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Neuropilin 1

Neuropilin-1, NPI, Procollagen N-Endopeptidase, neuropilin, NRP1, NP-1
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, CAN, neuropilin-2, KDR, V1a
Papers using Neuropilin-1 antibodies
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
Galli Thierry et al., In The Journal of Cell Biology, 2008
... The following antibodies were used: Nrp1 (Western blotting [WB], 1/1,000 [Millipore]; immunofluorescence [IF], 1/500; [R&D Systems]), PlexA1 (WB, 1/1,000; IF, 1/500; Abcam), tubulin (IF, 1/10,000; Developmental ...
A new mathematical model for relative quantification in real-time RT-PCR
Stemple Derek L, In PLoS Biology, 2000
... Goat polyclonal anti-Nrp1 (C-19) and rabbit polyclonal anti-β-tubulin (H-235) were from Santa Cruz Biotechnology.
Covalently conjugated VEGF—fibrin matrices for endothelialization
Iruela-Arispe M. Luisa et al., In The Journal of Cell Biology, 2000
... Neuropilin-1 antibody was purchased from Santa Cruz Biotechnology, Inc ...
Papers on Neuropilin-1
Tumor Penetrating Peptide Modified DNA Tetrahedron for Targeting Drug Delivery.
He et al., In Biochemistry, Feb 2016
We found that the DNA tetrahedron plays the main role in the endocytosis of U87MG cells, whereas the tumor penetrating peptide could also bind with the transmembrane glycoprotein neuropilin-1 and mediate the endocytosis of the p-TDN nanostructure.
Molecular modelling, synthesis and biological evaluation of peptide inhibitors as anti-angiogenic agent targeting Neuropilin-1 for anticancer application.
Wahab et al., George Town, Malaysia. In J Biomol Struct Dyn, Feb 2016
UNASSIGNED: VEGF and its co-receptor neuropilin-1 (NRP-1) are important targets of many pro-angiogenic factors.
Construction and identification of small hairpin RNA plasmids targeting neuropilin-1 gene and their inhibitory effect on human nasopharyngeal carcinoma CNE-2Z cell proliferation in vitro and in vivo.
Sang et al., Zhengzhou, China. In Eur Arch Otorhinolaryngol, Feb 2016
UNASSIGNED: We observed the effects of small hairpin RNA (shRNA) plasmids targeting neuropilin-1 (NRP-1) gene on human nasopharyngeal carcinoma (NPC) CNE-2Z cell growth in vitro and in vivo.
Ablation of neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression.
Tsirka et al., Stony Brook, United States. In Oncotarget, Feb 2016
Neuropilin 1 (Nrp1) is a transmembrane receptor that in mice both amplifies pro-angiogenic signaling in the tumor microenvironment and affects behavior of innate immune cells.
Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer's Disease.
Tárraga et al., Barcelona, Spain. In J Alzheimers Dis, Feb 2016
Measures included: Mini-Mental State Examination (MMSE), Cognitive Subscale of Alzheimer's Disease Assessment Scale (ADAS-Cog), Rapid Disability Rating Scale (RDRS-2), and Neuropsychiatric Inventory Questionnaire (NPI-Q).
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
Yang et al., Los Angeles, United States. In Nature, Nov 2015
We find that CMT2D mutations alter the conformation of GlyRS, enabling GlyRS(CMT2D) to bind the neuropilin 1 (Nrp1) receptor.
Rivastigmine for Alzheimer's disease.
Grimley Evans et al., Oxford, United Kingdom. In Cochrane Database Syst Rev, Oct 2015
Only one study measured the impact on caregivers using the Neuropsychiatric Inventory-Caregiver Distress (NPI-D) scale and this found no difference between the groups (MD 0.10; 95% CI -0.91 to 1.11, n = 529, 1 study).
Neuropilins and liver.
Elpek, Antalya, Turkey. In World J Gastroenterol, Jul 2015
Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
Semaphorin signaling in cardiovascular development.
Singh et al., Singapore, Singapore. In Cell Metab, Mar 2015
Semaphorins were originally identified as neuronal guidance molecules mediating their attractive or repulsive signals by forming complexes with plexin and neuropilin receptors.
Angiogenesis versus arteriogenesis: neuropilin 1 modulation of VEGF signaling.
Simons et al., New Haven, United States. In F1000prime Rep, 2014
Recent reports show that neuropilin 1 (NRP1), a VEGF receptor, can instill VEGF signaling outcomes that specifically regulate either angiogenesis or arteriogenesis.
Latrepirdine for Alzheimer's disease.
Lanctôt et al., Toronto, Canada. In Cochrane Database Syst Rev, 2014
However, there was some high quality evidence showing a very small benefit of latrepirdine on the Neuropsychiatric Inventory (NPI) (MD -1.77, 95% CI -3.09 to -0.45, 3 studies, P = 0.009) at study endpoint (26 or 52 weeks).
Histamine H3 Receptor Antagonists for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Iwata et al., In J Alzheimers Dis, 2014
Secondary outcomes were Neuropsychiatric Inventory (NPI) scores, discontinuation rate, and individual adverse events/side effects.
Vascular endothelial growth factor-B in physiology and disease.
Alitalo et al., Helsinki, Finland. In Physiol Rev, 2014
Both forms of VEGF-B bind to VEGF-receptor 1 (VEGFR-1) and the neuropilin-1 (NRP-1) coreceptor, which are expressed mainly in blood vascular endothelial cells.
Immunological functions of the neuropilins and plexins as receptors for semaphorins.
Kikutani et al., In Nat Rev Immunol, 2013
In this Review, we focus on the roles of neuropilin 1 (NRP1) and plexins in the regulation of the immune system, and we summarize recent advances in our understanding of their pathological implications.
Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1.
Sapieha et al., Montréal, Canada. In Cell Metab, 2013
We provide evidence from both human and animal studies for the critical role of the classical neuronal guidance cue, semaphorin 3A, in instigating pathological vascular permeability in diabetic retinas via its cognate receptor neuropilin-1.
NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system.
Ruhrberg et al., London, United Kingdom. In Dev Biol, 2012
SEMA3A signalling through NRP1 has multiple cell-autonomous roles in sympathetic nervous system development.
Alleviation of neuropathic pain hypersensitivity by inhibiting neuronal pentraxin 1 in the rostral ventromedial medulla.
Shippenberg et al., Baltimore, United States. In J Neurosci, 2012
Rescue of NP1 expression in the rostral ventromedial medulla (RVM) restores behavioral hypersensitivity of knock-out mice, demonstrating a key role of NP1 in the pathogenesis of neuropathic pain.
An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation.
Detmar et al., Zürich, Switzerland. In Circ Res, 2012
Sema3A-Nrp-1 signaling directs the maturation of the lymphatic vascular network likely via regulating the perivascular cell coverage of the vessels thus affecting lymphatic vessel function and lymphatic valve development.
The wiring of Grueneberg ganglion axons is dependent on neuropilin 1.
Rodriguez et al., Genève, Switzerland. In Development, 2012
the axonal wiring of Grueneberg neurons is dependent on neuropilin 1 expression
SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
Dodé et al., Saint-Pierre-des-Corps, France. In Plos Genet, 2012
Study shows that Nrp1sema/sema mutant mice, which are defective for the semaphorin-binding domain of the membrane coreceptor neuropilin-1, have a Kallmann syndrome -like phenotype
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