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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neurotrophin 3

neurotrophin-3, NT-3
a neuronal survival protein [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Brain-derived neurotrophic factor, NGF, CAN, trkC, trkA
Papers using neurotrophin-3 antibodies
Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis
Harada Takayuki et al., In Nature Communications, 2006
... Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of ...
Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs
Twiss Jeffery L. et al., In The Journal of Cell Biology, 2004
... NGF (Harlan), BDNF, NT3 (Alomone Labs), MAG-Fc (R&D Systems), and ...
Papers on neurotrophin-3
Olfactory epithelium neural stem cell implantation restores noise-induced hearing loss in rats.
Cheng et al., Shanghai, China. In Neurosci Lett, Feb 2016
After IL-1β stimulation, nerve growth factor (NGF), neurotrophin-3 (NT-3), and NT-4 levels were evaluated in oe-NSCs.
Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats.
Xian et al., Adelaide, Australia. In J Bone Miner Res, Feb 2016
After a drill-hole injury was made in the tibial growth plate and bone, increased injury site mRNA expression was observed for neurotrophins NGF, BDNF, NT-3 and NT-4 and their Trk receptors.
Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury.
Zeng et al., Guangzhou, China. In Biomaterials, Jan 2016
UNASSIGNED: Persistent neurotrophic factor delivery is crucial to create a microenvironment for cell survival and nerve regeneration in spinal cord injury (SCI).
Molecular Mechanisms Responsible for Neuron-Derived Conditioned Medium (NCM)-Mediated Protection of Ischemic Brain.
Hsueh et al., T'ai-chung-shih, Taiwan. In Plos One, Dec 2015
Immunoblocking and chemical blocking strategies were applied in the in vitro ischemic studies to show that NCM supplement could protect microglia, astrocytes and neurons from GOSD-induced cell death, in a growth factor (TGFβ1, NT-3 and GDNF) and p-ERK dependent manner.
Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
Tjernberg et al., Huddinge, Sweden. In Febs J, Sep 2015
Silencing of probable phospholipid-transporting ATPase IIA, brain-derived neurotrophic factor/neurotrophin-3 growth factor receptor precursor and proton myo-inositol cotransporter (SLC2A13) showed a clear reduction of Aβ and these proteins were selected for further studies on Aβ production and Notch cleavage using small interfering RNA-mediated gene silencing, as well as an overexpression approach.
Charcot-Marie-Tooth type 1A disease from patient to laboratory.
Kanwal et al., In J Pak Med Assoc, Feb 2015
Gene therapy for constant neurotrophin-3 (NT- 3) delivery by secretion by muscle cells for the CMT1A is also one of the possible treatments under trial.
Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review.
Kim et al., Inch'ŏn, South Korea. In Biomed Res Int, 2014
Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease.
Neurotrophins and Neuropathic Pain: Role in Pathobiology.
Smith et al., Brisbane, Australia. In Molecules, 2014
nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 and neurotrophin 4. Most research on NTs to date has focussed on the effects of NGF and BDNF signalling via their respective cognate high affinity neurotrophic tyrosine kinase viz TrkA and TrkB receptors.
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions.
Hempstead, New York City, United States. In Trans Am Clin Climatol Assoc, 2014
Brain-derived neurotrophic factor (BDNF) is a member of a family of neurotrophins which include nerve growth factor, neurotrophin 3, and neurotrophin 4. Studies over the last three decades have identified mature BDNF as a key regulator of neuronal differentiation, structure, and function; actions mediated by the TrkB receptor.
Effects of exogenous neurotrophin-3 on myocyte apoptosis and Ca(2+)-ATP enzyme levels following nerve injury in rats.
Zhao et al., Xinxiang, China. In Int J Clin Exp Med, 2014
This study aims to determine the influence of neurotrophin-3 (NT-3) plasmids on neuronal apoptosis and Ca(2+)-ATP enzyme levels in injured muscles.
Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Luo et al., Stanford, United States. In Science, 2014
Removal of the TrkC ligand neurotrophin-3 (NT-3) from cerebellar granule cells, which provide major afferent input to developing Purkinje cell dendrites, rescued the dendrite defects caused by sparse TrkC disruption in Purkinje cells.
Neurotrophin regulation of neural circuit development and function.
Poo et al., Berkeley, United States. In Nat Rev Neurosci, 2013
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function.
Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.
Rader et al., Philadelphia, United States. In J Clin Invest, 2012
model in which increased hepatic sortilin binds intracellular APOB-containing particles in the Golgi apparatus as well as extracellular LDL at the plasma membrane and traffics them to the lysosome for degradation
TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.
Wang et al., Shanghai, China. In J Neurosci, 2012
Transient receptor potential canonical (TRPC)5 acts as a novel and specific mediator for NT-3 to regulate dendrite development through calcium/calmodulin-dependent protein kinase (CaMK)IIalpha.
Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats.
Jiang et al., Wuxi, China. In Mol Med Report, 2012
Muscle NT-3 levels increased by exercise training contribute to the improvement in caudal nerve conduction velocity in diabetic rats.
Phospholipase D1 is an important regulator of bFGF-induced neurotrophin-3 expression and neurite outgrowth in H19-7 cells.
Han et al., Seoul, South Korea. In Mol Neurobiol, 2012
These results suggest that PLD1 is an important regulator of bFGF-induced NT-3 expression and neurite outgrowth.
Sortilin participates in light-dependent photoreceptor degeneration in vivo.
Frade et al., Granada, Spain. In Plos One, 2011
role of sortilin in light-dependent photoreceptor degeneration
Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival.
Ginty et al., Baltimore, United States. In Cell, 2011
The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons.
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.
Jiang et al., Beijing, China. In Nature, 2008
6-A resolution crystal structure of neurotrophin-3 (NT-3) complexed to the ectodomain of glycosylated p75(NTR).
Neurotrophins mediate human embryonic stem cell survival.
Donovan et al., Baltimore, United States. In Nat Biotechnol, 2006
We show that three TRK ligands, brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4, are survival factors for hES cells.
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