60 YEARS OF POMC: POMC: an evolutionary perspective.
Spain. In J Mol Endocrinol, Jan 2016
This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodinorphyn (PDYN) and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event.
[In Process Citation].
Budapest, Hungary. In Orv Hetil, Nov 2015
Neuropeptide Y and substance P were thought to play a role in the function of immune cells and in amplification or elimination of the inflammatory processes.
Neuropeptide Y: An Anti-Aging Player?
Coimbra, Portugal. In Trends Neurosci, Nov 2015
Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination.
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Los Angeles, United States. In Nature, 2012
Unlike the 'classical' opioid receptors, δ, κ and μ (δ-OR, κ-OR and μ-OR), which were delineated by pharmacological criteria in the 1970s and 1980s, the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP, also known as ORL-1) was discovered relatively recently by molecular cloning and characterization of an orphan GPCR.