Neurotrophins and Neuropathic Pain: Role in Pathobiology.
Brisbane, Australia. In Molecules, 2014
nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and neurotrophin 4. Most research on NTs to date has focussed on the effects of NGF and BDNF signalling via their respective cognate high affinity neurotrophic tyrosine kinase viz TrkA and TrkB receptors.
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
New York City, United States. In Trans Am Clin Climatol Assoc, 2014
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three decades have identified mature BDNF as a key regulator of neuronal differentiation, structure, and function; actions mediated by the TrkB receptor.
Neurotrophins: Role in adverse pregnancy outcome.
Pune, India. In Int J Dev Neurosci, 2014
Neurotrophins such as nerve growth factor (NGF), brain derived neurotrophin (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are naturally occurring molecules that regulate development of the placenta and brain.
Neurotrophin regulation of neural circuit development and function.
Berkeley, United States. In Nat Rev Neurosci, 2013
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function.
The inorganic perspectives of neurotrophins and Alzheimer's disease.
Catania, Italy. In J Inorg Biochem, 2012
Studies indicate neurotrophin family comprises nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 , and Zn(2+) and Cu(2+) interactions with them and modulate their activities through conformational changes.
A model for neuronal competition during development.
Baltimore, United States. In Science, 2008
NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected.
Trk receptors: roles in neuronal signal transduction.
San Francisco, United States. In Annu Rev Biochem, 2002
Trk receptors are a family of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).
IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome
Boca Raton, United States. In Unknown Journal, 0001
After TBI, expression of growth factors such as neurotrophin 4/5, nerve growth factor, basic fibroblast growth factor, brain-derived neurotrophic factor (BDNF), and IGF-1 are increased (Conte et al., 2003; Madathil et al., 2010; Royo et al., 2006).