Neuropilins and liver.
Antalya, Turkey. In World J Gastroenterol, Jul 2015
Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
Neuropilins: role in signalling, angiogenesis and disease.
London, United Kingdom. In Chem Immunol Allergy, 2013
Genetic analysis of the role of NRPs in mice shows that NRP1 is essential for embryonic neuronal pathfinding and cardiovascular development, mediated via semaphorins and VEGF, respectively, while NRP2 has a more restricted role in neuronal patterning and lymphangiogenesis.
Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS.
Baltimore, United States. In Nature, 2010
Mice with null mutations in genes encoding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (PlexA3, also known as Plxna3), exhibit increased dentate gyrus (DG) granule cell (GC) and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution.
Hearing improvement after bevacizumab in patients with neurofibromatosis type 2.
Boston, United States. In N Engl J Med, 2009
METHODS: We determined the expression pattern of vascular endothelial growth factor (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vestibular schwannomas associated with neurofibromatosis type 2 and from 22 sporadic schwannomas.