid 2 p45 (NF-E2 p45)-related factor 2 (Nrf2) is a master regulator of redox homoeostasis that allows cells to adapt to oxidative stress and also promotes cell proliferation.
The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics.
Abramov et al., Irving, United States. In Biochem Soc Trans, Sep 2015
The Kelch-like ECH associated protein 1 (Keap1)-NF-E2 p45-related factor 2 (Nrf2) pathway regulates networks of proteins that protect against the cumulative damage of oxidants, electrophiles and misfolded proteins.
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.
Blackwell et al., Boston, United States. In Nature, Apr 2015
Here we show that rIIS can promote C. elegans longevity through a program that is genetically distinct from the dauer pathway, and requires the Nrf (NF-E2-related factor) orthologue SKN-1 acting in parallel to DAF-16.
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Zheng et al., Changchun, China. In Oxid Med Cell Longev, 2014
SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
MafF, MafG, and MafK triple-knockout mice developed normally until embryonic day 9.5 (E9.5). Thereafter, however, the triple-knockout embryos showed severe growth retardation and liver hypoplasia, and the embryos died around E13.5.
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression.
Röcken et al., Tübingen, Germany. In Nat Med, 2012
In endotoxin-stimulated monocytes, ROS stress strongly superinduced NF-E2-related factor 2 (NRF2)-dependent ATF3.
The chemical biology of naphthoquinones and its environmental implications.
Cho et al., Tsukuba, Japan. In Annu Rev Pharmacol Toxicol, 2011
The targets for these reactions include regulatory proteins such as protein tyrosine phosphatases; Kelch-like ECH-associated protein 1, the regulatory protein for NF-E2-related factor 2; and the glycolysis enzyme glyceraldehyde-3-phosphate dehydrogenase.
Sickle hemoglobin confers tolerance to Plasmodium infection.
Soares et al., Portugal. In Cell, 2011
Sickle Hb induces the expression of heme oxygenase-1 (HO-1) in hematopoietic cells, via a mechanism involving the transcription factor NF-E2-related factor 2 (Nrf2).
MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy.
Takahashi et al., Tsukuba, Japan. In Biochem Biophys Res Commun, 2009
Histological analysis revealed that embryonic development of beta cells in the MafA(-/-)MafK(+) mice was significantly suppressed and the reduced number of beta cells was responsible for the early onset of diabetes.
MafK/NF-E2 p18 is required for beta-globin genes activation by mediating the proximity of LCR and active beta-globin genes in MEL cell line.
Liang et al., Beijing, China. In Int J Biochem Cell Biol, 2007
MafK/NF-E2 p18 recruitment was involved in the physical proximity of LCR and active beta-globin genes upon beta-globin gene transcriptional activation.
Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis.
Nishihara et al., Suita, Japan. In Biochem J, 2007
during early hepatocarcinogenesis, aberrantly expressed MYST histone acetyltransferase 3 may induce glutathione S-transferase placental form expression through the Nrf2-mediated pathway
HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression.
Le Saux et al., Honolulu, United States. In Biochim Biophys Acta, 2006
The involvement of both HNF4alpha and NF-E2 in Abcc6 gene regulation suggests that Abcc6 might be involved in a detoxification processes related to hemoglobin or heme.
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element.
Pickett et al., United States. In Annu Rev Pharmacol Toxicol, 2002
This review focuses on the molecular mechanisms whereby the transcriptional activation mediated by the interaction between the ARE and NF-E2-related factor 2 (Nrf2) is regulated.
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