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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuromedin B

neuromedin B, NMB
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Bombesin, Gastrin, HAD, ACID, gastrin-releasing peptide receptor
Papers on neuromedin B
The Safety of Neuromuscular Blockade Reversal in Patients With Cardiac Transplantation.
Hyder et al., Rochester, United States. In Transplantation, Feb 2016
BACKGROUND: Neuromuscular blockade (NMB) reversal with neostigmine and glycopyrrolate has been reported to cause cardiac arrest in patients with a history of cardiac transplantation.
Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.
Eikermann et al., United States. In Anesthesiology, Dec 2015
METHODS: The dose-response relationship of drugs to reverse vecuronium-, rocuronium-, and cisatracurium-induced neuromuscular block (NMB) was evaluated in vitro (competition binding assays and urine analysis), ex vivo (n = 34; phrenic nerve hemidiaphragm preparation), and in vivo (n = 108; quadriceps femoris muscle of the rat).
Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor antagonists.
Roesler et al., Porto Alegre, Brazil. In Childs Nerv Syst, Dec 2015
METHODS: D283 MB cells were treated with different doses of the HDACi sodium butyrate (NaB), the neuromedin B receptor (NMBR) antagonist BIM-23127, the gastrin releasing peptide receptor (GRPR) antagonist RC-3095, or combinations of NaB with each receptor antagonist.
Reversal of neuromuscular block in companion animals.
Mosing et al., Vienna, Austria. In Vet Anaesth Analg, Sep 2015
OBJECTIVE: To review the evidence regarding the reversal of neuromuscular block (NMB) in companion animals with emphasis on the development and use of newer agents.
Sugammadex: A Comprehensive Review of the Published Human Science, Including Renal Studies.
Jahr et al., Los Angeles, United States. In Am J Ther, Jul 2015
Although neuromuscular block (NMB) allows immobility for airway management and surgical exposure, termination of its effect is limited by and associated with side effects of acetylcholinesterase inhibitors.
EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer.
Vahdat et al., Nashville, United States. In J Clin Oncol, Jun 2015
PURPOSE: Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types.
Bombesin-like peptides and their receptors: recent findings in pharmacology and physiology.
Qin et al., Changsha, China. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
Both gastrin-releasing peptide receptor and neuromedin B receptor activation were shown to induce membrane depolarization and excite neurons in brain.
Gastrointestinal peptides and itch sensation.
Weber, Boston, United States. In Curr Opin Endocrinol Diabetes Obes, Feb 2015
Several neuropeptides including GRP, neuromedin B, and substance P regulate itch signals in a cooperative or inhibitory manner on the spinal level.
Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity.
Puigserver et al., Boston, United States. In Mol Cell Biol, 2014
In contrast, YY1 represses a series of secreted proteins, including fibroblast growth factor 21 (FGF21), bone morphogenetic protein 8b (BMP8b), growth differentiation factor 15 (GDF15), angiopoietin-like 6 (Angptl6), neuromedin B, and nesfatin, linked to energy expenditure.
Mechanism of bombesin-induced tonic contraction of the porcine lower esophageal sphincter.
Huang et al., Kao-hsiung, Taiwan. In Sci Rep, 2014
We used the selective agonists, neuromedin B (NMB), gastrin-releasing peptide (GRP), and [D-Tyr(6),Apa-4Cl(11),Phe(13),Nle(14)]bombesin-(6-14) (DTACPN-BN), as well as receptor antagonists of bombesin receptor subtype 2 (BB2), and 3 (BB3) for ex vivo contraction studies.
Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with advanced melanoma.
Hwu et al., Los Angeles, United States. In J Clin Oncol, 2014
PURPOSE: The antibody-drug conjugate glembatumumab vedotin links a fully human immunoglobulin G2 monoclonal antibody against the melanoma-related glycoprotein NMB (gpNMB) to the potent cytotoxin monomethyl auristatin E. This study evaluated the safety and activity of glembatumumab vedotin in patients with advanced melanoma.
Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer.
Vahdat et al., Nashville, United States. In J Clin Oncol, 2014
PURPOSE: Glycoprotein NMB (gpNMB), a novel transmembrane protein overexpressed in 40% to 60% of breast cancers, promotes metastases in animal models and is a prognostic marker of a poor outcome in patients.
Sugammadex: A revolutionary drug in neuromuscular pharmacology.
Parthasarathy et al., Pondicherry, India. In Anesth Essays Res, 2013
Sugammadex (ORG 25969) is a unique neuromuscular reversal drug; a novel cyclodextrin, the first in a new class of selective relaxant binding agents, which reverse neuromuscular blockade (NMB) with the aminosteroid non-depolarizing muscle relaxants rocuronium and vecuronium.
Glycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells.
Juang et al., Taiwan. In Prostate, 2012
Together these results suggest that GPNMB gene is a p53- and androgen-dysregulated gene and should be regarded as an anti-tumor gene for prostate cancer.
Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice.
Liang et al., Changsha, China. In Biol Reprod, 2012
The data demonstrated that the neuromedin B-neuromedian B receptor interaction in pregnant myometrial primary cells in vitro predominantly influenced uterine activity through regulation of Il6 expression via the Rela/p65 pathway.
The immune inhibitory receptor osteoactivin is upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors.
Grünebach et al., Tübingen, Germany. In Cancer Immunol Immunother, 2012
upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors
Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.
Lau et al., Loma Linda, United States. In Plos One, 2011
Osteoclast-derived osteoactivin is a novel stimulator of osteoclast activity and bone resorption.
Gastrointestinal stromal tumours can express CD10 and epithelial membrane antigen but not oestrogen receptor or HMB45.
Melegh et al., Bristol, United Kingdom. In Histopathology, 2011
Gastrointestinal stromal tumours do not show immunopositivity for ERa or HMB45.
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.
Benya et al., Bethesda, United States. In Pharmacol Rev, 2008
The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB(1)), the gastrin-releasing peptide (GRP) receptor (BB(2)), and the orphan receptor bombesin receptor subtype 3 (BRS-3) (BB(3)).
Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.
Wada et al., Kodaira, Japan. In Nature, 1997
Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor subtype-3 (BRS-3).
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