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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lipocalin 2

neutrophil gelatinase-associated lipocalin, NGAL, lipocalin 2, Lcn2, 24p3
mouse homolog plays a role in IL3 withdrawal-induced apoptosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: lipocalin, MMP-9, HAD, CAN, AGE
Papers on neutrophil gelatinase-associated lipocalin
Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats.
Schupp et al., Muscat, Oman. In Cell Physiol Biochem, Feb 2016
RESULTS: Adenine lowered creatinine clearance and elevated the concentrations of urea, creatinine, plasma neutrophil gelatinase-associated lipocalin and urinary N-Acetyl-beta-D-glucosaminidase activity, and increased the concentrations of the uremic toxin indoxyl sulfate, in addition to some inflammatory cytokines.
Neuregulin-1 attenuates development of nephropathy in a type 1 diabetes mouse model with high cardiovascular risk.
De Keulenaer et al., Antwerp, Belgium. In Am J Physiol Endocrinol Metab, Feb 2016
Nephropathy was characterized by abnormalities including hyperfiltration, albuminuria, increased urinary neutrophil gelatinase-associated lipocalin, upregulation of renal fibrotic markers and glomerulosclerosis.
Differences in GFR and Tissue Oxygenation, and Interactions between Stenotic and Contralateral Kidneys in Unilateral Atherosclerotic Renovascular Disease.
Textor et al., Rochester, United States. In Clin J Am Soc Nephrol, Feb 2016
Tissue oxygenation (using R(2)* as a measure of deoxyhemoglobin) was determined by blood oxygen level-dependent magnetic resonance imaging at 3 T. Renal vein neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), and plasma renin activity were measured.
Plasma neutrophil gelatinase-associated lipocalin as a marker for the prediction of worsening renal function in children hospitalized for acute heart failure.
Khalifa et al., Az Zaqāzīq, Egypt. In Saudi J Kidney Dis Transpl, Jan 2016
Neutrophil gelatinase-associated lipocalin (NGAL) serves as an early marker for acute renal tubular injury.
Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2.
Terzi et al., Paris, France. In Nat Commun, Dec 2015
Mechanistically, we show that albumin induces tubular unfolded protein response via cytosolic calcium rise, which leads to tubular apoptosis by Lipocalin 2 (LCN2) modulation through ATF4.
Biomarkers of drug-induced acute kidney injury in the adult.
Endre et al., Brisbane, Australia. In Expert Opin Drug Metab Toxicol, Nov 2015
Novel biomarkers, accepted for early detection of drug-induced AKI (kidney injury molecule-1, neutrophil gelatinase-associated lipocalin and N-acetyl-β-d-glucosaminidase), may be useful additions in panels of biomarkers.
Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells.
McCubrey et al., Greenville, United States. In Adv Biol Regul, Nov 2015
This review will summarize the novel roles of the androgen receptor (AR), epidermal growth factor receptor (EGFR), the EGFRvIII variant, TP53, long-non-coding RNAs (lncRNAs), microRNAs (miRs), NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, (NGAL), matrix metalloproteinase-9 (MMP-9), the tumor microenvironment and cancer stem cells (CSC) have on the diagnosis, development and treatment of prostate cancer.
Acute Kidney Injury in Patients with Cirrhosis.
Singal et al., Birmingham, United States. In J Clin Transl Hepatol, Oct 2015
In this regard, novel serum and/or urinary biomarkers such as neutrophil gelatinase-associated lipocalin, interleukins-6 and 18, kidney injury molecule-1, fatty acid binding protein, and endothelin-1 are emerging with a potential for accurately differentiating common causes of AKI.
Practical considerations to drug dosing in children with acute kidney injury.
Sharbaf et al., Chicago, United States. In J Clin Pharmacol, Oct 2015
Serum creatinine and urine output along with volume status should be utilized to guide drug dosing when urinary biomarkers including kidney injury molecule 1, interleukin-18 or neutrophil gelatinase-associated lipocalin are not readily available.
STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch.
Tsuda et al., Fukuoka, Japan. In Nat Med, Aug 2015
Moreover, we identified lipocalin-2 (LCN2) as an astrocytic STAT3-dependent upregulated factor that was crucial for chronic itch, and we demonstrated that intrathecal administration of LCN2 to normal mice increased spinal GRP-evoked scratching.
Neutrophil Gelatinase Associated Lipocalin (NGAL) - a biomarker of renal dysfunction in patients with liver cirrhosis: Do we have enough proof?
Rogoveanu et al., Craiova, Romania. In J Med Life, 2014
In the last decade, various biomarkers of kidney injury have been assessed, and Neutrophil Gelatinase-Associated Lipocalin (NGAL) is one of the most promising and most studied novel biomarker.
Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells.
Ko et al., T'ai-chung-shih, Taiwan. In Toxicol Appl Pharmacol, 2012
lipocalin 2 is a new GADD153 target gene that mediates endoplasmic reticulum stress-induced apoptosis in lung cancer cells
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.
Vijay-Kumar et al., Atlanta, United States. In J Immunol, 2012
Lcn2-mediated regulation of labile iron protects the host against sepsis
Evaluation of neutrophil gelatinase-associated lipocalin in normoalbuminuric normotensive type 1 diabetic adolescents.
Böber et al., İzmir, Turkey. In J Pediatr Endocrinol Metab, 2011
Normoalbuminuric and normotensive adolescents with type 1 diabetes have elevated urinary NGAL values, which might indicate kidney injury.
The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study.
Akin et al., Ankara, Turkey. In J Pediatr Endocrinol Metab, 2011
We do not suggest routine investigation of serum lipocalin-2 level in obese subjects for risk stratification of the obesity-related complications.
Neutrophil gelatinase-associated lipocalin in acute kidney injury.
Kafkas et al., Athens, Greece. In Adv Clin Chem, 2011
The role of neutrophil gelatinase-associated lipocalin (NGAL) in pathophysiology and diagnosis of acute kidney injury is presented. [review]
The Ngal reporter mouse detects the response of the kidney to injury in real time.
Barasch et al., New York City, United States. In Nat Med, 2011
We generated an Ngal reporter mouse by inserting a double-fusion reporter gene encoding luciferase-2 and mCherry (Luc2-mC) into the Ngal (Lcn2) locus.
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma.
Jain et al., Boston, United States. In J Clin Oncol, 2010
Changes in plasma placental growth factor, basic fibroblast growth factor, matrix metalloproteinase (MMP) -2, soluble VEGF receptor 1, stromal cell-derived factor-1alpha, and soluble Tek/Tie2 receptor and in urinary MMP-9/neutrophil gelatinase-associated lipocalin activity after cediranib were associated with radiographic response or survival.
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.
Devarajan et al., Cincinnati, United States. In Lancet, 2005
We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass.
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.
Aderem et al., Seattle, United States. In Nature, 2005
secreted lipocalin 2 limits bacterial growth by sequestrating the iron-laden siderophore
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