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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cholinergic receptor, nicotinic, alpha 10

neuronal nicotinic acetylcholine receptor
alpha10 subunit of the nicotininc acetylcholine receptor (nAChR); may heterodimerize with alpha9 subunit [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: alpha7, CAN, beta2, CHRNA4, HAD
Papers on neuronal nicotinic acetylcholine receptor
Engineering α4β2 nAChRs with reduced or increased nicotine sensitivity via selective disruption of consensus sites in the M3-M4 cytoplasmic loop of the α4 subunit.
Lasalde-Dominicci et al., San Juan, Puerto Rico. In Neuropharmacology, Dec 2015
The α4β2 neuronal nicotinic acetylcholine receptor (nAChR) plays a crucial role in nicotine addiction.
Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor.
Ueno et al., Hirosaki, Japan. In Neurosci Res, Nov 2015
We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG), in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit (CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function.
Leonard et al., Aurora, United States. In Neuropharmacology, Sep 2015
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery.
Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds.
Stitzel et al., United States. In Neuropharmacology, Sep 2015
Recent human genetic studies have identified genetic variants in multiple nicotinic acetylcholine receptor (nAChR) subunit genes that are associated with risk for nicotine dependence and other smoking-related measures.
A Case Report on Varenicline Induced Delirium in an Alcohol and Nicotine Dependent Patient.
Thyloth et al., Bengaluru, India. In Indian J Psychol Med, Jul 2015
Varenicline acts as a partial agonist of α4β2 neuronal nicotinic acetylcholine receptor and prevents nicotine binding to the same.
Genetic models of focal epilepsies.
Baulac et al., Paris, France. In J Neurosci Methods, Jul 2015
In this article, we provide an update on the mutational spectrum of neuronal nicotinic acetylcholine receptor genes (CHRNA4, CHRNB2, CHRNA2) and KCNT1 causing autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), and of LGI1 in autosomal dominant epilepsy with auditory features (ADEAF).
Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility.
Maestrini et al., Bologna, Italy. In Am J Med Genet A, Apr 2015
CHRNA7, encoding for the alpha7 subunit of the neuronal nicotinic acetylcholine receptor, is considered the likely culprit gene in mediating neurological phenotypes in 15q13.3
Characterization of a T-superfamily conotoxin TxVC from Conus textile that selectively targets neuronal nAChR subtypes.
Dai et al., Beijing, China. In Biochem Biophys Res Commun, 2014
It selectively targeted the neuronal nicotinic acetylcholine receptor (nAChR) subtypes α4β2 and α3β2, with IC50 values of 343.4 and 1047.2nM,
Genetics advances in autosomal dominant focal epilepsies: focus on DEPDC5.
Baulac, Paris, France. In Prog Brain Res, 2013
Molecular genetic advances in inherited focal epilepsies have pinpointed their genetic heterogeneity and the fact that they are mediated by different biological pathways: ion channel subunit genes have been linked to ADNFLE (CHRNA4, CHRNA2, CHRNB2, and KCNT1, encoding, respectively, the α4, α2, and β2 subunits of the neuronal nicotinic acetylcholine receptor, and a potassium channel subunit); neuronal secreted protein (LGI1-encoding epitempin) has been linked to autosomal dominant epilepsy with auditory features; and mTORC1-repressor DEPDC5 (DEP domain-containing protein 5) gene has recently been reported in a broad spectrum of inherited focal epilepsies (ADNFLE, FTLE, FFEVF).
Genetic matters: thirty years of progress using mouse models in nicotinic research.
Marks, Boulder, United States. In Biochem Pharmacol, 2013
A significant inverse correlation between the locomotor and hypothermic effects and the density of nicotine binding sites suggested that differential expression α4β2-neuronal nicotinic acetylcholine receptor (nAChR) mediated some of this genetic variability.
Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.
McIntosh et al., Salt Lake City, United States. In J Neurochem, 2012
A two order of magnitude species difference in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR.
Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor.
Elgoyhen et al., Buenos Aires, Argentina. In Proc Natl Acad Sci U S A, 2012
The properties of rat and chicken recombinant and native alpha9alpha10 receptors, were compared.
Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear.
Morley et al., Los Angeles, United States. In Neuroscience, 2011
mRNA expression of the nicotinic acetylcholine receptor alpha9 subunit precedes expression of the alpha10 subunit in both cochlear and vestibular hair cells.
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Marchini et al., Oxford, United Kingdom. In Nat Genet, 2010
Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits.
Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts.
Grau et al., Gießen, Germany. In Life Sci, 2007
Allografts were characterized by accumulations of alveolar macrophages strongly expressing the alpha9 and the alpha10 receptor subunit.
Coexpression and spatial association of nicotinic acetylcholine receptor subunits alpha7 and alpha10 in rat sympathetic neurons.
Kummer et al., Gießen, Germany. In J Mol Neurosci, 2005
Distribution of this subunit in rat sympathetic ganglia; posslbe interaction wiwth polypeptide 7 subunit.
Autonomic peripheral neuropathy.
Freeman, Boston, United States. In Lancet, 2005
Certain antibodies (eg, anti-Hu and those directed against neuronal nicotinic acetylcholine receptor) are associated with autonomic signs and symptoms.
The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy.
Casari et al., Milano, Italy. In Nat Genet, 2000
Mutations of the gene encoding the neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4 ) have been found in ADNFLE-ENFL1 families, but these mutations account for only a small proportion of ADNFLE cases.
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine.
Changeux et al., Paris, France. In Nature, 1998
Here we investigate the contribution of the high-affinity neuronal nicotinic acetylcholine receptor to the effects of nicotine on the mesolimbic dopamine system in mice lacking the beta2 subunit of this receptor.
Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors.
Arneric et al., United States. In Science, 1998
A potent (inhibition constant = 37 picomolar) neuronal nicotinic acetylcholine receptor (nAChR) ligand called ABT-594 was developed that has antinociceptive properties equal in efficacy to those of morphine across a series of diverse animal models of acute thermal, persistent chemical, and neuropathic pain states.
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