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Enolase 2

neuron-specific enolase, NSE
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: S-100, HAD, CAN, Synaptophysin, AGE
Papers using neuron-specific enolase antibodies
A case of primary small cell carcinoma of the breast
Supplier
Bergkvist Leif et al., In Pathology Research International, 2006
... (Dako, clone 304-1A5, 1 : 1), CD56 (Zymed Laboratories, clone 123C3, 1 : 100), CD99 (Dako, clone 12E7, 1 : 100), NSE (Dako, clone BBS/NC/VIH14, 1 : 500), synaptophysin ...
Small-cell carcinoma of the gastrointestinal tract: a retrospective study of 64 cases
Supplier
Ghorab Zeina et al., In Diagnostic Pathology, 2003
... NSEPolyclonalDako (Carpinteria, CA) ...
Enteric neural crest-derived cells: origin, identification, migration, and differentiation.
Supplier
Borlongan Cesario V., In PLoS ONE, 2000
... NSE-Cre transgenic construct ...
Molybdenum toxicity and hypocuprosis in ruminants: a review
Supplier
Frank A et al., In Acta Veterinaria Scandinavica, 1977
... were guinea-pig anti-insulin (1:1000, Dako, Hamburg, Germany), rabbit anti-glucagon (1:10, Dako, Hamburg, Germany) and mouse anti-NSE (1:20, Dako, Hamburg, Germany) ...
Papers on neuron-specific enolase
Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA.
New
Heart et al., Cayey, Puerto Rico. In Am J Physiol Endocrinol Metab, Feb 2016
TQ and NSE regulated NAD(P)H/NAD(P)(+) ratios via a redox cycling mechanism.
The New Combination Docetaxel, Prednisone and Curcumin in Patients with Castration-Resistant Prostate Cancer: A Pilot Phase II Study.
New
Eymard et al., Clermont-Ferrand, France. In Oncology, Feb 2016
An ancillary study assessed the seric values of chromogranin A (CgA) and neuron-specific enolase (NSE).
Influence of abiraterone acetate on circulating neuromediators in chemotherapy-naïve castration-resistant prostate cancer.
New
Heinrich et al., Mannheim, Germany. In Prostate, Feb 2016
We evaluated how treatment with AA influences circulating neuromediators chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin-releasing peptide (Pro-GRP) in chemotherapy-naïve CRPC patients.
Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review.
Review
New
Jimenez et al., Cleveland, United States. In Seizure, Jan 2016
Other miscellaneous biomarkers (neuron specific enolase, brain derived neurotropic factor, ghrelin, leptin, leukocytosis) showed no conclusive evidence of utility.
Small Cell Carcinoma of the Urinary Bladder: KIT and PDGFRA Gene Mutations.
New
Kozacioğlu et al., İzmir, Turkey. In Rare Tumors, Jan 2016
Immunohistochemically, the tumor cells were positive for cytokeratin, chromo-granin, synaptophysin, neuron-specific enolase, CD56, CD117 and Ki67 (labeling 70%).
Microcystic/Reticular Schwannoma of the Mandible First Case Report and Review of the Literature.
Review
New
Wu et al., Shanghai, China. In Medicine (baltimore), Nov 2015
Tumor cells were also positive for CD34, CD99, and NSE, but negative for CK, EMA, CK5/6, P63, Calponin, CD10, SMA, Desmin, GFAP, NF, Syn, and CgA.
An open air research study of blast-induced traumatic brain injury to goats.
New
Li et al., Chongqing, China. In Chin J Traumatol, Nov 2015
The systemic physiology, electroencephalogram, serum level of S-100beta, and neuron specific enolase (NSE) were determined pre and post the exposure.
Cardiac Arrest and Postanoxic Encephalopathy.
Review
New
Greer, In Continuum (minneap Minn), Oct 2015
Serum biomarkers that were previously felt to be valid, such as elevated neuron-specific enolase, have been drawn into question owing to multiple reports of patient survival with good outcome despite highly elevated levels.
[Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy].
Review
Sandakova et al., In Ter Arkh, 2014
The magnesium-containing substances include many sequestered antigens, such as glial fibrillary acidic protein, S100, and neuron-specific enolase; magnesium may act as a neuroprotector that is able to modulate the regulation of blood-brain barrier permeability.
Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Review
Scatena et al., Roma, Italy. In Adv Exp Med Biol, 2014
Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase.
Effects of hypothermia on NSE and S-100 protein levels in CSF in neonates following hypoxic/ischaemic brain damage.
GeneRIF
Zhou et al., Shanghai, China. In Acta Paediatr, 2012
NSE levels correlated with neurodevelopmental outcome in infants with hypoxic/ischaemic encephalopathy.
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases.
GeneRIF
Choi et al., Anyang, South Korea. In Biochem J, 2012
Increased citrullination of Arg429 in NSE is associated with Creutzfeldt-Jakob disease and Alzheimer's disease.
Effect of neuronal induction on NSE, Tau, and Oct4 promoter methylation in bone marrow mesenchymal stem cells.
GeneRIF
Xing et al., Zhengzhou, China. In In Vitro Cell Dev Biol Anim, 2012
NSE and Tau are abundantly expressed in the brain cells and MSC-derived neurocyte-like cells.
Exploration and mining of the bacterial terpenome.
Review
Impact
Ikeda et al., Providence, United States. In Acc Chem Res, 2012
Of particular importance is the presence of variants of two universally conserved domains, the aspartate-rich DDXX(D/E) motif and the NSE/DTE triad, (N/D)DXX(S/T)XX(K/R)(D/E). Both domains have been implicated in the binding of the essential divalent cation, typically Mg(2+), that is required for cyclization of the universal acyclic terpene precursors, such as farnesyl and geranyl diphosphate.
Differences in initial NSE levels in malignant and benign diseases of the thoracic wall.
GeneRIF
Bubanović et al., Zagreb, Croatia. In Clin Lab, 2011
The high serum levels of NSE in small cell lung cancer differed significantly from all other cancers including non-small cell lung cancer.
The prognostic values of CA125, CA19.9, NSE, AND SCC for stage I NSCLC are limited.
GeneRIF
Chen et al., Beijing, China. In Cancer Biomark, 2010
Data show that the prognostic values of CA125, CA19.9, neuron-speci fi c enolase (NSE), and squamous cell carcinoma antigen (SCC) for stage I non-small-cell lung cancer NSCLC are limited.
Daily oral everolimus activity in patients with metastatic pancreatic neuroendocrine tumors after failure of cytotoxic chemotherapy: a phase II trial.
Impact
Wiedenmann et al., Houston, United States. In J Clin Oncol, 2010
Chromogranin A (CgA) and neuron-specific enolase (NSE) were assessed monthly if elevated at baseline.
Pyothorax-associated lymphoma: a review of 106 cases.
Impact
Aozasa et al., Suita, Japan. In J Clin Oncol, 2002
Laboratory data showed that the serum neuron-specific enolase level was occasionally elevated (3.55 to 168.7 ng/mL; median, 18.65 ng/mL), suggesting a possible diagnosis of small-cell lung cancer.
Circulating neuroblastoma cells detected by reverse transcriptase polymerase chain reaction for tyrosine hydroxylase mRNA are an independent poor prognostic indicator in stage 4 neuroblastoma in children over 1 year.
Impact
Selby et al., Leeds, United Kingdom. In J Clin Oncol, 2001
PATIENTS AND METHODS: The clinical significance of disease detected by RT-PCR in peripheral blood from children at diagnosis was compared with established prognostic markers [ie, age, lactate dehydrogenase (LDH), neuron-specific enolase, ferritin, and MYCN gene amplification] by multivariate analysis.
Neurogenesis in the adult human hippocampus.
Impact
Gage et al., Göteborg, Sweden. In Nat Med, 1998
Using immunofluorescent labeling for BrdU and for one of the neuronal markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans.
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